FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366451339> ?p ?o ?g. }

• W4366451339 abstract "Abstract Various recent studies have shown a link between the gut microbiome and bone mineral density (BMD). Whether the link represents a causative relationship, however, remains unclear. This study aims to thoroughly investigate the causal effects of the gut microbiome on BMD and pinpoint which particular gut microbe taxa have causal effects on BMDs at different specific skeletal sites. Based on summary statistics from genome-wide association studies (GWAS), a two-sample Mendelian randomization (MR) study was carried out to examine the effects of the gut microbiome at five taxonomic ranks (phylum, class, order, family, and genus) on BMDs at five skeletal sites (total body BMD [TB-BMD], femoral neck BMD [FN-BMD], forearm BMD [FA-BMD], heel BMD [H-BMD], lumbar spine BMD [LS-BMD]). After Bonferroni correction, a negative causal effect of the genus Eisenbergiella was shown exclusively on H-BMD (inverse variance weighted (IVW): β = -0.037, 95% confidence interval (CI) = -0.055, -0.018, P = 0.0001). On the contrary, the genus Oscillibacter had a positive causal effect exclusively on H-BMD (IVW: β = 0.029, 95% CI = 0.013, 0.044, P = 0.0003). At other skeletal sites, only nominal causal effects were observed. The reliability of these findings was strengthened by our following several sensitivity studies. A reverse MR analysis was conducted, which showed no reverse causation between H-BMD and the beforementioned two genera, Eisenbergiella and Oscillibacter . These findings show insights into the pathophysiology of low BMD and the association between the gut microbiome and bone health." @default.
• W4366451339 created "2023-04-22" @default.
• W4366451339 creator A5008413456 @default.
• W4366451339 creator A5012158214 @default.
• W4366451339 creator A5021504328 @default.
• W4366451339 creator A5025610162 @default.
• W4366451339 creator A5033984813 @default.
• W4366451339 creator A5062207182 @default.
• W4366451339 creator A5063613320 @default.
• W4366451339 creator A5078447208 @default.
• W4366451339 creator A5090874241 @default.
• W4366451339 date "2023-04-19" @default.
• W4366451339 modified "2023-09-27" @default.
• W4366451339 title "Causal relationship between Human Gut Microbiome and Bone Mineral Density: A Mendelian Randomization Study" @default.
• W4366451339 cites W1504356861 @default.
• W4366451339 cites W1546272694 @default.
• W4366451339 cites W1905058580 @default.
• W4366451339 cites W1970501743 @default.
• W4366451339 cites W1971571303 @default.
• W4366451339 cites W1980471449 @default.
• W4366451339 cites W2010793737 @default.
• W4366451339 cites W2012490955 @default.
• W4366451339 cites W2031403388 @default.
• W4366451339 cites W2036125852 @default.
• W4366451339 cites W2060915147 @default.
• W4366451339 cites W2071841602 @default.
• W4366451339 cites W2077305316 @default.
• W4366451339 cites W2093053972 @default.
• W4366451339 cites W2106036991 @default.
• W4366451339 cites W2110768118 @default.
• W4366451339 cites W2113552312 @default.
• W4366451339 cites W2113699335 @default.
• W4366451339 cites W2114344041 @default.
• W4366451339 cites W2125826054 @default.
• W4366451339 cites W2128736149 @default.
• W4366451339 cites W2134019217 @default.
• W4366451339 cites W2136598250 @default.
• W4366451339 cites W2138330280 @default.
• W4366451339 cites W2140346815 @default.
• W4366451339 cites W2144568881 @default.
• W4366451339 cites W2147024879 @default.
• W4366451339 cites W2151209074 @default.
• W4366451339 cites W2152799367 @default.
• W4366451339 cites W2155132414 @default.
• W4366451339 cites W2161555525 @default.
• W4366451339 cites W2169208062 @default.
• W4366451339 cites W2171709369 @default.
• W4366451339 cites W2187181884 @default.
• W4366451339 cites W2293993925 @default.
• W4366451339 cites W2302688695 @default.
• W4366451339 cites W2324862792 @default.
• W4366451339 cites W2325761966 @default.
• W4366451339 cites W2398690791 @default.
• W4366451339 cites W2520048741 @default.
• W4366451339 cites W2624855391 @default.
• W4366451339 cites W2736782317 @default.
• W4366451339 cites W2746834188 @default.
• W4366451339 cites W2751430583 @default.
• W4366451339 cites W2768741494 @default.
• W4366451339 cites W2778082937 @default.
• W4366451339 cites W2781976437 @default.
• W4366451339 cites W2803072880 @default.
• W4366451339 cites W2805983714 @default.
• W4366451339 cites W2808457437 @default.
• W4366451339 cites W2818417770 @default.
• W4366451339 cites W2901898635 @default.
• W4366451339 cites W2904039649 @default.
• W4366451339 cites W2912162696 @default.
• W4366451339 cites W2916785934 @default.
• W4366451339 cites W2931072712 @default.
• W4366451339 cites W2955177623 @default.
• W4366451339 cites W2966155190 @default.
• W4366451339 cites W2970393109 @default.
• W4366451339 cites W3002683408 @default.
• W4366451339 cites W3003943547 @default.
• W4366451339 cites W3021016447 @default.
• W4366451339 cites W3037859398 @default.
• W4366451339 cites W3083241614 @default.
• W4366451339 cites W3087844061 @default.
• W4366451339 cites W3089079312 @default.
• W4366451339 cites W3121407008 @default.
• W4366451339 cites W3159532480 @default.
• W4366451339 cites W3179608705 @default.
• W4366451339 cites W3194701550 @default.
• W4366451339 cites W3198057487 @default.
• W4366451339 cites W3210570897 @default.
• W4366451339 cites W3211588961 @default.
• W4366451339 cites W4200023607 @default.
• W4366451339 cites W4206806868 @default.
• W4366451339 cites W4206950286 @default.
• W4366451339 cites W4210670764 @default.
• W4366451339 cites W4211141844 @default.
• W4366451339 cites W4211229201 @default.
• W4366451339 cites W4232889119 @default.
• W4366451339 doi "https://doi.org/10.21203/rs.3.rs-2822776/v1" @default.
• W4366451339 hasPublicationYear "2023" @default.
• W4366451339 type Work @default.
• W4366451339 citedByCount "0" @default.
• W4366451339 crossrefType "posted-content" @default.
• W4366451339 hasAuthorship W4366451339A5008413456 @default.

• next