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- W4366421212 abstract "Inactivated vaccines are one of the most effective strategies for controlling the coronavirus disease 2019 (COVID-19) pandemic. However, the response genes for the protective effect of inactivated vaccines are still unclear. Herein, we analysed the neutralization antibody responses elicited by vaccine serum and carried out transcriptome sequencing of RNAs isolated from the PBMCs of 29 medical staff receiving two doses of the CoronaVac vaccine. The results showed that SARS-CoV-2 neutralization antibody titers varied considerably among individuals, and revealed that many innate immune pathways were activated after vaccination. Furthermore, the blue module revealed that NRAS, YWHAB, SMARCA5, PPP1CC and CDC5L may be correlated with the protective effect of the inactivated vaccine. Additionally, MAPK1, CDC42, PPP2CA, EP300, YWHAZ and NRAS were demonstrated as the hub genes having a significant association with vaccines. These findings provide a basis for understanding the molecular mechanism of the host immune response induced by inactivated vaccines." @default.
- W4366421212 created "2023-04-21" @default.
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- W4366421212 date "2023-04-19" @default.
- W4366421212 modified "2023-09-26" @default.
- W4366421212 title "Analysing transcriptomic signatures and identifying potential genes for the protective effect of inactivated COVID-19 vaccines" @default.
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- W4366421212 doi "https://doi.org/10.7717/peerj.15155" @default.
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