Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366551146> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W4366551146 abstract "Walking is a slow gait which is particularly adaptable to meet internal or external needs and is prone to maladaptive alterations that lead to gait disorders. Alterations can affect speed, but also style (the way one walks). While slowed speed may signify the presence of a problem, style represents the hallmark essential for clinical classification of gait disorders. However, it has been challenging to objectively capture key stylistic features while uncovering neural substrates driving these features. Here we revealed brainstem hotspots that drive strikingly different walking styles by employing an unbiased mapping assay that combines quantitative walking signatures with focal, cell type specific activation. We found that activation of inhibitory neurons that mapped to the ventromedial caudal pons induced slow motion-like style. Activation of excitatory neurons that mapped to the ventromedial upper medulla induced shuffle-like style. Contrasting shifts in walking signatures distinguished these styles. Activation of inhibitory and excitatory neurons outside these territories or of serotonergic neurons modulated walking speed, but without walking signature shifts. Consistent with their contrasting modulatory actions, hotspots for slow-motion and shuffle-like gaits preferentially innervated different substrates. These findings lay the basis for new avenues to study mechanisms underlying (mal)adaptive walking styles and gait disorders." @default.
- W4366551146 created "2023-04-22" @default.
- W4366551146 creator A5007221136 @default.
- W4366551146 creator A5013384022 @default.
- W4366551146 creator A5013397732 @default.
- W4366551146 creator A5019098800 @default.
- W4366551146 creator A5042309755 @default.
- W4366551146 creator A5047421115 @default.
- W4366551146 creator A5072056366 @default.
- W4366551146 creator A5082948468 @default.
- W4366551146 date "2023-04-20" @default.
- W4366551146 modified "2023-09-26" @default.
- W4366551146 title "Contrasting walking styles map to discrete neural substrates in the mouse brainstem" @default.
- W4366551146 doi "https://doi.org/10.1101/2023.04.19.537568" @default.
- W4366551146 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37131768" @default.
- W4366551146 hasPublicationYear "2023" @default.
- W4366551146 type Work @default.
- W4366551146 citedByCount "0" @default.
- W4366551146 crossrefType "posted-content" @default.
- W4366551146 hasAuthorship W4366551146A5007221136 @default.
- W4366551146 hasAuthorship W4366551146A5013384022 @default.
- W4366551146 hasAuthorship W4366551146A5013397732 @default.
- W4366551146 hasAuthorship W4366551146A5019098800 @default.
- W4366551146 hasAuthorship W4366551146A5042309755 @default.
- W4366551146 hasAuthorship W4366551146A5047421115 @default.
- W4366551146 hasAuthorship W4366551146A5072056366 @default.
- W4366551146 hasAuthorship W4366551146A5082948468 @default.
- W4366551146 hasBestOaLocation W43665511461 @default.
- W4366551146 hasConcept C112592302 @default.
- W4366551146 hasConcept C151800584 @default.
- W4366551146 hasConcept C15744967 @default.
- W4366551146 hasConcept C169760540 @default.
- W4366551146 hasConcept C170493617 @default.
- W4366551146 hasConcept C17077164 @default.
- W4366551146 hasConcept C2775864247 @default.
- W4366551146 hasConcept C37000724 @default.
- W4366551146 hasConcept C551621295 @default.
- W4366551146 hasConcept C55493867 @default.
- W4366551146 hasConcept C71924100 @default.
- W4366551146 hasConcept C86803240 @default.
- W4366551146 hasConcept C99508421 @default.
- W4366551146 hasConceptScore W4366551146C112592302 @default.
- W4366551146 hasConceptScore W4366551146C151800584 @default.
- W4366551146 hasConceptScore W4366551146C15744967 @default.
- W4366551146 hasConceptScore W4366551146C169760540 @default.
- W4366551146 hasConceptScore W4366551146C170493617 @default.
- W4366551146 hasConceptScore W4366551146C17077164 @default.
- W4366551146 hasConceptScore W4366551146C2775864247 @default.
- W4366551146 hasConceptScore W4366551146C37000724 @default.
- W4366551146 hasConceptScore W4366551146C551621295 @default.
- W4366551146 hasConceptScore W4366551146C55493867 @default.
- W4366551146 hasConceptScore W4366551146C71924100 @default.
- W4366551146 hasConceptScore W4366551146C86803240 @default.
- W4366551146 hasConceptScore W4366551146C99508421 @default.
- W4366551146 hasLocation W43665511461 @default.
- W4366551146 hasLocation W43665511462 @default.
- W4366551146 hasOpenAccess W4366551146 @default.
- W4366551146 hasPrimaryLocation W43665511461 @default.
- W4366551146 hasRelatedWork W1998768495 @default.
- W4366551146 hasRelatedWork W2010233362 @default.
- W4366551146 hasRelatedWork W2044962914 @default.
- W4366551146 hasRelatedWork W2075385578 @default.
- W4366551146 hasRelatedWork W2751847892 @default.
- W4366551146 hasRelatedWork W3006582284 @default.
- W4366551146 hasRelatedWork W3148410686 @default.
- W4366551146 hasRelatedWork W3150161641 @default.
- W4366551146 hasRelatedWork W3159614036 @default.
- W4366551146 hasRelatedWork W4212915683 @default.
- W4366551146 isParatext "false" @default.
- W4366551146 isRetracted "false" @default.
- W4366551146 workType "article" @default.