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• W4366456065 endingPage "668" @default.
• W4366456065 startingPage "668" @default.
• W4366456065 abstract "Among the phospholipase A2 (PLA2) family, the secreted PLA2 (sPLA2) family in mammals contains 11 members that exhibit unique tissue or cellular distributions and enzymatic properties. Current studies using knockout and/or transgenic mice for a nearly full set of sPLA2s, in combination with comprehensive lipidomics, have revealed the diverse pathophysiological roles of sPLA2s in various biological events. Individual sPLA2s exert specific functions within tissue microenvironments, likely through the hydrolysis of extracellular phospholipids. Lipids are an essential biological component for skin homeostasis, and disturbance of lipid metabolism by deletion or overexpression of lipid-metabolizing enzymes or lipid-sensing receptors often leads to skin abnormalities that are easily visible on the outside. Over the past decades, our studies using knockout and transgenic mice for various sPLA2s have uncovered several new aspects of these enzymes as modulators of skin homeostasis and disease. This article summarizes the roles of several sPLA2s in skin pathophysiology, providing additional insight into the research fields of sPLA2s, lipids, and skin biology." @default.
• W4366456065 created "2023-04-22" @default.
• W4366456065 creator A5062577479 @default.
• W4366456065 creator A5075092495 @default.
• W4366456065 creator A5083519599 @default.
• W4366456065 creator A5078312730 @default.
• W4366456065 date "2023-04-12" @default.
• W4366456065 modified "2023-10-14" @default.
• W4366456065 title "The Roles of sPLA2s in Skin Homeostasis and Disease" @default.
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