Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366431468> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W4366431468 abstract "The present study aimed to separate the three-drug combination and degradant products by applying stress studies in bulk and pharmaceutical using RP-HPLC green analytical chemistry principles to make the separation better and more effective without compromising the standard limits. The three drugs have separated using the Mobile Phase Mixture of 10 volumes of buffer (0.1% triethanolamine in water) and 90 volumes of ethanol on the stationary phase Inertsil ODS 3 (250 mm x 4.6 mm), 5 µm column, at a wavelength of 256 nm. The method has been performed on a linear concentration range of 12–28 µg/mL for ATR, EZB, and 192- 448 µg/mL for FNF. The forced degradation studies showed that the ATR had > 5% degradation in acid, peroxide and thermal degradation, as EZB tends to degrade more than 15% at alkali hydrolysis. Moreover, the methodology has been validated according to ICH Q2 R1 guidelines, assessed using green evaluation tools like GAPI, AES, and AGREE, and found eco-friendly according to the output of the greenness outcomes. The developed method employed for determining three drugs has shown within limits according to the guidelines, easily adaptable by the pharmaceutical industries for their regular quality control analysis of the combinations." @default.
- W4366431468 created "2023-04-21" @default.
- W4366431468 creator A5028682139 @default.
- W4366431468 creator A5043117322 @default.
- W4366431468 creator A5046262268 @default.
- W4366431468 creator A5072579813 @default.
- W4366431468 date "2023-01-02" @default.
- W4366431468 modified "2023-10-18" @default.
- W4366431468 title "Method development and validation of Atorvastatin, Ezetimibe and Fenofibrate using RP-HPLC along with their forced degradation studies and greenness profiling" @default.
- W4366431468 cites W140555428 @default.
- W4366431468 cites W1503376607 @default.
- W4366431468 cites W1980761905 @default.
- W4366431468 cites W1987760310 @default.
- W4366431468 cites W2002033062 @default.
- W4366431468 cites W2103134123 @default.
- W4366431468 cites W2112161950 @default.
- W4366431468 cites W2144593072 @default.
- W4366431468 cites W2167045683 @default.
- W4366431468 cites W2502161807 @default.
- W4366431468 cites W2603809447 @default.
- W4366431468 cites W2756181452 @default.
- W4366431468 cites W2781931056 @default.
- W4366431468 cites W3022529523 @default.
- W4366431468 cites W3035028232 @default.
- W4366431468 cites W3080614931 @default.
- W4366431468 cites W3111394176 @default.
- W4366431468 cites W3186027416 @default.
- W4366431468 cites W3196814808 @default.
- W4366431468 cites W4205853098 @default.
- W4366431468 cites W4210511145 @default.
- W4366431468 cites W4281656395 @default.
- W4366431468 cites W4288760217 @default.
- W4366431468 cites W4309565726 @default.
- W4366431468 doi "https://doi.org/10.1080/17518253.2023.2198651" @default.
- W4366431468 hasPublicationYear "2023" @default.
- W4366431468 type Work @default.
- W4366431468 citedByCount "0" @default.
- W4366431468 crossrefType "journal-article" @default.
- W4366431468 hasAuthorship W4366431468A5028682139 @default.
- W4366431468 hasAuthorship W4366431468A5043117322 @default.
- W4366431468 hasAuthorship W4366431468A5046262268 @default.
- W4366431468 hasAuthorship W4366431468A5072579813 @default.
- W4366431468 hasBestOaLocation W43664314681 @default.
- W4366431468 hasConcept C113196181 @default.
- W4366431468 hasConcept C119128265 @default.
- W4366431468 hasConcept C134018914 @default.
- W4366431468 hasConcept C179998833 @default.
- W4366431468 hasConcept C185592680 @default.
- W4366431468 hasConcept C2775897365 @default.
- W4366431468 hasConcept C2777482532 @default.
- W4366431468 hasConcept C2777682752 @default.
- W4366431468 hasConcept C2779679103 @default.
- W4366431468 hasConcept C41008148 @default.
- W4366431468 hasConcept C43617362 @default.
- W4366431468 hasConcept C45188465 @default.
- W4366431468 hasConcept C71924100 @default.
- W4366431468 hasConcept C76155785 @default.
- W4366431468 hasConceptScore W4366431468C113196181 @default.
- W4366431468 hasConceptScore W4366431468C119128265 @default.
- W4366431468 hasConceptScore W4366431468C134018914 @default.
- W4366431468 hasConceptScore W4366431468C179998833 @default.
- W4366431468 hasConceptScore W4366431468C185592680 @default.
- W4366431468 hasConceptScore W4366431468C2775897365 @default.
- W4366431468 hasConceptScore W4366431468C2777482532 @default.
- W4366431468 hasConceptScore W4366431468C2777682752 @default.
- W4366431468 hasConceptScore W4366431468C2779679103 @default.
- W4366431468 hasConceptScore W4366431468C41008148 @default.
- W4366431468 hasConceptScore W4366431468C43617362 @default.
- W4366431468 hasConceptScore W4366431468C45188465 @default.
- W4366431468 hasConceptScore W4366431468C71924100 @default.
- W4366431468 hasConceptScore W4366431468C76155785 @default.
- W4366431468 hasIssue "1" @default.
- W4366431468 hasLocation W43664314681 @default.
- W4366431468 hasLocation W43664314682 @default.
- W4366431468 hasOpenAccess W4366431468 @default.
- W4366431468 hasPrimaryLocation W43664314681 @default.
- W4366431468 hasRelatedWork W1506783248 @default.
- W4366431468 hasRelatedWork W2001281989 @default.
- W4366431468 hasRelatedWork W2018522840 @default.
- W4366431468 hasRelatedWork W2599388867 @default.
- W4366431468 hasRelatedWork W3040012780 @default.
- W4366431468 hasRelatedWork W4312089461 @default.
- W4366431468 hasRelatedWork W4322007804 @default.
- W4366431468 hasRelatedWork W4385713070 @default.
- W4366431468 hasRelatedWork W2189305301 @default.
- W4366431468 hasRelatedWork W2189507414 @default.
- W4366431468 hasVolume "16" @default.
- W4366431468 isParatext "false" @default.
- W4366431468 isRetracted "false" @default.
- W4366431468 workType "article" @default.