Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366463661> ?p ?o ?g. }
- W4366463661 endingPage "e0284123" @default.
- W4366463661 startingPage "e0284123" @default.
- W4366463661 abstract "Background The prevalence of aluminum (Al) intoxication has declined over the past 3 decades. However, different groups still report on the diagnosis of Al in bone. Prolonged and low-intensity exposures to Al may not be captured by serum Al measurements, preventing its proper diagnosis. We hypothesize that bone Al accumulation may be related to bone and cardiovascular events in the current Era. Aims To detect the diagnosis of bone Al accumulation; to explore bone and cardiovascular consequences of Al accumulation. Methods This is a sub-analysis of The Brazilian Registry of Bone Biopsy , a prospective, multicentre cohort, with a mean follow-up of 3.4 years, including patients with CKD undergoing bone biopsy; bone fracture and major cardiovascular events (MACE) were adjudicated; Al accumulation was identified by solochrome-azurine staining; history of previous Al accumulation was registered based on information provided by the nephrologist who performed the bone biopsy; bone histomorphometry parameters, clinical data, and general biochemistry were registered. Results 275 individuals were considered; 96 (35%) patients have diagnosed with bone Al accumulation and were younger [50 (41–56) vs . 55 (43–61) years; p = 0.026], had lower body mass index [23.5 (21.6–25.5) vs . 24.3 (22.1–27.8) kg/m 2 ; p = 0.017], higher dialysis vintage [108 (48–183) vs . 71 (28–132) months; p = 0.002], presented pruritus [23 (24%) vs . 20 (11%); p = 0.005], tendon rupture [7 (7%) vs . 3 (2%); p = 0.03) and bone pain [2 (0–3) vs . 0 (0–3) units; p = 0.02]. Logistic regression reveals that prior bone Al accumulation [OR: 4.517 (CI: 1.176–17.353); p = 0.03] and dialysis vintage [OR: 1.003 (CI: 1.000–1.007); p = 0.046] as independent determinants of bone Al accumulation; minor perturbations in dynamic bone parameters and no differences in bone fractures rate were noted; MACE was more prevalent in patients with bone Al accumulation [21 (34%) vs . 23 (18%) events; p = 0.016]. Cox regression shows the actual/prior diagnosis of bone Al accumulation and diabetes mellitus as independent predictors for MACE: [HR = 3.129 (CI: 1.439–6.804; p = 0.004) and HR = 2.785 (CI: 1.120–6.928; p = 0.028]. Conclusions An elevated proportion of patients have bone Al accumulation, associated with a greater prevalence of bone pain, tendon rupture, and pruritus; bone Al accumulation was associated with minor perturbations in renal osteodystrophy; actual/prior diagnosis of bone Al accumulation and diabetes mellitus were independent predictors for MACE." @default.
- W4366463661 created "2023-04-22" @default.
- W4366463661 creator A5000704932 @default.
- W4366463661 creator A5007690102 @default.
- W4366463661 creator A5026317118 @default.
- W4366463661 creator A5032326208 @default.
- W4366463661 creator A5037533231 @default.
- W4366463661 creator A5054256580 @default.
- W4366463661 creator A5061165906 @default.
- W4366463661 creator A5064295057 @default.
- W4366463661 creator A5067547798 @default.
- W4366463661 creator A5080263355 @default.
- W4366463661 creator A5085769260 @default.
- W4366463661 date "2023-04-20" @default.
- W4366463661 modified "2023-10-14" @default.
- W4366463661 title "Effect of aluminum accumulation on bone and cardiovascular risk in the current era" @default.
- W4366463661 cites W1677883022 @default.
- W4366463661 cites W1965675690 @default.
- W4366463661 cites W1977437643 @default.
- W4366463661 cites W1977645780 @default.
- W4366463661 cites W1987368114 @default.
- W4366463661 cites W1992662623 @default.
- W4366463661 cites W2011165786 @default.
- W4366463661 cites W2013484555 @default.
- W4366463661 cites W2017989968 @default.
- W4366463661 cites W2022539296 @default.
