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- W4366455246 abstract "Susceptibility to N-methyl-N-nitrosourea (MNU)–induced lymphomas is a multigenic trait. We previously mapped a resistance locus (Tlag1) to mouse chromosome 7 in genetic crosses of sensitive AKR with resistant C57L mice. Analysis of the MNU sensitivity of AKXL recombinant inbred strains that are homozygous for the AKR allele of Tlag1 suggested that at least two additional tumor susceptibility loci segregate in these crosses. A second susceptibility locus (Tlag2) now has been mapped to chromosome 4. Only those mice that inherited the susceptibility alleles at both Tlag1 and Tlag2 were sensitive to MNU induction of thymic lymphomas, suggesting that these two loci interact. Chromosome 4 has been associated with susceptibility to hematopoietic tumor development in several mouse models, suggesting that one or more genes mapping to this chromosome are important in lymphomagenesis in general. © 2002 Wiley-Liss, Inc." @default.
- W4366455246 created "2023-04-22" @default.
- W4366455246 creator A5013819753 @default.
- W4366455246 creator A5081959107 @default.
- W4366455246 date "2002-01-25" @default.
- W4366455246 modified "2023-10-06" @default.
- W4366455246 title "Tlag2, anN-methyl-N-nitrosourea susceptibility locus, maps to mouse chromosome 4" @default.
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- W4366455246 doi "https://doi.org/10.1002/mc.10026" @default.
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