Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366525672> ?p ?o ?g. }
- W4366525672 endingPage "105191" @default.
- W4366525672 startingPage "105191" @default.
- W4366525672 abstract "Endogenous neurosteroids and synthetic neuroactive steroids (NAS) are important targets for therapeutic development in neuropsychiatric disorders. These steroids modulate major signaling systems in the brain and intracellular processes including inflammation, cellular stress and autophagy. In this review, we describe studies performed using unnatural enantiomers of key neurosteroids, which are physiochemically identical to their natural counterparts except for rotation of polarized light. These studies led to insights in how NAS interact with receptors, ion channels and intracellular sites of action. Certain effects of NAS show high enantioselectivity, consistent with actions in chiral environments and likely direct interactions with signaling proteins. Other effects show no enantioselectivity and even reverse enantioselectivity. The spectrum of effects of NAS enantiomers raises the possibility that these agents, once considered only as tools for preclinical studies, have therapeutic potential that complements and in some cases may exceed their natural counterparts. Here we review studies of NAS enantiomers from the perspective of their potential development as novel neurotherapeutics." @default.
- W4366525672 created "2023-04-22" @default.
- W4366525672 creator A5023589964 @default.
- W4366525672 creator A5038228169 @default.
- W4366525672 creator A5060600576 @default.
- W4366525672 creator A5067324638 @default.
- W4366525672 creator A5081481500 @default.
- W4366525672 creator A5088595477 @default.
- W4366525672 date "2023-06-01" @default.
- W4366525672 modified "2023-10-18" @default.
- W4366525672 title "Neurosteroid enantiomers as potentially novel neurotherapeutics" @default.
- W4366525672 cites W1884948268 @default.
- W4366525672 cites W1966722313 @default.
- W4366525672 cites W1967637141 @default.
- W4366525672 cites W1971486313 @default.
- W4366525672 cites W1972571151 @default.
- W4366525672 cites W1973428925 @default.
- W4366525672 cites W1976278777 @default.
- W4366525672 cites W1976707885 @default.
- W4366525672 cites W1978930461 @default.
- W4366525672 cites W1979793519 @default.
- W4366525672 cites W1980400183 @default.
- W4366525672 cites W1981864002 @default.
- W4366525672 cites W1983157748 @default.
- W4366525672 cites W1986166766 @default.
- W4366525672 cites W1989888504 @default.
- W4366525672 cites W1993889988 @default.
- W4366525672 cites W1996056304 @default.
- W4366525672 cites W1998933939 @default.
- W4366525672 cites W2003750313 @default.
- W4366525672 cites W2004501505 @default.
- W4366525672 cites W2004950881 @default.
- W4366525672 cites W2010838716 @default.
- W4366525672 cites W2014327444 @default.
- W4366525672 cites W2015901846 @default.
- W4366525672 cites W2017227716 @default.
- W4366525672 cites W2019201578 @default.
- W4366525672 cites W2021019017 @default.
- W4366525672 cites W2025687528 @default.
- W4366525672 cites W2031471554 @default.
- W4366525672 cites W2034076764 @default.
- W4366525672 cites W2034250634 @default.
- W4366525672 cites W2052906514 @default.
- W4366525672 cites W2055527954 @default.
- W4366525672 cites W2056097417 @default.
- W4366525672 cites W2058249635 @default.
- W4366525672 cites W2068178068 @default.
- W4366525672 cites W2070399516 @default.
- W4366525672 cites W2070510853 @default.
- W4366525672 cites W2070581367 @default.
- W4366525672 cites W2072716228 @default.
- W4366525672 cites W2073005420 @default.
- W4366525672 cites W2074924866 @default.
- W4366525672 cites W2079590715 @default.
- W4366525672 cites W2080544793 @default.
- W4366525672 cites W2083447043 @default.
- W4366525672 cites W2084331785 @default.
- W4366525672 cites W2084846774 @default.
- W4366525672 cites W2088232735 @default.
- W4366525672 cites W2094854629 @default.
- W4366525672 cites W2107433841 @default.
- W4366525672 cites W2112897543 @default.
- W4366525672 cites W2113217079 @default.
- W4366525672 cites W2117842413 @default.
- W4366525672 cites W2131132735 @default.
- W4366525672 cites W2131961672 @default.
- W4366525672 cites W2136019568 @default.
- W4366525672 cites W2138603529 @default.
- W4366525672 cites W2143042538 @default.
- W4366525672 cites W2144899453 @default.
- W4366525672 cites W2147863922 @default.
- W4366525672 cites W2148338304 @default.
- W4366525672 cites W2154344967 @default.
- W4366525672 cites W2159290407 @default.
- W4366525672 cites W2162400220 @default.
- W4366525672 cites W2163215105 @default.
- W4366525672 cites W2163405412 @default.
- W4366525672 cites W2172099208 @default.
- W4366525672 cites W2288653246 @default.
- W4366525672 cites W2306036017 @default.
- W4366525672 cites W2324837494 @default.
- W4366525672 cites W2330900922 @default.
- W4366525672 cites W2340823070 @default.
- W4366525672 cites W2345911396 @default.
- W4366525672 cites W2405366332 @default.
- W4366525672 cites W2521348437 @default.
- W4366525672 cites W2548202306 @default.
- W4366525672 cites W2740680044 @default.
- W4366525672 cites W2756488677 @default.
- W4366525672 cites W2759768254 @default.
- W4366525672 cites W2762264305 @default.
- W4366525672 cites W2767481521 @default.
- W4366525672 cites W2784436238 @default.
- W4366525672 cites W2790907647 @default.
- W4366525672 cites W2946461126 @default.
- W4366525672 cites W2948469272 @default.
- W4366525672 cites W2949375091 @default.
- W4366525672 cites W2955950503 @default.