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- W4366432909 abstract "To maximize clinical benefit, clinicians routinely tailor treatment to the individual characteristics of each patient, where individualized treatment rules are needed and are of significant research interest to statisticians. In the covariate-adjusted randomization clinical trial with many covariates, we model the treatment effect with an unspecified function of a single index of the covariates and leave the baseline response completely arbitrary. We devise a class of estimators to consistently estimate the treatment effect function and its associated index while bypassing the estimation of the baseline response, which is subject to the curse of dimensionality. We further develop inference tools to identify predictive covariates and isolate effective treatment region. The usefulness of the methods is demonstrated in both simulations and a clinical data example." @default.
- W4366432909 created "2023-04-21" @default.
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- W4366432909 date "2023-01-01" @default.
- W4366432909 modified "2023-09-27" @default.
- W4366432909 title "Flexible inference of optimal individualized treatment strategy in covariate adjusted randomization with multiple covariates" @default.
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- W4366432909 doi "https://doi.org/10.1214/23-ejs2127" @default.
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