FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366550464> ?p ?o ?g. }

• W4366550464 abstract "Bone defect repair by implanting bone substitute materials has been a common clinical treatment. With the understanding of substance-immune system interactions and increasing evidence indicating that the post-implantation immune response determines the fate of bone substitute materials, active modulation of host macrophage polarization is considered a promising strategy. However, whether the same regulatory effects exist when an individual immune system is altered with aging is unclear.In this study, we mechanistically investigated the effect of immunosenescence on the active regulation of macrophage polarization by establishing a cranial bone defect model in young and aged rats implanted with Bio-Oss®. Forty-eight young and 48 aged specific pathogen-free (SPF) male SD rats were randomly divided into two groups. In the experimental group, 20 μL of IL-4 (0.5 μg/mL) was injected locally on the third to seventh postoperative days, while an equal volume of PBS was injected in the control group. Specimens were collected at 1, 2, 6, and 12 weeks postoperatively, and bone regeneration at the defect site was evaluated by micro-CT, histomorphometry, immunohistochemistry, double-labeling immunofluorescence, and RT-qPCR.The application of exogenous IL-4 reduced activation of NLRP3 inflammasomes by promoting the polarization of M1 macrophages to M2 macrophages, thus promoting bone regeneration at the site of bone defects in aged rats. However, this effect was gradually weakened after the IL-4 intervention was discontinued.Our data confirmed that a strategy to regulate macrophage polarization is also feasible under conditions of immunosenescence, i.e., the local inflammatory microenvironment can be regulated by reducing M1-type macrophages. However, further experiments are needed to determine an exogenous IL-4 intervention that can maintain a more sustained effect." @default.
• W4366550464 created "2023-04-22" @default.
• W4366550464 creator A5020958165 @default.
• W4366550464 creator A5035339773 @default.
• W4366550464 creator A5040074073 @default.
• W4366550464 creator A5057370742 @default.
• W4366550464 creator A5073501391 @default.
• W4366550464 date "2023-04-20" @default.
• W4366550464 modified "2023-09-30" @default.
• W4366550464 title "The immunomodulatory effect of IL-4 accelerates bone substitute material-mediated osteogenesis in aged rats via NLRP3 inflammasome inhibition" @default.
• W4366550464 cites W1766723201 @default.
• W4366550464 cites W1780375982 @default.
• W4366550464 cites W1982012740 @default.
• W4366550464 cites W2049906701 @default.
• W4366550464 cites W2077796307 @default.
• W4366550464 cites W2089503694 @default.
• W4366550464 cites W2090563106 @default.
• W4366550464 cites W2103850847 @default.
• W4366550464 cites W2129446718 @default.
• W4366550464 cites W2209532584 @default.
• W4366550464 cites W2262141841 @default.
• W4366550464 cites W2291429897 @default.
• W4366550464 cites W2435513334 @default.
• W4366550464 cites W2538622696 @default.
• W4366550464 cites W2759696454 @default.
• W4366550464 cites W2779902212 @default.
• W4366550464 cites W2897714759 @default.
• W4366550464 cites W2899477607 @default.
• W4366550464 cites W2908211411 @default.
• W4366550464 cites W2925719198 @default.
• W4366550464 cites W2969984959 @default.
• W4366550464 cites W2980605977 @default.
• W4366550464 cites W2982895754 @default.
• W4366550464 cites W3003234183 @default.
• W4366550464 cites W3006750619 @default.
• W4366550464 cites W3012977956 @default.
• W4366550464 cites W3033048717 @default.
• W4366550464 cites W3034480402 @default.
• W4366550464 cites W3036265910 @default.
• W4366550464 cites W3049535451 @default.
• W4366550464 cites W3080115286 @default.
• W4366550464 cites W3118708117 @default.
• W4366550464 cites W3123653170 @default.
• W4366550464 cites W3161368393 @default.
• W4366550464 cites W3161474660 @default.
• W4366550464 cites W3163658375 @default.
• W4366550464 cites W3164270472 @default.
• W4366550464 cites W3169585910 @default.
• W4366550464 cites W3197663289 @default.
• W4366550464 cites W3213172227 @default.
• W4366550464 cites W3214068706 @default.
• W4366550464 cites W4200426598 @default.
• W4366550464 cites W4220747502 @default.
• W4366550464 cites W4223519428 @default.
• W4366550464 cites W4223565809 @default.
• W4366550464 doi "https://doi.org/10.3389/fimmu.2023.1121549" @default.
• W4366550464 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37153554" @default.
• W4366550464 hasPublicationYear "2023" @default.
• W4366550464 type Work @default.
• W4366550464 citedByCount "0" @default.
• W4366550464 crossrefType "journal-article" @default.
• W4366550464 hasAuthorship W4366550464A5020958165 @default.
• W4366550464 hasAuthorship W4366550464A5035339773 @default.
• W4366550464 hasAuthorship W4366550464A5040074073 @default.
• W4366550464 hasAuthorship W4366550464A5057370742 @default.
• W4366550464 hasAuthorship W4366550464A5073501391 @default.
• W4366550464 hasBestOaLocation W43665504641 @default.
• W4366550464 hasConcept C105702510 @default.
• W4366550464 hasConcept C126322002 @default.
• W4366550464 hasConcept C170493617 @default.
• W4366550464 hasConcept C185592680 @default.
• W4366550464 hasConcept C202751555 @default.
• W4366550464 hasConcept C203014093 @default.
• W4366550464 hasConcept C204232928 @default.
• W4366550464 hasConcept C26374806 @default.
• W4366550464 hasConcept C2776682551 @default.
• W4366550464 hasConcept C2776914184 @default.
• W4366550464 hasConcept C2777209026 @default.
• W4366550464 hasConcept C2779056147 @default.
• W4366550464 hasConcept C2779244956 @default.
• W4366550464 hasConcept C2779428903 @default.
• W4366550464 hasConcept C55493867 @default.
• W4366550464 hasConcept C71924100 @default.
• W4366550464 hasConcept C8337478 @default.
• W4366550464 hasConcept C88045685 @default.
• W4366550464 hasConcept C8891405 @default.
• W4366550464 hasConceptScore W4366550464C105702510 @default.
• W4366550464 hasConceptScore W4366550464C126322002 @default.
• W4366550464 hasConceptScore W4366550464C170493617 @default.
• W4366550464 hasConceptScore W4366550464C185592680 @default.
• W4366550464 hasConceptScore W4366550464C202751555 @default.
• W4366550464 hasConceptScore W4366550464C203014093 @default.
• W4366550464 hasConceptScore W4366550464C204232928 @default.
• W4366550464 hasConceptScore W4366550464C26374806 @default.
• W4366550464 hasConceptScore W4366550464C2776682551 @default.
• W4366550464 hasConceptScore W4366550464C2776914184 @default.
• W4366550464 hasConceptScore W4366550464C2777209026 @default.
• W4366550464 hasConceptScore W4366550464C2779056147 @default.
• W4366550464 hasConceptScore W4366550464C2779244956 @default.
• W4366550464 hasConceptScore W4366550464C2779428903 @default.

• next