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- W4366405868 abstract "Endosomal escape remains a central issue limiting the high protein expression of mRNA therapeutics. Here, we present second near-infrared (NIR-II) lipid nanoparticles (LNPs) containing pH activatable NIR-II dye conjugated lipid (Cy-lipid) for potentiating mRNA delivery efficiency via a stimulus-responsive photothermal-promoted endosomal escape delivery (SPEED) strategy. In acidic endosomal microenvironment, Cy-lipid is protonated and turns on NIR-II absorption for light-to-heat transduction mediated by 1064 nm laser irradiation. Then, the heat-promoted LNPs morphology change triggers rapid escape of NIR-II LNPs from the endosome, allowing about 3-fold enhancement of enhanced green fluorescent protein (eGFP) encoding mRNA translation capacity compared to the NIR-II light free group. In addition, the bioluminescence intensity induced by delivered luciferase encoding mRNA in the mouse liver region shows positive correlation with incremental radiation dose, indicating the validity of the SPEED strategy." @default.
- W4366405868 created "2023-04-21" @default.
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- W4366405868 date "2023-05-09" @default.
- W4366405868 modified "2023-09-23" @default.
- W4366405868 title "Activatable NIR‐II Photothermal Lipid Nanoparticles for Improved Messenger RNA Delivery" @default.
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- W4366405868 doi "https://doi.org/10.1002/ange.202302676" @default.
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