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- W4366448475 abstract "Abstract Purpose This study aimed to evaluate the clinical significance of surgical resection for liver recurrence in patients with curatively resected pancreatic ductal adenocarcinoma. Methods The medical records of patients who had a liver recurrence after undergoing curative pancreatectomy for pancreatic ductal adenocarcinoma were retrospectively reviewed. Clinicopathological and prognostic factors were analyzed, as was the clinical impact of surgical resection for liver recurrence. Results Overall, 502 patients underwent curative pancreatic ductal adenocarcinoma resection. Of the 311 patients with recurrence after curative pancreatectomy, 71 (23%) had an initial recurrence in the liver, with 35 having solitary recurrence (11%). Patients with solitary, two or three, or > four recurrences had median overall survival times of 28.5, 18.0, and 12.2 months, respectively (p < 0.001). Surgical indications for liver recurrence in our institution included solitary tumor, good disease control under chemotherapy after recurrence for > 6 months, and sufficient remnant liver function. Ten patients who met our institutional policy inclusion criteria underwent liver resection. In 35 patients with initially solitary liver recurrence, those who underwent liver resection outlived those who did not (57.6 months vs. 20.1 months, p < 0.001). In multivariate analysis of overall survival, solitary liver recurrence, and liver resection were independent favorable prognostic factors in patients with initial liver recurrence. Conclusion In selected patients with solitary liver recurrence after curatively resected pancreatic ductal adenocarcinoma, liver resection may be a treatment option." @default.
- W4366448475 created "2023-04-22" @default.
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- W4366448475 date "2023-04-19" @default.
- W4366448475 modified "2023-10-12" @default.
- W4366448475 title "Surgical resection for liver recurrence after curative resection of pancreatic ductal adenocarcinoma" @default.
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- W4366448475 doi "https://doi.org/10.21203/rs.3.rs-2825653/v1" @default.
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