Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366579420> ?p ?o ?g. }
- W4366579420 endingPage "94" @default.
- W4366579420 startingPage "72" @default.
- W4366579420 abstract "Reinventing approved therapeutic proteins for a new dose, a new formulation, a new route of administration, an improved safety profile, a new indication, or a new conjugate with a drug or a radioactive source is a creative approach to benefit from the billions spent on developing new therapeutic proteins. These new opportunities were created only recently with the arrival of AI/ML tools and high throughput screening technologies. Furthermore, the complex nature of proteins offers mining opportunities that are not possible with chemical drugs; bringing in newer therapies without spending billions makes this path highly lucrative financially while serving the dire needs of humanity. This paper analyzes several practical reinventing approaches and suggests regulatory strategies to reduce development costs significantly. This should enable the entry of hundreds of new therapies at affordable costs." @default.
- W4366579420 created "2023-04-23" @default.
- W4366579420 creator A5020219914 @default.
- W4366579420 creator A5054525075 @default.
- W4366579420 date "2023-04-19" @default.
- W4366579420 modified "2023-09-30" @default.
- W4366579420 title "Reinventing Therapeutic Proteins: Mining a Treasure of New Therapies" @default.
- W4366579420 cites W1527782499 @default.
- W4366579420 cites W1547437295 @default.
- W4366579420 cites W1595347157 @default.
- W4366579420 cites W1656114533 @default.
- W4366579420 cites W166486881 @default.
- W4366579420 cites W1968590850 @default.
- W4366579420 cites W1971021060 @default.
- W4366579420 cites W1980999468 @default.
- W4366579420 cites W1983304433 @default.
- W4366579420 cites W1985588649 @default.
- W4366579420 cites W1987134040 @default.
- W4366579420 cites W1988744515 @default.
- W4366579420 cites W2009400274 @default.
- W4366579420 cites W2014921891 @default.
- W4366579420 cites W2015228718 @default.
- W4366579420 cites W2025938842 @default.
- W4366579420 cites W2028440694 @default.
- W4366579420 cites W2032864321 @default.
- W4366579420 cites W2034609970 @default.
- W4366579420 cites W2037312364 @default.
- W4366579420 cites W2042572511 @default.
- W4366579420 cites W2050456292 @default.
- W4366579420 cites W2050622711 @default.
- W4366579420 cites W2059168512 @default.
- W4366579420 cites W2072958011 @default.
- W4366579420 cites W2087729059 @default.
- W4366579420 cites W2094803175 @default.
- W4366579420 cites W2096210342 @default.
- W4366579420 cites W2111653877 @default.
- W4366579420 cites W2115167726 @default.
- W4366579420 cites W2118167053 @default.
- W4366579420 cites W2120871937 @default.
- W4366579420 cites W2136451426 @default.
- W4366579420 cites W2140000393 @default.
- W4366579420 cites W2145044799 @default.
- W4366579420 cites W2147396398 @default.
- W4366579420 cites W2147472674 @default.
- W4366579420 cites W2148090354 @default.
- W4366579420 cites W2156506990 @default.
- W4366579420 cites W2166395811 @default.
- W4366579420 cites W2170179543 @default.
- W4366579420 cites W2189911347 @default.
- W4366579420 cites W2248346391 @default.
- W4366579420 cites W2252006103 @default.
- W4366579420 cites W2269860277 @default.
- W4366579420 cites W2283151873 @default.
- W4366579420 cites W2314634510 @default.
- W4366579420 cites W2362265365 @default.
- W4366579420 cites W2462507877 @default.
- W4366579420 cites W2493718103 @default.
- W4366579420 cites W2532646138 @default.
- W4366579420 cites W2557595285 @default.
- W4366579420 cites W2558217333 @default.
- W4366579420 cites W2586724023 @default.
- W4366579420 cites W2588514765 @default.
- W4366579420 cites W2588635793 @default.
- W4366579420 cites W2598265731 @default.
- W4366579420 cites W2621361707 @default.
- W4366579420 cites W2625186389 @default.
- W4366579420 cites W2739172437 @default.
- W4366579420 cites W2739980134 @default.
- W4366579420 cites W2747592475 @default.
- W4366579420 cites W2756160532 @default.
- W4366579420 cites W2756479018 @default.
- W4366579420 cites W2763537431 @default.
- W4366579420 cites W2765609047 @default.
- W4366579420 cites W2766822634 @default.
- W4366579420 cites W2768717631 @default.
- W4366579420 cites W2772078663 @default.
- W4366579420 cites W2783204748 @default.
- W4366579420 cites W2785947426 @default.
- W4366579420 cites W2797614979 @default.
- W4366579420 cites W2804822363 @default.
- W4366579420 cites W2884323962 @default.
- W4366579420 cites W2886809304 @default.
- W4366579420 cites W2892032010 @default.
- W4366579420 cites W2893435209 @default.
- W4366579420 cites W2899145959 @default.
- W4366579420 cites W2901411193 @default.
- W4366579420 cites W2911775629 @default.
- W4366579420 cites W2921965627 @default.
- W4366579420 cites W2933991772 @default.
- W4366579420 cites W2934022420 @default.
- W4366579420 cites W2941450171 @default.
- W4366579420 cites W2942229510 @default.
- W4366579420 cites W2952138473 @default.
- W4366579420 cites W2954868841 @default.
- W4366579420 cites W2959938226 @default.
- W4366579420 cites W2960989010 @default.
- W4366579420 cites W2982411421 @default.
- W4366579420 cites W2985379037 @default.