FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366579051> ?p ?o ?g. }

• W4366579051 abstract "Abstract Background Central nervous system (CNS) active medications have been consistently linked to falls in older people. However, few randomized trials have evaluated whether CNS-active medication reduction reduces falls and fall-related injuries. The objective of the Reducing CNS-active Medications to Prevent Falls and Injuries in Older Adults (STOP-FALLS) trial is to test the effectiveness of a health-system-embedded deprescribing intervention focused on CNS-active medications on the incidence of medically treated falls among community-dwelling older adults. Methods We will conduct a pragmatic, cluster-randomized, parallel-group, controlled clinical trial within Kaiser Permanente Washington to test the effectiveness of a 12-month deprescribing intervention consisting of: 1) an educational brochure and self-care handouts mailed to older adults prescribed one or more CNS-active medications (aged 60+: opioids, benzodiazepines and Z-drugs; aged 65+: skeletal muscle relaxants, tricyclic antidepressants, and antihistamines) and 2) decision support for their primary health care providers. Outcomes are examined over 18–26 months post-intervention. The primary outcome is first incident (post-baseline) medically treated fall as determined from health plan data. Our sample size calculations ensure at least 80% power to detect a 20% reduction in the rate of medically treated falls for participants receiving care within the intervention (n = 9) versus usual care clinics (n = 9) assuming 18 months of follow-up. Secondary outcomes include medication discontinuation or dose reduction of any target medications. Safety outcomes include serious adverse drug withdrawal events, unintentional overdose, and death. We will also examine medication signetur fields for attempts to decrease medications. We will report factors affecting implementation of the intervention. Discussion The STOP-FALLS trial will provide new information about whether a health-system-embedded deprescribing intervention that targets older participants and their primary care providers reduces medically treated falls and CNS-active medication use. Insights into factors affecting implementation will inform future research and healthcare organizations that may be interested in replicating the intervention. Trial registration: clinicaltrial.gov: NCT05689554, registered 18 January 2023, retrospectively registered." @default.
• W4366579051 created "2023-04-23" @default.
• W4366579051 creator A5001121461 @default.
• W4366579051 creator A5009132887 @default.
• W4366579051 creator A5043182178 @default.
• W4366579051 creator A5045813790 @default.
• W4366579051 creator A5048844325 @default.
• W4366579051 creator A5068157685 @default.
• W4366579051 creator A5073761403 @default.
• W4366579051 creator A5077858588 @default.
• W4366579051 creator A5081374792 @default.
• W4366579051 creator A5087025716 @default.
• W4366579051 creator A5090374861 @default.
• W4366579051 date "2023-04-19" @default.
• W4366579051 modified "2023-10-18" @default.
• W4366579051 title "A health-system-embedded deprescribing intervention targeting patients and providers to prevent falls in older adults (STOP-FALLS trial): Study protocol for a pragmatic cluster-randomized controlled trial" @default.
• W4366579051 cites W2082921236 @default.
• W4366579051 cites W2094113973 @default.
• W4366579051 cites W2125610444 @default.
• W4366579051 cites W2127427656 @default.
• W4366579051 cites W2159372140 @default.
• W4366579051 cites W2294847536 @default.
• W4366579051 cites W2323544099 @default.
• W4366579051 cites W2324471062 @default.
• W4366579051 doi "https://doi.org/10.21203/rs.3.rs-2497340/v1" @default.
• W4366579051 hasPublicationYear "2023" @default.
• W4366579051 type Work @default.
• W4366579051 citedByCount "0" @default.
• W4366579051 crossrefType "posted-content" @default.
• W4366579051 hasAuthorship W4366579051A5001121461 @default.
• W4366579051 hasAuthorship W4366579051A5009132887 @default.
• W4366579051 hasAuthorship W4366579051A5043182178 @default.
• W4366579051 hasAuthorship W4366579051A5045813790 @default.
• W4366579051 hasAuthorship W4366579051A5048844325 @default.
• W4366579051 hasAuthorship W4366579051A5068157685 @default.
• W4366579051 hasAuthorship W4366579051A5073761403 @default.
• W4366579051 hasAuthorship W4366579051A5077858588 @default.
• W4366579051 hasAuthorship W4366579051A5081374792 @default.
• W4366579051 hasAuthorship W4366579051A5087025716 @default.
• W4366579051 hasAuthorship W4366579051A5090374861 @default.
• W4366579051 hasBestOaLocation W43665790511 @default.
• W4366579051 hasConcept C118552586 @default.
• W4366579051 hasConcept C126322002 @default.
• W4366579051 hasConcept C168563851 @default.
• W4366579051 hasConcept C176400912 @default.
• W4366579051 hasConcept C177713679 @default.
• W4366579051 hasConcept C1862650 @default.
• W4366579051 hasConcept C194828623 @default.
• W4366579051 hasConcept C197934379 @default.
• W4366579051 hasConcept C2776484012 @default.
• W4366579051 hasConcept C2778715236 @default.
• W4366579051 hasConcept C2780665704 @default.
• W4366579051 hasConcept C3017944768 @default.
• W4366579051 hasConcept C36434225 @default.
• W4366579051 hasConcept C71924100 @default.
• W4366579051 hasConceptScore W4366579051C118552586 @default.
• W4366579051 hasConceptScore W4366579051C126322002 @default.
• W4366579051 hasConceptScore W4366579051C168563851 @default.
• W4366579051 hasConceptScore W4366579051C176400912 @default.
• W4366579051 hasConceptScore W4366579051C177713679 @default.
• W4366579051 hasConceptScore W4366579051C1862650 @default.
• W4366579051 hasConceptScore W4366579051C194828623 @default.
• W4366579051 hasConceptScore W4366579051C197934379 @default.
• W4366579051 hasConceptScore W4366579051C2776484012 @default.
• W4366579051 hasConceptScore W4366579051C2778715236 @default.
• W4366579051 hasConceptScore W4366579051C2780665704 @default.
• W4366579051 hasConceptScore W4366579051C3017944768 @default.
• W4366579051 hasConceptScore W4366579051C36434225 @default.
• W4366579051 hasConceptScore W4366579051C71924100 @default.
• W4366579051 hasLocation W43665790511 @default.
• W4366579051 hasOpenAccess W4366579051 @default.
• W4366579051 hasPrimaryLocation W43665790511 @default.
• W4366579051 hasRelatedWork W2206327969 @default.
• W4366579051 hasRelatedWork W2438556286 @default.
• W4366579051 hasRelatedWork W2739744586 @default.
• W4366579051 hasRelatedWork W2971212883 @default.
• W4366579051 hasRelatedWork W3003369214 @default.
• W4366579051 hasRelatedWork W3007949848 @default.
• W4366579051 hasRelatedWork W3157629480 @default.
• W4366579051 hasRelatedWork W4296801178 @default.
• W4366579051 hasRelatedWork W4381716168 @default.
• W4366579051 hasRelatedWork W4386877752 @default.
• W4366579051 isParatext "false" @default.
• W4366579051 isRetracted "false" @default.
• W4366579051 workType "article" @default.