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- W4366502646 abstract "Ziel/Aim For the understanding of tumortissue, tumor microenvironment (Tme) and tumor glucose metabolism, [18F]FDG PET/CT imaging technology has a fundamental importance. For the functional depiction of further properties of the Tme, such as possible pH changes in the extracellular Tme we used 4 Methoxybenzylamin (4MBA) bound to [18F]FDG. The bound 4MBA prevents the cellular uptake of [18F]FDG. 4MBA-[18F]FDG can be cleaved pH dependently and the free [18F]FDG can then be enriched in the cells. With this technology, we wanted to investigate noninvasively the in vivo correlation between the uptake of a pH sensitive PET tracer and changes of the extracellular pH in the Tme." @default.
- W4366502646 created "2023-04-22" @default.
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- W4366502646 date "2023-03-30" @default.
- W4366502646 modified "2023-10-18" @default.
- W4366502646 title "Strategies for PET Imaging in Acidic Tumor Microenvironments" @default.
- W4366502646 doi "https://doi.org/10.1055/s-0043-1766343" @default.
- W4366502646 hasPublicationYear "2023" @default.
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