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• W4366495381 endingPage "7061" @default.
• W4366495381 startingPage "7053" @default.
• W4366495381 abstract "False positives and negatives in bioanalytical assays remain a persistent problem. Herein, a multifunctional photoelectrochemical (PEC) biosensor based on ZnIn2S4 (ZIS)/ZnS quantum dots (QDs)@Au-Ag-reversed photocurrent of Cu-metal-organic framework (MOF) coupled with CRISPR/Cas-12a-shearing was innovatively developed for assay of dual targets. First, Cu-MOF as a good PEC material shows cathodic photocurrent. Then, numerous ZIS/ZnS QDs were assembled to the Au-Ag nanoparticles (NPs) to prepare a stable and highly amplified signal probe, which can just match the energy level of Cu-MOFs and realized the polarity-reversed photocurrent of Cu-MOF for the first time. As the empty-core nanostructure of Au-Ag NPs has a high specific surface area and low material density, the bimetallic nanocrystal can much increase the reaction rate and improve the redox efficiency. When target CEA-produced cDNA opened the hairpin DNA (HP1 DNA) on the electrode, the ZIS/ZnS QDs@Au-Ag signal probe was conjugated to the electrode via DNA hybridization, achieving a significantly reversed PEC current for CEA detection. Moreover, the specific binding of kanamycin/aptamer generated the acDNA (activator), which can activate the trans-cleavage activity of the CRISPR-CAS12a system on ssDNA, so the signal probe was sheared and caused the obvious decrease of PEC signal for kanamycin detection. The newly developed ZIS/ZnS QDs@Au-Ag NPs displayed excellent PEC properties and reversed photocurrent to MOF and were combined with the unique CRISPR-Cas12a system to achieve sensitive detection of dual targets, which can open a new polarity-reversed PEC sensing platform for rapid and accurate analysis of multiple targets and can effectively avoid false positives results in clinical testing." @default.
• W4366495381 created "2023-04-22" @default.
• W4366495381 creator A5027902136 @default.
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• W4366495381 date "2023-04-20" @default.
• W4366495381 modified "2023-10-16" @default.
• W4366495381 title "Multifunctional Photoelectrochemical Biosensor Based on ZnIn₂S₄/ZnS QDs@Au–Ag-Reversed Photocurrent of Cu-Metal–Organic Framework Coupled with CRISPR/Cas-12a-Shearing for Assay of Dual Targets" @default.
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• W4366495381 doi "https://doi.org/10.1021/acs.analchem.3c00846" @default.
• W4366495381 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37080908" @default.
• W4366495381 hasPublicationYear "2023" @default.
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