Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366444483> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W4366444483 endingPage "357???362" @default.
- W4366444483 startingPage "357???362" @default.
- W4366444483 abstract "We demonstrated previously that several parameters of a morphine discrimination were significantly different in female versus male rats, using a fixed ratio (FR)-l0 schedule of food reinforcement however, this schedule produced a significant bias in reinforcement frequency between saline and morphine sessions in males but not in females. To determine whether this schedule—drug—sex interaction caused the sex difference in discriminability of morphine, female and male rats were trained to discriminate 3.0mg/kg morphine from saline using a variable interval (VI) 15-s/VI 15-s (Phase 1), a VI 7.5-s/Vl 15-s (Phase II), and a VI 15-s/Vl 15-s (Phase 111) schedule of food reinforcement on morphine/saline levers, respectively. After a minimum of 40 training sessions in each phase, mean reinforcement rates in morphine sessions were highest and the ED50 values for morphine discrimination were lowest, in Phase II. Thus, as predicted, the morphine dose-effect curves shifted to the left from Phase 1 to Phase II, and back to the right from Phase n to m, presumably due to the bias in reinforcement rate between saline and morphine sessions that was induced by manipulating the VI schedule on the morphine lever. However, there were no sex differences in the morphine versus saline reinforcement rate or in discrimination ED50 in any phase, suggesting that the sex difference observed in our initial study was probably due to the bias in reinforcement frequency (towards the saline condition) that occurred only in males under the FR-10 schedule. This study demonstrates the importance of considering group differences in schedule—drug interactions when comparing discriminative stimulus properties of drugs between groups. Behav Pharmacol 1998; 9:357–362 1998 Lippincott-Raven Publishers." @default.
- W4366444483 created "2023-04-22" @default.
- W4366444483 creator A5066884110 @default.
- W4366444483 creator A5084094238 @default.
- W4366444483 creator A5088668695 @default.
- W4366444483 date "1998-07-01" @default.
- W4366444483 modified "2023-10-14" @default.
- W4366444483 title "Reinforcement frequency, but not gender, determines sensitivity,to discriminative discriminative stimulus effects of. morphine" @default.
- W4366444483 doi "https://doi.org/10.1097/00008877-199807000-00007" @default.
- W4366444483 hasPublicationYear "1998" @default.
- W4366444483 type Work @default.
- W4366444483 citedByCount "9" @default.
- W4366444483 countsByYear W43664444832022 @default.
- W4366444483 crossrefType "journal-article" @default.
- W4366444483 hasAuthorship W4366444483A5066884110 @default.
- W4366444483 hasAuthorship W4366444483A5084094238 @default.
- W4366444483 hasAuthorship W4366444483A5088668695 @default.
- W4366444483 hasConcept C126322002 @default.
- W4366444483 hasConcept C15744967 @default.
- W4366444483 hasConcept C2777389121 @default.
- W4366444483 hasConcept C2777397205 @default.
- W4366444483 hasConcept C2779547902 @default.
- W4366444483 hasConcept C2779918689 @default.
- W4366444483 hasConcept C42219234 @default.
- W4366444483 hasConcept C542102704 @default.
- W4366444483 hasConcept C548259974 @default.
- W4366444483 hasConcept C57022672 @default.
- W4366444483 hasConcept C67203356 @default.
- W4366444483 hasConcept C71924100 @default.
- W4366444483 hasConcept C77805123 @default.
- W4366444483 hasConceptScore W4366444483C126322002 @default.
- W4366444483 hasConceptScore W4366444483C15744967 @default.
- W4366444483 hasConceptScore W4366444483C2777389121 @default.
- W4366444483 hasConceptScore W4366444483C2777397205 @default.
- W4366444483 hasConceptScore W4366444483C2779547902 @default.
- W4366444483 hasConceptScore W4366444483C2779918689 @default.
- W4366444483 hasConceptScore W4366444483C42219234 @default.
- W4366444483 hasConceptScore W4366444483C542102704 @default.
- W4366444483 hasConceptScore W4366444483C548259974 @default.
- W4366444483 hasConceptScore W4366444483C57022672 @default.
- W4366444483 hasConceptScore W4366444483C67203356 @default.
- W4366444483 hasConceptScore W4366444483C71924100 @default.
- W4366444483 hasConceptScore W4366444483C77805123 @default.
- W4366444483 hasIssue "4" @default.
- W4366444483 hasLocation W43664444831 @default.
- W4366444483 hasOpenAccess W4366444483 @default.
- W4366444483 hasPrimaryLocation W43664444831 @default.
- W4366444483 hasRelatedWork W1973856495 @default.
- W4366444483 hasRelatedWork W1974630739 @default.
- W4366444483 hasRelatedWork W2061915250 @default.
- W4366444483 hasRelatedWork W2062551001 @default.
- W4366444483 hasRelatedWork W2065058827 @default.
- W4366444483 hasRelatedWork W2078570269 @default.
- W4366444483 hasRelatedWork W2082894743 @default.
- W4366444483 hasRelatedWork W2121192877 @default.
- W4366444483 hasRelatedWork W2167113305 @default.
- W4366444483 hasRelatedWork W2471271714 @default.
- W4366444483 hasVolume "9" @default.
- W4366444483 isParatext "false" @default.
- W4366444483 isRetracted "false" @default.
- W4366444483 workType "article" @default.