FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366428405> ?p ?o ?g. }

• W4366428405 abstract "1 Abstract Decades of research have investigated the molecular and cellular mechanisms that control the immune response to malaria. Yet, many studies offer conflicting results on the functional impact of innate immunity for controlling parasite replication early in infection. We conduct a meta-analysis to probe for consensus on the effect of innate immunity on parasite replication, examining three different species of rodent malaria parasite. Screening published studies that span four decades of research we collate, curate and statistically analyse infection dynamics in immune deficient or augmented mice to identify and quantify consensus and identify sources of disagreement among studies. Additionally, we estimate whether host factors or experimental methodology shape the impact of immune perturbations on parasite burden. First, we detected meta-analytic mean effect sizes (absolute Cohen’s h) for the difference in parasite burden between treatment and control groups ranging from 0.1498 to 0.2321 across parasite species. This range is considered a small effect size and translates to a modest change in parasitaemia of roughly 6-12% on average at the peak of infection. Second, we reveal that variation across studies using P. chabaudi or P. yoelii is best explained by stochasticity (due to small sample sizes) rather than by host factors or experimental design. Third, we find that for P. berghei the impact of immune perturbation is increased when young or female mice are used and is greatest when effector molecules (as opposed to upstream signalling molecules) are disrupted (up to an 18% difference in peak parasitaemia). Finally, we find little evidence of publication bias suggesting that our results are robust. The small effects sizes we observe, across three parasite species, following experimental perturbations of the innate immune system may be explained by redundancy in a complex biological system or by incomplete (or inappropriate) data reporting for meta-analysis. Alternatively, our findings might indicate a need to re-evaluate the efficiency with which innate immunity controls parasite replication early in infection. Testing these explanations is necessary to translate understanding from model systems to human malaria infections, manage immunopathology, and facilitate realism in mathematical models." @default.
• W4366428405 created "2023-04-21" @default.
• W4366428405 creator A5044631327 @default.
• W4366428405 creator A5063631312 @default.
• W4366428405 creator A5075870916 @default.
• W4366428405 creator A5085627828 @default.
• W4366428405 date "2023-04-18" @default.
• W4366428405 modified "2023-10-14" @default.
• W4366428405 title "The impact of innate immunity on malaria parasite infection dynamics" @default.
• W4366428405 cites W1536352104 @default.
• W4366428405 cites W1536637726 @default.
• W4366428405 cites W1970925929 @default.
• W4366428405 cites W1975721615 @default.
• W4366428405 cites W1985544838 @default.
• W4366428405 cites W1993222911 @default.
• W4366428405 cites W2015684672 @default.
• W4366428405 cites W2026268919 @default.
• W4366428405 cites W2031255008 @default.
• W4366428405 cites W2040820653 @default.
• W4366428405 cites W2053388918 @default.
• W4366428405 cites W2055717705 @default.
• W4366428405 cites W2077857097 @default.
• W4366428405 cites W2083547256 @default.
• W4366428405 cites W2102890176 @default.
• W4366428405 cites W2125262450 @default.
• W4366428405 cites W2125435699 @default.
• W4366428405 cites W2126468223 @default.
• W4366428405 cites W2147234629 @default.
• W4366428405 cites W2151783694 @default.
• W4366428405 cites W2166601188 @default.
• W4366428405 cites W2222838875 @default.
• W4366428405 cites W2478169277 @default.
• W4366428405 cites W2543939402 @default.
• W4366428405 cites W2735720719 @default.
• W4366428405 cites W2807981220 @default.
• W4366428405 cites W2896734093 @default.
• W4366428405 cites W2904536134 @default.
• W4366428405 cites W2955201651 @default.
• W4366428405 cites W3016526277 @default.
• W4366428405 cites W3026538346 @default.
• W4366428405 cites W3087629065 @default.
• W4366428405 cites W3109676281 @default.
• W4366428405 cites W3135270875 @default.
• W4366428405 cites W3139289720 @default.
• W4366428405 cites W3157678008 @default.
• W4366428405 cites W3158015415 @default.
• W4366428405 cites W3185274815 @default.
• W4366428405 cites W4231483465 @default.
• W4366428405 cites W4240484632 @default.
• W4366428405 cites W4295941972 @default.
• W4366428405 doi "https://doi.org/10.1101/2023.04.17.537202" @default.
• W4366428405 hasPublicationYear "2023" @default.
• W4366428405 type Work @default.
• W4366428405 citedByCount "0" @default.
• W4366428405 crossrefType "posted-content" @default.
• W4366428405 hasAuthorship W4366428405A5044631327 @default.
• W4366428405 hasAuthorship W4366428405A5063631312 @default.
• W4366428405 hasAuthorship W4366428405A5075870916 @default.
• W4366428405 hasAuthorship W4366428405A5085627828 @default.
• W4366428405 hasBestOaLocation W43664284051 @default.
• W4366428405 hasConcept C136449434 @default.
• W4366428405 hasConcept C136764020 @default.
• W4366428405 hasConcept C193419808 @default.
• W4366428405 hasConcept C203014093 @default.
• W4366428405 hasConcept C2775867548 @default.
• W4366428405 hasConcept C2776486806 @default.
• W4366428405 hasConcept C2778048844 @default.
• W4366428405 hasConcept C2778371730 @default.
• W4366428405 hasConcept C2779341262 @default.
• W4366428405 hasConcept C2780789526 @default.
• W4366428405 hasConcept C41008148 @default.
• W4366428405 hasConcept C51785407 @default.
• W4366428405 hasConcept C71928629 @default.
• W4366428405 hasConcept C86803240 @default.
• W4366428405 hasConcept C8891405 @default.
• W4366428405 hasConceptScore W4366428405C136449434 @default.
• W4366428405 hasConceptScore W4366428405C136764020 @default.
• W4366428405 hasConceptScore W4366428405C193419808 @default.
• W4366428405 hasConceptScore W4366428405C203014093 @default.
• W4366428405 hasConceptScore W4366428405C2775867548 @default.
• W4366428405 hasConceptScore W4366428405C2776486806 @default.
• W4366428405 hasConceptScore W4366428405C2778048844 @default.
• W4366428405 hasConceptScore W4366428405C2778371730 @default.
• W4366428405 hasConceptScore W4366428405C2779341262 @default.
• W4366428405 hasConceptScore W4366428405C2780789526 @default.
• W4366428405 hasConceptScore W4366428405C41008148 @default.
• W4366428405 hasConceptScore W4366428405C51785407 @default.
• W4366428405 hasConceptScore W4366428405C71928629 @default.
• W4366428405 hasConceptScore W4366428405C86803240 @default.
• W4366428405 hasConceptScore W4366428405C8891405 @default.
• W4366428405 hasLocation W43664284051 @default.
• W4366428405 hasOpenAccess W4366428405 @default.
• W4366428405 hasPrimaryLocation W43664284051 @default.
• W4366428405 hasRelatedWork W1574628415 @default.
• W4366428405 hasRelatedWork W2037826520 @default.
• W4366428405 hasRelatedWork W2103515427 @default.
• W4366428405 hasRelatedWork W2141330728 @default.
• W4366428405 hasRelatedWork W2161366189 @default.
• W4366428405 hasRelatedWork W2188294308 @default.
• W4366428405 hasRelatedWork W2223869382 @default.

• next