Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366590381> ?p ?o ?g. }
- W4366590381 endingPage "753" @default.
- W4366590381 startingPage "734" @default.
- W4366590381 abstract "Abstract Multiple myeloma (MM) is a plasma cell malignancy defined by complex genetics and extensive patient heterogeneity. Despite a growing arsenal of approved therapies, MM remains incurable and in need of guidelines to identify effective personalized treatments. Here, we survey the ex vivo drug and immunotherapy sensitivities across 101 bone marrow samples from 70 patients with MM using multiplexed immunofluorescence, automated microscopy and deep-learning-based single-cell phenotyping. Combined with sample-matched genetics, proteotyping and cytokine profiling, we map the molecular regulatory network of drug sensitivity, implicating the DNA repair pathway and EYA3 expression in proteasome inhibitor sensitivity and major histocompatibility complex class II expression in the response to elotuzumab. Globally, ex vivo drug sensitivity associated with bone marrow microenvironmental signatures reflecting treatment stage, clonality and inflammation. Furthermore, ex vivo drug sensitivity significantly stratified clinical treatment responses, including to immunotherapy. Taken together, our study provides molecular and actionable insights into diverse treatment strategies for patients with MM." @default.
- W4366590381 created "2023-04-23" @default.
- W4366590381 creator A5000370363 @default.
- W4366590381 creator A5002696803 @default.
- W4366590381 creator A5002968128 @default.
- W4366590381 creator A5008095018 @default.
- W4366590381 creator A5012660985 @default.
- W4366590381 creator A5020225253 @default.
- W4366590381 creator A5027237229 @default.
- W4366590381 creator A5037650942 @default.
- W4366590381 creator A5038565479 @default.
- W4366590381 creator A5046176713 @default.
- W4366590381 creator A5051334364 @default.
- W4366590381 creator A5064517124 @default.
- W4366590381 creator A5070272273 @default.
- W4366590381 creator A5074131935 @default.
- W4366590381 date "2023-04-20" @default.
- W4366590381 modified "2023-10-17" @default.
- W4366590381 title "Ex vivo drug response heterogeneity reveals personalized therapeutic strategies for patients with multiple myeloma" @default.
- W4366590381 cites W134083461 @default.
- W4366590381 cites W1585625390 @default.
- W4366590381 cites W1902692042 @default.
- W4366590381 cites W1933867057 @default.
- W4366590381 cites W1981403111 @default.
- W4366590381 cites W1996243898 @default.
- W4366590381 cites W1998025335 @default.
- W4366590381 cites W2004543856 @default.
- W4366590381 cites W2019405732 @default.
- W4366590381 cites W2039180923 @default.
- W4366590381 cites W2046517086 @default.
- W4366590381 cites W2050709564 @default.
- W4366590381 cites W2056920544 @default.
- W4366590381 cites W2059581635 @default.
- W4366590381 cites W2063355387 @default.
- W4366590381 cites W2064572300 @default.
- W4366590381 cites W2070739194 @default.
- W4366590381 cites W2076680628 @default.
- W4366590381 cites W2101035019 @default.
- W4366590381 cites W2101083009 @default.
- W4366590381 cites W2105381419 @default.
- W4366590381 cites W2107554012 @default.
- W4366590381 cites W2111163979 @default.
- W4366590381 cites W2121503734 @default.
- W4366590381 cites W2124240218 @default.
- W4366590381 cites W2128644254 @default.
- W4366590381 cites W2146415848 @default.
- W4366590381 cites W2149877193 @default.
- W4366590381 cites W2152776755 @default.
- W4366590381 cites W2174635591 @default.
- W4366590381 cites W2194775991 @default.
- W4366590381 cites W2201190784 @default.
- W4366590381 cites W2215798291 @default.
- W4366590381 cites W2222753116 @default.
- W4366590381 cites W2461427403 @default.
- W4366590381 cites W2511571730 @default.
- W4366590381 cites W2512106959 @default.
- W4366590381 cites W2528329272 @default.
- W4366590381 cites W2581891628 @default.
- W4366590381 cites W2604776612 @default.
- W4366590381 cites W2609170929 @default.
- W4366590381 cites W2610843455 @default.
- W4366590381 cites W2613844594 @default.
- W4366590381 cites W2755635857 @default.
- W4366590381 cites W2755732362 @default.
- W4366590381 cites W2769605488 @default.
- W4366590381 cites W2791971573 @default.
- W4366590381 cites W2799981419 @default.
- W4366590381 cites W2900032527 @default.
- W4366590381 cites W2902162324 @default.
- W4366590381 cites W2943284016 @default.
- W4366590381 cites W2947871247 @default.
- W4366590381 cites W2953981972 @default.
- W4366590381 cites W2969936963 @default.
- W4366590381 cites W2990612043 @default.
- W4366590381 cites W3012172792 @default.
- W4366590381 cites W3018331841 @default.
- W4366590381 cites W3018581552 @default.
- W4366590381 cites W3093407181 @default.
- W4366590381 cites W3107527779 @default.
- W4366590381 cites W3133251387 @default.
- W4366590381 cites W3158345122 @default.
- W4366590381 cites W3158477759 @default.
- W4366590381 cites W3162540819 @default.
- W4366590381 cites W3163260996 @default.
- W4366590381 cites W3166205381 @default.
- W4366590381 cites W3205761999 @default.
- W4366590381 cites W3212953701 @default.
- W4366590381 cites W3214427435 @default.
- W4366590381 cites W4210508051 @default.
- W4366590381 cites W4210734847 @default.
- W4366590381 cites W4211058750 @default.
- W4366590381 cites W4211191410 @default.
- W4366590381 cites W4214608900 @default.
- W4366590381 cites W4289638315 @default.
- W4366590381 cites W4293493284 @default.
- W4366590381 cites W4296784527 @default.
- W4366590381 cites W4307930377 @default.
- W4366590381 doi "https://doi.org/10.1038/s43018-023-00544-9" @default.