FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366602022> ?p ?o ?g. }

• W4366602022 endingPage "2898" @default.
• W4366602022 startingPage "2877" @default.
• W4366602022 abstract "The impact of age on exercise pressor responses is equivocal, likely because of sex-specific neuro-cardiovascular changes with age. However, assessments of the interactive effects of age and sex on muscle sympathetic nerve activity (MSNA) responses to exercise are lacking. We tested the hypothesis that older females would exhibit exaggerated increases in blood pressure (BP) and MSNA discharge patterns during handgrip exercise compared with similarly aged males and young adults. Twenty-five young (25 (2) years; mean (SD)) males (YM; n = 12) and females (YF; n = 13) and 23 older (71 (5) years) males (OM; n = 11) and females (OF; n = 12) underwent assessments of BP, total peripheral resistance (TPR; Modelflow) and MSNA action potential (AP) discharge patterns (microneurography) during incremental rhythmic handgrip exercise and post-exercise circulatory occlusion (PECO). OM demonstrated larger ∆BP and ∆TPR from baseline than YM (both P < 0.001) despite smaller increases in ∆APs/burst (OM: 0.4 (3) vs. YM: 5 (3) spikes/burst, P < 0.001) and ∆AP clusters/burst (OM: 0.1 (1) vs. YM: 1.8 (1) clusters/burst, P < 0.001) during exercise. Testosterone was lower in OM than YM (P < 0.001) and was inversely related to ∆BP but positively related to ∆AP clusters/burst in males (both P = 0.03). Conversely, YF and OF demonstrated similar ∆BP and ∆AP discharge during exercise (range: P = 0.75-0.96). Age and sex did not impact haemodynamics or AP discharge during PECO (range: P = 0.08-0.94). Altogether, age-related changes in neuro-cardiovascular reactivity exist in males but not females during fatiguing exercise and seem to be related to testosterone. This sex-specific impact of age underscores the importance of considering biological sex when assessing age-related changes in neuro-cardiovascular control during exercise. KEY POINTS: Older males have the largest increase in blood pressure despite having the smallest increases in sympathetic vasomotor outflow during rhythmic handgrip exercise. Young males demonstrate greater increases in sympathetic action potential (AP) discharge compared with young females during rhythmic handgrip exercise. Older adults (regardless of sex) demonstrate smaller increases in muscle sympathetic nerve activity (MSNA) burst amplitude and total AP clusters compared with young adults during exercise, as well as smaller increases in integrated MSNA burst frequency, incidence and total MSNA activity during post-exercise circulatory occlusion (i.e. independent effect of age). Males, but not females (regardless of age), reflexively modify AP conduction velocity during exercise. Our results indicate that age and sex independently and interactively impact the neural and cardiovascular homeostatic adjustments to fatiguing small muscle mass exercise." @default.
• W4366602022 created "2023-04-23" @default.
• W4366602022 creator A5000651912 @default.
• W4366602022 creator A5006811250 @default.
• W4366602022 creator A5011395175 @default.
• W4366602022 creator A5015020165 @default.
• W4366602022 creator A5031112710 @default.
• W4366602022 creator A5043946200 @default.
• W4366602022 creator A5045984858 @default.
• W4366602022 creator A5057727993 @default.
• W4366602022 creator A5086962507 @default.
• W4366602022 date "2023-05-05" @default.
• W4366602022 modified "2023-10-11" @default.
• W4366602022 title "The interactive effects of age and sex on the neuro‐cardiovascular responses during fatiguing rhythmic handgrip exercise" @default.
• W4366602022 cites W143558105 @default.
• W4366602022 cites W1532021133 @default.
• W4366602022 cites W1554226845 @default.
• W4366602022 cites W1565996663 @default.
• W4366602022 cites W1702568920 @default.
• W4366602022 cites W1764638724 @default.
• W4366602022 cites W1794386847 @default.
• W4366602022 cites W1891319178 @default.
