Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366549623> ?p ?o ?g. }
- W4366549623 abstract "Atypical chemokine receptors (ACKRs) form a small subfamily of receptors (ACKR1–4) unable to trigger G protein-dependent signaling in response to their ligands. They do, however, play a crucial regulatory role in chemokine biology by capturing, scavenging or transporting chemokines, thereby regulating their availability and signaling through classical chemokine receptors. ACKRs add thus another layer of complexity to the intricate chemokine–receptor interaction network. Recently, targeted approaches and screening programs aiming at reassessing chemokine activity towards ACKRs identified several new pairings such as the dimeric CXCL12 with ACKR1, CXCL2, CXCL10 and CCL26 with ACKR2, the viral broad-spectrum chemokine vCCL2/vMIP-II, a range of opioid peptides and PAMP-12 with ACKR3 as well as CCL20 and CCL22 with ACKR4. Moreover, GPR182 (ACKR5) has been lately proposed as a new promiscuous atypical chemokine receptor with scavenging activity notably towards CXCL9, CXCL10, CXCL12 and CXCL13. Altogether, these findings reveal new degrees of complexity of the chemokine network and expand the panel of ACKR ligands and regulatory functions. In this minireview, we present and discuss these new pairings, their physiological and clinical relevance as well as the opportunities they open for targeting ACKRs in innovative therapeutic strategies." @default.
- W4366549623 created "2023-04-22" @default.
- W4366549623 creator A5003891420 @default.
- W4366549623 creator A5022850024 @default.
- W4366549623 creator A5023970380 @default.
- W4366549623 creator A5052327708 @default.
- W4366549623 creator A5054168512 @default.
- W4366549623 creator A5063188002 @default.
- W4366549623 creator A5077706372 @default.
- W4366549623 date "2023-04-20" @default.
- W4366549623 modified "2023-09-30" @default.
- W4366549623 title "New pairings and deorphanization among the atypical chemokine receptor family — physiological and clinical relevance" @default.
- W4366549623 cites W1019458012 @default.
- W4366549623 cites W1491310897 @default.
- W4366549623 cites W1508985019 @default.
- W4366549623 cites W1515527087 @default.
- W4366549623 cites W1517882557 @default.
- W4366549623 cites W1536303889 @default.
- W4366549623 cites W1538857721 @default.
- W4366549623 cites W1540141473 @default.
- W4366549623 cites W1555667651 @default.
- W4366549623 cites W178070940 @default.
- W4366549623 cites W1861735264 @default.
- W4366549623 cites W1890667195 @default.
- W4366549623 cites W1902035535 @default.
- W4366549623 cites W1911903347 @default.
- W4366549623 cites W1915016592 @default.
- W4366549623 cites W1922705469 @default.
- W4366549623 cites W1943679088 @default.
- W4366549623 cites W1957670006 @default.
- W4366549623 cites W1969027117 @default.
- W4366549623 cites W1977065670 @default.
- W4366549623 cites W1977091420 @default.
- W4366549623 cites W1979453376 @default.
- W4366549623 cites W1980753190 @default.
- W4366549623 cites W1981149366 @default.
- W4366549623 cites W1984462878 @default.
- W4366549623 cites W1985058351 @default.
- W4366549623 cites W1987000399 @default.
- W4366549623 cites W1989506590 @default.
- W4366549623 cites W1990779788 @default.
- W4366549623 cites W1993268616 @default.
- W4366549623 cites W1995483790 @default.
- W4366549623 cites W1996453015 @default.
- W4366549623 cites W1996990893 @default.
- W4366549623 cites W1998203652 @default.
- W4366549623 cites W2001092796 @default.
- W4366549623 cites W2004887716 @default.
- W4366549623 cites W2005203974 @default.
- W4366549623 cites W2008052942 @default.
- W4366549623 cites W2010239869 @default.
- W4366549623 cites W2010364386 @default.
- W4366549623 cites W2015198542 @default.
- W4366549623 cites W2016482852 @default.
- W4366549623 cites W2018173754 @default.
- W4366549623 cites W2019608331 @default.
- W4366549623 cites W2022756254 @default.
- W4366549623 cites W2025344438 @default.
- W4366549623 cites W2028488136 @default.
- W4366549623 cites W2029174607 @default.
- W4366549623 cites W2030490621 @default.
- W4366549623 cites W2042277916 @default.
- W4366549623 cites W2043520451 @default.
- W4366549623 cites W2047924033 @default.
- W4366549623 cites W2048378882 @default.
- W4366549623 cites W2048679579 @default.
- W4366549623 cites W2052834898 @default.
- W4366549623 cites W2054065515 @default.
- W4366549623 cites W2055200188 @default.
- W4366549623 cites W2061305995 @default.
- W4366549623 cites W2063139850 @default.
- W4366549623 cites W2070829779 @default.
- W4366549623 cites W2072138264 @default.
- W4366549623 cites W2072814903 @default.
- W4366549623 cites W2074847127 @default.
- W4366549623 cites W2086687315 @default.
- W4366549623 cites W2090279266 @default.
- W4366549623 cites W2090476586 @default.
- W4366549623 cites W2093347002 @default.
- W4366549623 cites W2101446463 @default.
- W4366549623 cites W2112087685 @default.
- W4366549623 cites W2120765433 @default.
- W4366549623 cites W2126653242 @default.
- W4366549623 cites W2137185835 @default.
- W4366549623 cites W2148163330 @default.
- W4366549623 cites W2153827357 @default.
- W4366549623 cites W2159597354 @default.
- W4366549623 cites W2159913536 @default.
- W4366549623 cites W2161580735 @default.
- W4366549623 cites W2161766823 @default.
- W4366549623 cites W2162302971 @default.
- W4366549623 cites W2164194120 @default.
- W4366549623 cites W2168749287 @default.
- W4366549623 cites W2171581347 @default.
- W4366549623 cites W2231861525 @default.
- W4366549623 cites W2236938876 @default.
- W4366549623 cites W2305178018 @default.
- W4366549623 cites W2336600423 @default.
- W4366549623 cites W2396682173 @default.
- W4366549623 cites W2410605652 @default.