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- W4366525417 endingPage "168114" @default.
- W4366525417 startingPage "168114" @default.
- W4366525417 abstract "Neurodegenerative diseases, such as Alzheimer’s and Parkinson’s, are characterized by several pathological features, including selective neuronal loss, aggregation of specific proteins, and chronic inflammation. Aging is the most critical risk factor of these disorders. However, the mechanism by which aging contributes to the pathogenesis of neurodegenerative diseases is not clearly understood. Cellular senescence is a cell state or fate in response to stimuli. It is typically associated with a series of changes in cellular phenotypes such as abnormal cellular metabolism and proteostasis, reactive oxygen species (ROS) production, and increased secretion of certain molecules via senescence-associated secretory phenotype (SASP). In this review, we discuss how cellular senescence contributes to brain aging and neurodegenerative diseases, and the relationship between protein aggregation and cellular senescence. Finally, we discuss the potential of senescence modifiers and senolytics in the treatment of neurodegenerative diseases." @default.
- W4366525417 created "2023-04-22" @default.
- W4366525417 creator A5033683951 @default.
- W4366525417 creator A5048748048 @default.
- W4366525417 creator A5071949326 @default.
- W4366525417 date "2023-06-01" @default.
- W4366525417 modified "2023-10-12" @default.
- W4366525417 title "Molecular Mechanisms of Cellular Senescence in Neurodegenerative Diseases" @default.
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