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- W4366550014 abstract "Graves' disease (GD) is characterized by diffuse enlargement and overactivity of the thyroid gland, which may be accompanied by other physical symptoms. Among them, depression can dramatically damage patients' quality of life, yet its prevalence in GD has not received adequate attention. Some studies have established a strong correlation between GD and increased risk of depression, though the data from current study remains limited. The summary of mechanistic insights regarding GD and depression has underpinned possible pathways by which GD contributes to depression. In this review, we first summarized the clinical evidence that supported the increased prevalence of depression by GD. We then concentrated on the mechanistic findings related to the acceleration of depression in the context of GD, as mounting evidence has indicated that GD promotes the development of depression through various mechanisms, including triggering autoimmune responses, inducing hormonal disorders, and influencing the thyroid-gut-microbiome-brain axis. Finally, we briefly presented potential therapeutic approaches to decreasing the risk of depression among patients with GD." @default.
- W4366550014 created "2023-04-22" @default.
- W4366550014 creator A5016173294 @default.
- W4366550014 creator A5032241094 @default.
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- W4366550014 creator A5069139562 @default.
- W4366550014 creator A5074476476 @default.
- W4366550014 date "2023-04-20" @default.
- W4366550014 modified "2023-10-14" @default.
- W4366550014 title "Graves’ disease as a driver of depression: a mechanistic insight" @default.
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