FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366526231> ?p ?o ?g. }

• W4366526231 endingPage "e15585" @default.
• W4366526231 startingPage "e15585" @default.
• W4366526231 abstract "Transplantation of bone marrow mesenchymal stem cells (BMSCs) has a promising therapeutic efficiency for varieties of disorders caused by ischemia or reperfusion impairment. It has been shown that BMSCs can mitigate intestinal ischemia/reperfusion (I/R) injuries, but the underlying mechanism is still unclear. This study aimed at investigating the efficacy of BMSCs on the immune function of intestinal mucosal microenvironment after I/R injuries.Twenty adult Sprague-Dawley rats were randomly assigned to a treatment or a control group. All the rats underwent superior mesenteric artery clamping and unclamping. In the treatment group, BMSCs were implanted into the intestine of ten rats by direct submucosal injection whereas the other ten rats in the control group were injected with the same volume of saline. On the fourth and seventh day after BMSCs transplantation, intestinal samples were examined for the CD4 (CD4-positive T-lymphocytes)/CD8 (CD8-positive T-lymphocytes) ratio of the bowel mucosa via flow cytometry, and for the level of Interleukin-2 (IL-2), Interleukin-4 (IL-4) and Interleukin-6 (IL-6) via ELISA. Paneth cell counts and Secretory Immunoglobulin A (SIgA) level were examined via immunohistochemical (IHC) analysis. Real time PCR (RT-PCR) was used to detect the expression levels of tumor necrosis factor-α (TNF-α) and trypsinogen (Serine 2) (PRSS2) genes. White blood cell (WBC) count was measured by manual counting under the microscope.The CD4/CD8 ratio in the treatment group was significantly lower compared with that in the control group. The concentration of IL-2 and IL-6 was lower in the treatment group compared with the control group, while the level of IL-4 is the reverse between the two groups. The number of Paneth cells in intestinal mucosa increased significantly, while the level of SIgA in intestinal mucosa decreased significantly, after BMSCs transplantation. The gene expression levels of TNF-α and PRSS2 in intestinal mucosa of treatment group were significantly lower than those of control group. The WBC count in the treatment group was significantly lower than that in the control group.We identified immune-relevant molecular changes that may explain the mechanism of BMSCs transplantation efficacy in alleviating rat intestinal immune-barrier after I/R." @default.
• W4366526231 created "2023-04-22" @default.
• W4366526231 creator A5021471823 @default.
• W4366526231 creator A5030691366 @default.
• W4366526231 creator A5045272733 @default.
• W4366526231 creator A5081980021 @default.
• W4366526231 creator A5083466095 @default.
• W4366526231 creator A5090815103 @default.
• W4366526231 date "2023-05-01" @default.
• W4366526231 modified "2023-09-26" @default.
• W4366526231 title "The efficacy of bone marrow mesenchymal stem cells on rat intestinal immune-function injured by ischemia/reperfusion" @default.
• W4366526231 cites W1754398997 @default.
• W4366526231 cites W1965547342 @default.
• W4366526231 cites W1968734200 @default.
• W4366526231 cites W1985672713 @default.
• W4366526231 cites W1991707658 @default.
• W4366526231 cites W1993150792 @default.
• W4366526231 cites W2019256148 @default.
• W4366526231 cites W2031790029 @default.
• W4366526231 cites W2033583601 @default.
• W4366526231 cites W2037847767 @default.
• W4366526231 cites W2049226602 @default.
• W4366526231 cites W2061655890 @default.
• W4366526231 cites W2104298738 @default.
• W4366526231 cites W2106117542 @default.
• W4366526231 cites W2110918038 @default.
• W4366526231 cites W2114420064 @default.
• W4366526231 cites W2139865372 @default.
• W4366526231 cites W2142207476 @default.
• W4366526231 cites W2150210448 @default.
• W4366526231 cites W2158048826 @default.
• W4366526231 cites W2400704824 @default.
• W4366526231 cites W248572154 @default.
• W4366526231 cites W2552044748 @default.
• W4366526231 cites W2620991346 @default.
• W4366526231 cites W2830145191 @default.
• W4366526231 cites W2943233832 @default.
• W4366526231 cites W2983506070 @default.
• W4366526231 cites W3047298832 @default.
• W4366526231 cites W3048091259 @default.
• W4366526231 cites W3095985803 @default.
• W4366526231 cites W3097317180 @default.
• W4366526231 cites W3097945673 @default.
• W4366526231 cites W3104328405 @default.
• W4366526231 cites W3111824108 @default.
• W4366526231 cites W3137099357 @default.
• W4366526231 cites W3159151443 @default.
• W4366526231 cites W3173556670 @default.
• W4366526231 cites W3214658666 @default.
• W4366526231 cites W3216944928 @default.
• W4366526231 cites W4206017620 @default.
• W4366526231 cites W4220753472 @default.
• W4366526231 cites W4310077426 @default.
• W4366526231 cites W4310081024 @default.
• W4366526231 cites W4310082958 @default.
• W4366526231 doi "https://doi.org/10.1016/j.heliyon.2023.e15585" @default.
• W4366526231 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37131448" @default.
• W4366526231 hasPublicationYear "2023" @default.
• W4366526231 type Work @default.
• W4366526231 citedByCount "0" @default.
• W4366526231 crossrefType "journal-article" @default.
• W4366526231 hasAuthorship W4366526231A5021471823 @default.
• W4366526231 hasAuthorship W4366526231A5030691366 @default.
• W4366526231 hasAuthorship W4366526231A5045272733 @default.
• W4366526231 hasAuthorship W4366526231A5081980021 @default.
• W4366526231 hasAuthorship W4366526231A5083466095 @default.
• W4366526231 hasAuthorship W4366526231A5090815103 @default.
• W4366526231 hasBestOaLocation W43665262311 @default.
• W4366526231 hasConcept C126322002 @default.
• W4366526231 hasConcept C142724271 @default.
• W4366526231 hasConcept C16685009 @default.
• W4366526231 hasConcept C167672396 @default.
• W4366526231 hasConcept C198826908 @default.
• W4366526231 hasConcept C203014093 @default.
• W4366526231 hasConcept C2778690821 @default.
• W4366526231 hasConcept C2780007613 @default.
• W4366526231 hasConcept C2781046184 @default.
• W4366526231 hasConcept C2911091166 @default.
• W4366526231 hasConcept C3019368612 @default.
• W4366526231 hasConcept C71924100 @default.
• W4366526231 hasConcept C74172505 @default.
• W4366526231 hasConcept C8891405 @default.
• W4366526231 hasConceptScore W4366526231C126322002 @default.
• W4366526231 hasConceptScore W4366526231C142724271 @default.
• W4366526231 hasConceptScore W4366526231C16685009 @default.
• W4366526231 hasConceptScore W4366526231C167672396 @default.
• W4366526231 hasConceptScore W4366526231C198826908 @default.
• W4366526231 hasConceptScore W4366526231C203014093 @default.
• W4366526231 hasConceptScore W4366526231C2778690821 @default.
• W4366526231 hasConceptScore W4366526231C2780007613 @default.
• W4366526231 hasConceptScore W4366526231C2781046184 @default.
• W4366526231 hasConceptScore W4366526231C2911091166 @default.
• W4366526231 hasConceptScore W4366526231C3019368612 @default.
• W4366526231 hasConceptScore W4366526231C71924100 @default.
• W4366526231 hasConceptScore W4366526231C74172505 @default.
• W4366526231 hasConceptScore W4366526231C8891405 @default.
• W4366526231 hasFunder F4320308668 @default.
• W4366526231 hasFunder F4320326964 @default.

• next