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- W4366432319 abstract "Sleep and the immune system have a bidirectional relationship, as sleep can strengthen the immune system to achieve balanced and effective immune function, while immune system activation may affect sleep. One of the most relevant topics in this interplay is the effects of sleep disturbances on the immune response to vaccination. The effect of sleep disturbances (including sleep deprivation, sleep restriction, insomnia, and shift work) on the vaccine response has been tested for several diseases, including flu, hepatitis A/B, and meningitis, and in most cases, it leads to a reduced post-vaccination antibody titer. Given these results and considering the COVID-19 pandemic, it has been wondered if sleep disturbances could reduce antibody titers or otherwise reduce the vaccinal response against SARS-CoV-2. The results available so far demonstrate that obstructive sleep apnea among older adults does not lead to reduced antibody titers after vaccination against COVID-19. Regarding circadian rhythmicity, mixed findings were observed when considering the time of the day of COVID-19 vaccination. No studies have been performed regarding sleep deprivation, sleep restriction, or insomnia. In summary, substantial evidence demonstrates that sleep plays an important role in immune system homeostasis and its effects on infection control and vaccine effectiveness. Although the theoretical background suggested sleep disturbances might reduce immune response after vaccination against COVID-19, the current results do not allow concluding it. The effects of sleep on the outcome of COVID-19 and SARS-CoV2 immune responses are still to be better explored, especially concerning conditions that are more classically related to reduced vaccination response (including sleep deprivation and insomnia)." @default.
- W4366432319 created "2023-04-21" @default.
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- W4366432319 date "2023-01-01" @default.
- W4366432319 modified "2023-09-30" @default.
- W4366432319 title "Sleep Disturbances and COVID-19 Vaccines" @default.
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- W4366432319 doi "https://doi.org/10.1007/978-981-99-0240-8_9" @default.
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