Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366393712> ?p ?o ?g. }
- W4366393712 endingPage "122970" @default.
- W4366393712 startingPage "122970" @default.
- W4366393712 abstract "The low level of T-lymphocyte infiltration in tumor is a key issue in cancer immunotherapy. Stimulating anti-tumor immune responses and improving the tumor microenvironment are essential for enhancing anti-PD-L1 immunotherapy. Herein, atovaquone (ATO), protoporphyrin IX (PpIX), and stabilizer (ATO/PpIX NPs) were constructed to self-assemble with hydrophobic interaction and passively targeted to tumor for the first time. The studies have indicated that PpIX-mediated photodynamic induction of immunogenic cell death combined with relieving tumor hypoxia by ATO, leading to maturation of dendritic cells, polarization of M2-type tumor-associated macrophages (TAMs) towards M1-type TAMs, infiltration of cytotoxic T lymphocytes, reduction of regulatory T cells, release of pro-inflammatory cytokines, resulting in an effective anti-tumor immune response synergized with anti-PD-L1 against primary tumor and pulmonary metastasis. Taken together, the combined nanoplatform may be a promising strategy to enhance cancer immunotherapy." @default.
- W4366393712 created "2023-04-21" @default.
- W4366393712 creator A5007054845 @default.
- W4366393712 creator A5052441498 @default.
- W4366393712 creator A5063046811 @default.
- W4366393712 creator A5069756468 @default.
- W4366393712 creator A5074855762 @default.
- W4366393712 creator A5087697853 @default.
- W4366393712 date "2023-05-01" @default.
- W4366393712 modified "2023-10-05" @default.
- W4366393712 title "Self-delivery photodynamic-hypoxia alleviating nanomedicine synergizes with anti-PD-L1 for cancer immunotherapy" @default.
- W4366393712 cites W1978094989 @default.
- W4366393712 cites W2013765163 @default.
- W4366393712 cites W2026878412 @default.
- W4366393712 cites W2052874737 @default.
- W4366393712 cites W2073399837 @default.
- W4366393712 cites W2499786133 @default.
- W4366393712 cites W2560185130 @default.
- W4366393712 cites W2596760231 @default.
- W4366393712 cites W2758783177 @default.
- W4366393712 cites W2804669050 @default.
- W4366393712 cites W2805301164 @default.
- W4366393712 cites W2947137287 @default.
- W4366393712 cites W2988254969 @default.
- W4366393712 cites W3024655951 @default.
- W4366393712 cites W3096710313 @default.
- W4366393712 cites W3099307826 @default.
- W4366393712 cites W3102549282 @default.
- W4366393712 cites W3109801031 @default.
- W4366393712 cites W3126377118 @default.
- W4366393712 cites W3126492050 @default.
- W4366393712 cites W3136532314 @default.
- W4366393712 cites W3137667293 @default.
- W4366393712 cites W3148827717 @default.
- W4366393712 cites W3160567474 @default.
- W4366393712 cites W3184487624 @default.
- W4366393712 cites W3193528666 @default.
- W4366393712 cites W3203675877 @default.
- W4366393712 cites W4200376172 @default.
- W4366393712 cites W4207033714 @default.
- W4366393712 cites W4210473220 @default.
- W4366393712 cites W4214823789 @default.
- W4366393712 cites W4221016253 @default.
- W4366393712 cites W4225113325 @default.
- W4366393712 cites W4225264597 @default.
- W4366393712 cites W4225845169 @default.
- W4366393712 cites W4280522212 @default.
- W4366393712 cites W4283700010 @default.
- W4366393712 cites W4294991275 @default.
- W4366393712 cites W4306250770 @default.
- W4366393712 cites W4306901855 @default.
- W4366393712 cites W4308620419 @default.
- W4366393712 cites W4308739634 @default.
- W4366393712 cites W4309743026 @default.
- W4366393712 cites W4310335919 @default.
- W4366393712 cites W4311670295 @default.
- W4366393712 cites W4312018960 @default.
- W4366393712 cites W4312187647 @default.
- W4366393712 cites W4313278998 @default.
- W4366393712 cites W4313478249 @default.
- W4366393712 doi "https://doi.org/10.1016/j.ijpharm.2023.122970" @default.
- W4366393712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37084832" @default.
- W4366393712 hasPublicationYear "2023" @default.
- W4366393712 type Work @default.
- W4366393712 citedByCount "1" @default.
- W4366393712 crossrefType "journal-article" @default.
- W4366393712 hasAuthorship W4366393712A5007054845 @default.
- W4366393712 hasAuthorship W4366393712A5052441498 @default.
- W4366393712 hasAuthorship W4366393712A5063046811 @default.
- W4366393712 hasAuthorship W4366393712A5069756468 @default.
- W4366393712 hasAuthorship W4366393712A5074855762 @default.
- W4366393712 hasAuthorship W4366393712A5087697853 @default.
- W4366393712 hasConcept C121608353 @default.
- W4366393712 hasConcept C126322002 @default.
- W4366393712 hasConcept C154317977 @default.
- W4366393712 hasConcept C178790620 @default.
- W4366393712 hasConcept C185592680 @default.
- W4366393712 hasConcept C202751555 @default.
- W4366393712 hasConcept C203014093 @default.
- W4366393712 hasConcept C2776107976 @default.
- W4366393712 hasConcept C2777658100 @default.
- W4366393712 hasConcept C2777701055 @default.
- W4366393712 hasConcept C2777877232 @default.
- W4366393712 hasConcept C2779013556 @default.
- W4366393712 hasConcept C2779081379 @default.
- W4366393712 hasConcept C2780674031 @default.
- W4366393712 hasConcept C2781323092 @default.
- W4366393712 hasConcept C502942594 @default.
- W4366393712 hasConcept C509974204 @default.
- W4366393712 hasConcept C55493867 @default.
- W4366393712 hasConcept C71924100 @default.
- W4366393712 hasConcept C8891405 @default.
- W4366393712 hasConceptScore W4366393712C121608353 @default.
- W4366393712 hasConceptScore W4366393712C126322002 @default.
- W4366393712 hasConceptScore W4366393712C154317977 @default.
- W4366393712 hasConceptScore W4366393712C178790620 @default.
- W4366393712 hasConceptScore W4366393712C185592680 @default.
- W4366393712 hasConceptScore W4366393712C202751555 @default.