• W4366602022 cites W1896419431 @default.
• W4366602022 cites W1976960842 @default.
• W4366602022 cites W1982366717 @default.
• W4366602022 cites W1992715824 @default.
• W4366602022 cites W2004008756 @default.
• W4366602022 cites W2018205683 @default.
• W4366602022 cites W2046473216 @default.
• W4366602022 cites W2048556283 @default.
• W4366602022 cites W2049064302 @default.
• W4366602022 cites W2049972637 @default.
• W4366602022 cites W2052741645 @default.
• W4366602022 cites W2055230461 @default.
• W4366602022 cites W2064620945 @default.
• W4366602022 cites W2065585544 @default.
• W4366602022 cites W2079512683 @default.
• W4366602022 cites W2081544739 @default.
• W4366602022 cites W2083773011 @default.
• W4366602022 cites W2085512316 @default.
• W4366602022 cites W2094346162 @default.
• W4366602022 cites W2095971269 @default.
• W4366602022 cites W2098247759 @default.
• W4366602022 cites W2108128316 @default.
• W4366602022 cites W2108939805 @default.
• W4366602022 cites W2111951523 @default.
• W4366602022 cites W2112026707 @default.
• W4366602022 cites W2120653792 @default.
• W4366602022 cites W2125043125 @default.
• W4366602022 cites W2131742399 @default.
• W4366602022 cites W2134822922 @default.
• W4366602022 cites W2139729561 @default.
• W4366602022 cites W2140240484 @default.
• W4366602022 cites W2141249406 @default.
• W4366602022 cites W2147062134 @default.
• W4366602022 cites W2150819010 @default.
• W4366602022 cites W2156429510 @default.
• W4366602022 cites W2160677706 @default.
• W4366602022 cites W2164514754 @default.
• W4366602022 cites W2167933596 @default.
• W4366602022 cites W2169125742 @default.
• W4366602022 cites W2181663293 @default.
• W4366602022 cites W2193766064 @default.
• W4366602022 cites W2272262799 @default.
• W4366602022 cites W2339871793 @default.
• W4366602022 cites W2511175036 @default.
• W4366602022 cites W2540601554 @default.
• W4366602022 cites W2600900489 @default.
• W4366602022 cites W2763067220 @default.
• W4366602022 cites W2786609060 @default.
• W4366602022 cites W3014099170 @default.
• W4366602022 cites W3043853435 @default.
• W4366602022 cites W3048921858 @default.
• W4366602022 cites W3138002401 @default.
• W4366602022 cites W3203310082 @default.
• W4366602022 cites W4210470783 @default.
• W4366602022 cites W4214757721 @default.
• W4366602022 cites W4226374452 @default.
• W4366602022 cites W4237546140 @default.
• W4366602022 cites W4283315091 @default.
• W4366602022 cites W4296220344 @default.
• W4366602022 cites W61977801 @default.
• W4366602022 doi "https://doi.org/10.1113/jp284517" @default.
• W4366602022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37083007" @default.
• W4366602022 hasPublicationYear "2023" @default.
• W4366602022 type Work @default.
• W4366602022 citedByCount "3" @default.
• W4366602022 countsByYear W43666020222023 @default.
• W4366602022 crossrefType "journal-article" @default.
• W4366602022 hasAuthorship W4366602022A5000651912 @default.
• W4366602022 hasAuthorship W4366602022A5006811250 @default.
• W4366602022 hasAuthorship W4366602022A5011395175 @default.
• W4366602022 hasAuthorship W4366602022A5015020165 @default.
• W4366602022 hasAuthorship W4366602022A5031112710 @default.
• W4366602022 hasAuthorship W4366602022A5043946200 @default.
• W4366602022 hasAuthorship W4366602022A5045984858 @default.
• W4366602022 hasAuthorship W4366602022A5057727993 @default.
• W4366602022 hasAuthorship W4366602022A5086962507 @default.

• next