Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366598368> ?p ?o ?g. }
- W4366598368 endingPage "1982" @default.
- W4366598368 startingPage "1982" @default.
- W4366598368 abstract "Gut microbiota is believed to be a major determinant of health outcomes. We hypothesised that a novel oral microbiome formula (SIM01) can reduce the risk of adverse health outcomes in at-risk subjects during the coronavirus disease 2019 (COVID-19) pandemic. In this single-centre, double-blind, randomised, placebo-controlled trial, we recruited subjects aged ≥65 years or with type two diabetes mellitus. Eligible subjects were randomised in a 1:1 ratio to receive three months of SIM01 or placebo (vitamin C) within one week of the first COVID-19 vaccine dose. Both the researchers and participants were blinded to the groups allocated. The rate of adverse health outcomes was significantly lower in the SIM01 group than the placebo at one month (6 [2.9%] vs. 25 [12.6], p < 0.001) and three months (0 vs. 5 [3.1%], p = 0.025). At three months, more subjects who received SIM01 than the placebo reported better sleep quality (53 [41.4%] vs. 22 [19.3%], p < 0.001), improved skin condition (18 [14.1%] vs. 8 [7.0%], p = 0.043), and better mood (27 [21.2%] vs. 13 [11.4%], p = 0.043). Subjects who received SIM01 showed a significant increase in beneficial Bifidobacteria and butyrate-producing bacteria in faecal samples and strengthened the microbial ecology network. SIM01 reduced adverse health outcomes and restored gut dysbiosis in elderly and diabetes patients during the COVID-19 pandemic." @default.
- W4366598368 created "2023-04-23" @default.
- W4366598368 creator A5015559872 @default.
- W4366598368 creator A5020065996 @default.
- W4366598368 creator A5023101751 @default.
- W4366598368 creator A5033655728 @default.
- W4366598368 creator A5036756715 @default.
- W4366598368 creator A5040473359 @default.
- W4366598368 creator A5043503140 @default.
- W4366598368 creator A5052621259 @default.
- W4366598368 creator A5054241031 @default.
- W4366598368 creator A5064922279 @default.
- W4366598368 creator A5066654486 @default.
- W4366598368 creator A5070020615 @default.
- W4366598368 creator A5081987954 @default.
- W4366598368 creator A5082379687 @default.
- W4366598368 date "2023-04-20" @default.
- W4366598368 modified "2023-09-25" @default.
- W4366598368 title "Effects of Gut Microbiome Modulation on Reducing Adverse Health Outcomes among Elderly and Diabetes Patients during the COVID-19 Pandemic: A Randomised, Double-Blind, Placebo-Controlled Trial (IMPACT Study)" @default.
- W4366598368 cites W1978356392 @default.
- W4366598368 cites W1979281993 @default.
- W4366598368 cites W2006862991 @default.
- W4366598368 cites W2027224691 @default.
- W4366598368 cites W2159286718 @default.
- W4366598368 cites W2482698601 @default.
- W4366598368 cites W2593928562 @default.
- W4366598368 cites W2616457137 @default.
- W4366598368 cites W2616825195 @default.
- W4366598368 cites W2756945639 @default.
- W4366598368 cites W2805498616 @default.
- W4366598368 cites W3004442407 @default.
- W4366598368 cites W3014294089 @default.
- W4366598368 cites W3024312732 @default.
- W4366598368 cites W3032629753 @default.
- W4366598368 cites W3118579072 @default.
- W4366598368 cites W3128663388 @default.
- W4366598368 cites W3132492176 @default.
- W4366598368 cites W3165783964 @default.
- W4366598368 cites W3180893219 @default.
- W4366598368 cites W3211878530 @default.
- W4366598368 cites W4210905723 @default.
- W4366598368 cites W4213171373 @default.
- W4366598368 cites W4290722134 @default.
- W4366598368 cites W4296087453 @default.
- W4366598368 cites W4307232282 @default.
- W4366598368 doi "https://doi.org/10.3390/nu15081982" @default.
- W4366598368 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37111201" @default.
- W4366598368 hasPublicationYear "2023" @default.
- W4366598368 type Work @default.
- W4366598368 citedByCount "1" @default.
- W4366598368 countsByYear W43665983682023 @default.
- W4366598368 crossrefType "journal-article" @default.
- W4366598368 hasAuthorship W4366598368A5015559872 @default.
- W4366598368 hasAuthorship W4366598368A5020065996 @default.
- W4366598368 hasAuthorship W4366598368A5023101751 @default.
- W4366598368 hasAuthorship W4366598368A5033655728 @default.
- W4366598368 hasAuthorship W4366598368A5036756715 @default.
- W4366598368 hasAuthorship W4366598368A5040473359 @default.
- W4366598368 hasAuthorship W4366598368A5043503140 @default.
- W4366598368 hasAuthorship W4366598368A5052621259 @default.
- W4366598368 hasAuthorship W4366598368A5054241031 @default.
- W4366598368 hasAuthorship W4366598368A5064922279 @default.
- W4366598368 hasAuthorship W4366598368A5066654486 @default.
- W4366598368 hasAuthorship W4366598368A5070020615 @default.
- W4366598368 hasAuthorship W4366598368A5081987954 @default.
- W4366598368 hasAuthorship W4366598368A5082379687 @default.
- W4366598368 hasBestOaLocation W43665983681 @default.
- W4366598368 hasConcept C126322002 @default.
- W4366598368 hasConcept C134018914 @default.
- W4366598368 hasConcept C142724271 @default.
- W4366598368 hasConcept C168563851 @default.
- W4366598368 hasConcept C197934379 @default.
- W4366598368 hasConcept C204787440 @default.
- W4366598368 hasConcept C27081682 @default.
- W4366598368 hasConcept C2779134260 @default.
- W4366598368 hasConcept C3008058167 @default.
- W4366598368 hasConcept C524204448 @default.
- W4366598368 hasConcept C555293320 @default.
- W4366598368 hasConcept C71924100 @default.
- W4366598368 hasConcept C89623803 @default.
- W4366598368 hasConceptScore W4366598368C126322002 @default.
- W4366598368 hasConceptScore W4366598368C134018914 @default.
- W4366598368 hasConceptScore W4366598368C142724271 @default.
- W4366598368 hasConceptScore W4366598368C168563851 @default.
- W4366598368 hasConceptScore W4366598368C197934379 @default.
- W4366598368 hasConceptScore W4366598368C204787440 @default.
- W4366598368 hasConceptScore W4366598368C27081682 @default.
- W4366598368 hasConceptScore W4366598368C2779134260 @default.
- W4366598368 hasConceptScore W4366598368C3008058167 @default.
- W4366598368 hasConceptScore W4366598368C524204448 @default.
- W4366598368 hasConceptScore W4366598368C555293320 @default.
- W4366598368 hasConceptScore W4366598368C71924100 @default.
- W4366598368 hasConceptScore W4366598368C89623803 @default.
- W4366598368 hasFunder F4320323291 @default.
- W4366598368 hasIssue "8" @default.
- W4366598368 hasLocation W43665983681 @default.
- W4366598368 hasLocation W43665983682 @default.
- W4366598368 hasLocation W43665983683 @default.