- W4366463661 cites W2022545999 @default.
- W4366463661 cites W2029652593 @default.
- W4366463661 cites W2047851655 @default.
- W4366463661 cites W2050266779 @default.
- W4366463661 cites W2050876915 @default.
- W4366463661 cites W2060195434 @default.
- W4366463661 cites W2092539562 @default.
- W4366463661 cites W2096425957 @default.
- W4366463661 cites W2108141716 @default.
- W4366463661 cites W2112224598 @default.
- W4366463661 cites W2114754776 @default.
- W4366463661 cites W2127092730 @default.
- W4366463661 cites W2130482173 @default.
- W4366463661 cites W2133850959 @default.
- W4366463661 cites W2138348543 @default.
- W4366463661 cites W2157510371 @default.
- W4366463661 cites W2172159264 @default.
- W4366463661 cites W2256422497 @default.
- W4366463661 cites W2294080015 @default.
- W4366463661 cites W2397778911 @default.
- W4366463661 cites W2416263531 @default.
- W4366463661 cites W2520908537 @default.
- W4366463661 cites W2545610338 @default.
- W4366463661 cites W2548549197 @default.
- W4366463661 cites W2768230749 @default.
- W4366463661 cites W2780743029 @default.
- W4366463661 cites W2884945435 @default.
- W4366463661 cites W2899972269 @default.
- W4366463661 cites W2901047660 @default.
- W4366463661 cites W2901550289 @default.
- W4366463661 cites W2935974816 @default.
- W4366463661 cites W3001938520 @default.
- W4366463661 cites W3008678813 @default.
- W4366463661 cites W3011082552 @default.
- W4366463661 cites W3114787157 @default.
- W4366463661 cites W3132020753 @default.
- W4366463661 cites W84242438 @default.
- W4366463661 doi "https://doi.org/10.1371/journal.pone.0284123" @default.
- W4366463661 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37079520" @default.
- W4366463661 hasPublicationYear "2023" @default.
- W4366463661 type Work @default.
- W4366463661 citedByCount "1" @default.
- W4366463661 countsByYear W43664636612023 @default.
- W4366463661 crossrefType "journal-article" @default.
- W4366463661 hasAuthorship W4366463661A5000704932 @default.
- W4366463661 hasAuthorship W4366463661A5007690102 @default.
- W4366463661 hasAuthorship W4366463661A5026317118 @default.
- W4366463661 hasAuthorship W4366463661A5032326208 @default.
- W4366463661 hasAuthorship W4366463661A5037533231 @default.
- W4366463661 hasAuthorship W4366463661A5054256580 @default.
- W4366463661 hasAuthorship W4366463661A5061165906 @default.
- W4366463661 hasAuthorship W4366463661A5064295057 @default.
- W4366463661 hasAuthorship W4366463661A5067547798 @default.
- W4366463661 hasAuthorship W4366463661A5080263355 @default.
- W4366463661 hasAuthorship W4366463661A5085769260 @default.
- W4366463661 hasBestOaLocation W43664636611 @default.
- W4366463661 hasConcept C126322002 @default.
- W4366463661 hasConcept C126838900 @default.
- W4366463661 hasConcept C126894567 @default.
- W4366463661 hasConcept C141071460 @default.
- W4366463661 hasConcept C170033053 @default.
- W4366463661 hasConcept C188816634 @default.
- W4366463661 hasConcept C2775934546 @default.
- W4366463661 hasConcept C2776441800 @default.
- W4366463661 hasConcept C71924100 @default.
- W4366463661 hasConceptScore W4366463661C126322002 @default.
- W4366463661 hasConceptScore W4366463661C126838900 @default.
- W4366463661 hasConceptScore W4366463661C126894567 @default.
- W4366463661 hasConceptScore W4366463661C141071460 @default.
- W4366463661 hasConceptScore W4366463661C170033053 @default.
- W4366463661 hasConceptScore W4366463661C188816634 @default.
- W4366463661 hasConceptScore W4366463661C2775934546 @default.