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• W4366481739 abstract "<sec> <title>BACKGROUND</title> Repetitive negative thinking (RNT) is a key transdiagnostic mechanism underpinning depression and anxiety. Using ‘just-in-time adaptive interventions’ via smartphones may disrupt RNT in real-time, providing targeted and personalized intervention. </sec> <sec> <title>OBJECTIVE</title> This pilot randomized controlled trial evaluated the feasibility, acceptability and preliminary clinical outcomes and mechanisms of Mello – a fully automated, personalized, transdiagnostic, mechanistic smartphone intervention targeting RNT in young people with depression and anxiety. </sec> <sec> <title>METHODS</title> Participants with heightened depression, anxiety and RNT, were recruited online via social media and randomized to receive Mello or a non-active control over a six-week intervention period. Assessments were completed online via zoom sessions at baseline, and 3- and 6-weeks post-baseline. </sec> <sec> <title>RESULTS</title> Findings supported feasibility and acceptability, with high rates of recruitment (N = 55), uptake (86% of eligible participants), and retention (95% at 6-weeks). Engagement was high with 90% and 59% of participants in the Mello condition still using the app during the third and sixth weeks respectively. Greater reductions in depression (Cohen’s d=0.50), anxiety (Cohen’s d=0.61) and RNT (Cohen’s d=0.87) were observed for Mello users versus control. Mediation analyses suggested that changes in depression and anxiety were accounted for by changes in RNT. </sec> <sec> <title>CONCLUSIONS</title> Results indicate that mechanistic, targeted and real-time technology-based solutions may provide scalable and effective interventions that advance treatment of youth mental ill-health. </sec> <sec> <title>CLINICALTRIAL</title> Australian New Zealand Clinical Trials Registry ACTRN12621001701819; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=362117 </sec>" @default.
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• W4366481739 date "2023-04-04" @default.
• W4366481739 modified "2023-10-14" @default.
• W4366481739 title "A personalized, transdiagnostic smartphone intervention targeting repetitive negative thinking in young people with depression and anxiety: Pilot randomized controlled trial of Mello (Preprint)" @default.
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• W4366481739 doi "https://doi.org/10.2196/preprints.47860" @default.
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