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- W4366591208 startingPage "7556" @default.
- W4366591208 abstract "Fibroblast growth factors (FGFs) encode a large family of growth factor proteins that activate several intracellular signaling pathways to control diverse physiological functions. The human genome encodes 22 FGFs that share a high sequence and structural homology with those of other vertebrates. FGFs orchestrate diverse biological functions by regulating cellular differentiation, proliferation, and migration. Dysregulated FGF signaling may contribute to several pathological conditions, including cancer. Notably, FGFs exhibit wide functional diversity among different vertebrates spatiotemporally. A comparative study of FGF receptor ligands and their diverse roles in vertebrates ranging from embryonic development to pathological conditions may expand our understanding of FGF. Moreover, targeting diverse FGF signals requires knowledge regarding their structural and functional heterogeneity among vertebrates. This study summarizes the current understanding of human FGF signals and correlates them with those in mouse and Xenopus models, thereby facilitating the identification of therapeutic targets for various human disorders." @default.
- W4366591208 created "2023-04-23" @default.
- W4366591208 creator A5001142072 @default.
- W4366591208 creator A5007557540 @default.
- W4366591208 creator A5068373146 @default.
- W4366591208 creator A5084226421 @default.
- W4366591208 date "2023-04-20" @default.
- W4366591208 modified "2023-10-14" @default.
- W4366591208 title "Exploring the Structural and Functional Diversity among FGF Signals: A Comparative Study of Human, Mouse, and Xenopus FGF Ligands in Embryonic Development and Cancer Pathogenesis" @default.
- W4366591208 cites W1513451331 @default.
- W4366591208 cites W1527661581 @default.
- W4366591208 cites W1534863661 @default.
- W4366591208 cites W1552332385 @default.
- W4366591208 cites W1555526329 @default.
- W4366591208 cites W1563425273 @default.
- W4366591208 cites W1576992587 @default.
- W4366591208 cites W1644276928 @default.
- W4366591208 cites W1839390453 @default.
- W4366591208 cites W1859089489 @default.
- W4366591208 cites W1866095424 @default.
- W4366591208 cites W1922106993 @default.
- W4366591208 cites W1964823824 @default.
- W4366591208 cites W1965358479 @default.
- W4366591208 cites W1965634661 @default.
- W4366591208 cites W1966120773 @default.
- W4366591208 cites W1966181749 @default.
- W4366591208 cites W1968091833 @default.
- W4366591208 cites W1974873948 @default.
- W4366591208 cites W1976348644 @default.
- W4366591208 cites W1981088384 @default.
- W4366591208 cites W1985023917 @default.
- W4366591208 cites W1985737377 @default.
- W4366591208 cites W1986001179 @default.
- W4366591208 cites W1986215989 @default.
- W4366591208 cites W1988215259 @default.
- W4366591208 cites W1991653577 @default.
- W4366591208 cites W1996958662 @default.
- W4366591208 cites W1998905221 @default.
- W4366591208 cites W2000368348 @default.
- W4366591208 cites W2002494594 @default.
- W4366591208 cites W2003905949 @default.
- W4366591208 cites W2005322337 @default.
- W4366591208 cites W2006136865 @default.
- W4366591208 cites W2007287339 @default.
- W4366591208 cites W2012179510 @default.
- W4366591208 cites W2014389623 @default.
- W4366591208 cites W2015726066 @default.
- W4366591208 cites W2015881246 @default.
- W4366591208 cites W2020298328 @default.
- W4366591208 cites W2022095980 @default.
- W4366591208 cites W2025183773 @default.
- W4366591208 cites W2025398227 @default.
- W4366591208 cites W2026663929 @default.
- W4366591208 cites W2027399729 @default.
- W4366591208 cites W2032238268 @default.
- W4366591208 cites W2034198983 @default.
- W4366591208 cites W2038397615 @default.
- W4366591208 cites W2039291533 @default.
- W4366591208 cites W2039358114 @default.
- W4366591208 cites W2041230353 @default.
- W4366591208 cites W2042203151 @default.
- W4366591208 cites W2042814330 @default.
- W4366591208 cites W2043958868 @default.
- W4366591208 cites W2047796522 @default.
- W4366591208 cites W2048285167 @default.
- W4366591208 cites W2048508307 @default.
- W4366591208 cites W2048850448 @default.
- W4366591208 cites W2052881221 @default.
- W4366591208 cites W2054151200 @default.
- W4366591208 cites W2054195724 @default.
- W4366591208 cites W2055172928 @default.
- W4366591208 cites W2058310481 @default.
- W4366591208 cites W2059524152 @default.
- W4366591208 cites W2061668856 @default.
- W4366591208 cites W2062233225 @default.
- W4366591208 cites W2062842771 @default.
- W4366591208 cites W2063746351 @default.
- W4366591208 cites W2064125892 @default.
- W4366591208 cites W2065707615 @default.
- W4366591208 cites W2068092421 @default.
- W4366591208 cites W2068909924 @default.
- W4366591208 cites W2071296318 @default.
- W4366591208 cites W2072303535 @default.
- W4366591208 cites W2073184175 @default.
- W4366591208 cites W2075115786 @default.
- W4366591208 cites W2075500765 @default.
- W4366591208 cites W2076098007 @default.
- W4366591208 cites W2079509173 @default.
- W4366591208 cites W2081554709 @default.
- W4366591208 cites W2083422904 @default.
- W4366591208 cites W2085882475 @default.
- W4366591208 cites W2086889008 @default.
- W4366591208 cites W2089735482 @default.
- W4366591208 cites W2091343301 @default.
- W4366591208 cites W2091362392 @default.
- W4366591208 cites W2091630371 @default.
- W4366591208 cites W2093291689 @default.
- W4366591208 cites W2094373933 @default.