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- W4366498145 endingPage "104496" @default.
- W4366498145 startingPage "104496" @default.
- W4366498145 abstract "Major challenges faced in anticancer therapy include inefficient therapeutic transportation to tumor cells and chemotherapy-associated toxicity with severe adverse drug reactions. In this context, recent advancements in supramolecular polymer (SMP) chemi-structures offer structurally infused anticancer elements into nanocarrier systems in addition to encapsulated chemotherapeutic agents for synergistically-enhanced anti-cancer therapy. Designated supramolecular frameworks are feasibly obtained via rapid synthetic processes and are bioengineered to self-assemble into various delivery forms like nanoparticles, nanomicelles, etc. to achieve desirable therapeutic properties such as encapsulation of hydrophobic (Doxorubicin) as well as hydrophilic drugs (Camptothecin, Magnolol, etc.), enhanced entrapment efficiency (>80%) and a sustained therapeutic profile (72 h). Cell-internalization is improved by incorporation of sensitive proteins (monoclonal antibodies) and genetic material (siRNA, siETS1, shRNA, etc.), Moreover, multistimuli-sensitive linkages like and functional moieties present in the SMP-composition automatically modulate the chemical structure of the carriers in tumor-specific parameters as acidic pH, elevated temperature, increased oxidative radicals, etc. as well as exogenous triggers like light, ultrasound, magnetic field and electric potential initiate the structural auto-modulation of carrier system to reduce therapy-associated toxicity and offer protection to non-cancerous cells. These biocompatible constructs emerge as the focus of theranostics with potential applications in biosensing for qualitative analysis, quantitative evaluation and effective anti-cancer therapy." @default.
- W4366498145 created "2023-04-22" @default.
- W4366498145 creator A5043396984 @default.
- W4366498145 creator A5049946223 @default.
- W4366498145 date "2023-06-01" @default.
- W4366498145 modified "2023-10-17" @default.
- W4366498145 title "Auto-modulated nanosupramolecular chemi-structures for anticancer therapy" @default.
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- W4366498145 doi "https://doi.org/10.1016/j.jddst.2023.104496" @default.
- W4366498145 hasPublicationYear "2023" @default.
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