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- W4366463404 abstract "In humans, odors are detected by ~400 functional olfactory receptor (OR) genes. The superfamily of functional OR genes can be further divided into tens of families. In large part, the OR genes have experienced extensive tandem duplications, which have led to gene gains and losses. However, whether different OR gene families have experienced distinct modes of gene duplication has yet to be reported. We conducted comparative genomic and evolutionary analyses for human functional OR genes. Based on analysis of human-mouse 1–1 orthologs, we found that human functional OR genes show higher-than-average evolutionary rates, and there are significant differences among families of functional OR genes. Via comparison with seven vertebrate outgroups, families of human functional OR genes show different extents of gene synteny conservation. Although the superfamily of human functional OR genes is enriched in tandem and proximal duplications, there are particular families which are enriched in segmental duplications. These findings suggest that human functional OR genes may be governed by different evolutionary mechanisms and that large-scale gene duplications have contributed to the early evolution of human functional OR genes." @default.
- W4366463404 created "2023-04-22" @default.
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- W4366463404 date "2023-04-20" @default.
- W4366463404 modified "2023-09-30" @default.
- W4366463404 title "Diverse evolutionary rates and gene duplication patterns among families of functional olfactory receptor genes in humans" @default.
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- W4366463404 doi "https://doi.org/10.1371/journal.pone.0282575" @default.
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