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• W4366463211 abstract "Increasing cGMP is a unique therapeutic principle, and drugs inhibiting cGMP-degrading enzymes or stimulating cGMP production are approved for the treatment of various diseases such as erectile dysfunction, coronary artery disease, pulmonary hypertension, chronic heart failure, irritable bowel syndrome, or achondroplasia. In addition, cGMP-increasing therapies are preclinically profiled or in clinical development for quite a broad set of additional indications, e.g., neurodegenerative diseases or different forms of dementias, bone formation disorders, underlining the pivotal role of cGMP signaling pathways. The fundamental understanding of the signaling mediated by nitric oxide-sensitive (soluble) guanylyl cyclase and membrane-associated receptor (particulate) guanylyl cyclase at the molecular and cellular levels, as well as in vivo, especially in disease models, is a key prerequisite to fully exploit treatment opportunities and potential risks that could be associated with an excessive increase in cGMP. Furthermore, human genetic data and the clinical effects of cGMP-increasing drugs allow back-translation into basic research to further learn about signaling and treatment opportunities. The biannual international cGMP conference, launched nearly 20 years ago, brings all these aspects together as an established and important forum for all topics from basic science to clinical research and pivotal clinical trials. This review summarizes the contributions to the 10th cGMP Conference on cGMP Generators, Effectors and Therapeutic Implications, which was held in Augsburg in 2022 but will also provide an overview of recent key achievements and activities in the field of cGMP research." @default.
• W4366463211 created "2023-04-22" @default.
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• W4366463211 creator A5085170891 @default.
• W4366463211 date "2023-04-20" @default.
• W4366463211 modified "2023-10-17" @default.
• W4366463211 title "The 10th International Conference on cGMP 2022: recent trends in cGMP research and development—meeting report" @default.
• W4366463211 cites W1945686959 @default.
• W4366463211 cites W1982627444 @default.
• W4366463211 cites W1984154404 @default.
• W4366463211 cites W1986025894 @default.
• W4366463211 cites W2031055455 @default.
• W4366463211 cites W2043571529 @default.
• W4366463211 cites W2083306941 @default.
• W4366463211 cites W2092312515 @default.
• W4366463211 cites W2097688301 @default.
• W4366463211 cites W2113835063 @default.
• W4366463211 cites W2122386753 @default.
• W4366463211 cites W2136862211 @default.
• W4366463211 cites W2153739004 @default.
• W4366463211 cites W2163559759 @default.
• W4366463211 cites W2181851876 @default.
• W4366463211 cites W2229701246 @default.
• W4366463211 cites W2277675332 @default.
• W4366463211 cites W2319350696 @default.
• W4366463211 cites W2499659154 @default.
• W4366463211 cites W2537735487 @default.
• W4366463211 cites W2569369624 @default.
• W4366463211 cites W2603535098 @default.
• W4366463211 cites W2617300783 @default.
• W4366463211 cites W2761635900 @default.
• W4366463211 cites W2761697926 @default.
• W4366463211 cites W2790455527 @default.
• W4366463211 cites W2793046954 @default.
• W4366463211 cites W2795071637 @default.
• W4366463211 cites W2795136061 @default.
• W4366463211 cites W2795665621 @default.
• W4366463211 cites W2797093446 @default.
• W4366463211 cites W2885993177 @default.
• W4366463211 cites W2900305755 @default.
• W4366463211 cites W2900596261 @default.
• W4366463211 cites W2944422344 @default.
• W4366463211 cites W2946323141 @default.
• W4366463211 cites W2951725244 @default.
• W4366463211 cites W2969596460 @default.
• W4366463211 cites W2972797625 @default.
• W4366463211 cites W2977832678 @default.
• W4366463211 cites W2987185485 @default.
• W4366463211 cites W2990278592 @default.
• W4366463211 cites W2999561702 @default.
• W4366463211 cites W3009554338 @default.
• W4366463211 cites W3081851245 @default.
• W4366463211 cites W3092297248 @default.
• W4366463211 cites W3092720153 @default.
• W4366463211 cites W3093011007 @default.
• W4366463211 cites W3109911578 @default.
• W4366463211 cites W3120072441 @default.
• W4366463211 cites W3129547287 @default.
• W4366463211 cites W3139506724 @default.
• W4366463211 cites W3146717559 @default.
• W4366463211 cites W3154970472 @default.
• W4366463211 cites W3158403711 @default.
• W4366463211 cites W3160329729 @default.
• W4366463211 cites W3163504586 @default.
• W4366463211 cites W3163748820 @default.
• W4366463211 cites W3164469098 @default.
• W4366463211 cites W3170911976 @default.
• W4366463211 cites W3179621822 @default.
• W4366463211 cites W3184694394 @default.
• W4366463211 cites W3184828344 @default.
• W4366463211 cites W3189169221 @default.
• W4366463211 cites W3191063868 @default.
• W4366463211 cites W3193645017 @default.
• W4366463211 cites W3199306670 @default.
• W4366463211 cites W3199368172 @default.
• W4366463211 cites W3200655219 @default.
• W4366463211 cites W3202024205 @default.
• W4366463211 cites W3204739474 @default.
• W4366463211 cites W3206452667 @default.
• W4366463211 cites W3214426622 @default.
• W4366463211 cites W3215443005 @default.
• W4366463211 cites W4200010391 @default.
• W4366463211 cites W4200347977 @default.
• W4366463211 cites W4205661757 @default.
• W4366463211 cites W4205733561 @default.
• W4366463211 cites W4213435613 @default.
• W4366463211 cites W4214587214 @default.
• W4366463211 cites W4214893822 @default.
• W4366463211 cites W4220752468 @default.
• W4366463211 cites W4220937854 @default.
• W4366463211 cites W4220952536 @default.
• W4366463211 cites W4221109441 @default.
• W4366463211 cites W4223479650 @default.
• W4366463211 cites W4223975759 @default.
• W4366463211 cites W4225502810 @default.

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