Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366602110> ?p ?o ?g. }
- W4366602110 endingPage "e0284135" @default.
- W4366602110 startingPage "e0284135" @default.
- W4366602110 abstract "We have developed a cell-based outer vocal fold replacement (COVR) as a potential therapy to improve voice quality after vocal fold (VF) injury, radiation, or tumor resection. The COVR consists of multipotent human adipose-derived stem cells (hASC) embedded within a three-dimensional fibrin scaffold that resembles vocal fold epithelium and lamina propria layers. Previous work has shown improved wound healing in rabbit studies. In this pilot study in pigs, we sought to develop methods for large animal implantation and phonatory assessment. Feasibility, safety, and structural and functional outcomes of the COVR implant are described. Of eight pigs studied, six animals underwent COVR implantation with harvest between 2 weeks and 6 months. Recovery of laryngeal tissue structure was assessed by vibratory and histologic analyses. Recovery of voice function was assessed by investigating acoustic parameters that were derived specifically for pigs. Results showed improved lamina propria qualities relative to an injured control animal at 6 months. Acoustic parameters reflected voice worsening immediately after surgery as expected; acoustics displayed clear voice recovery in the animal followed for 6 months after COVR. These methods form the basis for a larger-scale long-term pre-clinical safety and efficacy study." @default.
- W4366602110 created "2023-04-23" @default.
- W4366602110 creator A5001835994 @default.
- W4366602110 creator A5006063847 @default.
- W4366602110 creator A5022091778 @default.
- W4366602110 creator A5024048702 @default.
- W4366602110 creator A5041749466 @default.
- W4366602110 creator A5052467830 @default.
- W4366602110 creator A5065465370 @default.
- W4366602110 creator A5072634898 @default.
- W4366602110 creator A5082961597 @default.
- W4366602110 date "2023-04-21" @default.
- W4366602110 modified "2023-09-25" @default.
- W4366602110 title "Tissue-engineered vocal fold replacement in swine: Methods for functional and structural analysis" @default.
- W4366602110 cites W1531237901 @default.
- W4366602110 cites W1596515083 @default.
- W4366602110 cites W1759016301 @default.
- W4366602110 cites W1965257340 @default.
- W4366602110 cites W1969729382 @default.
- W4366602110 cites W1977057781 @default.
- W4366602110 cites W1986112602 @default.
- W4366602110 cites W1991293579 @default.
- W4366602110 cites W1995245587 @default.
- W4366602110 cites W2000673271 @default.
- W4366602110 cites W2006633963 @default.
- W4366602110 cites W2026809681 @default.
- W4366602110 cites W2030715889 @default.
- W4366602110 cites W2049659540 @default.
- W4366602110 cites W2050600834 @default.
- W4366602110 cites W2051845816 @default.
- W4366602110 cites W2054606732 @default.
- W4366602110 cites W2065062519 @default.
- W4366602110 cites W2090092183 @default.
- W4366602110 cites W2097360117 @default.
- W4366602110 cites W2134190445 @default.
- W4366602110 cites W2162737850 @default.
- W4366602110 cites W2165431515 @default.
- W4366602110 cites W2172204670 @default.
- W4366602110 cites W2173497140 @default.
- W4366602110 cites W2178709787 @default.
- W4366602110 cites W2193538485 @default.
- W4366602110 cites W2277856483 @default.
- W4366602110 cites W2300856748 @default.
- W4366602110 cites W2469106799 @default.
- W4366602110 cites W2479215566 @default.
- W4366602110 cites W2508331757 @default.
- W4366602110 cites W2509730992 @default.
- W4366602110 cites W2520103202 @default.
- W4366602110 cites W2605187236 @default.
- W4366602110 cites W2631421257 @default.
- W4366602110 cites W2742230282 @default.
- W4366602110 cites W2766777704 @default.
- W4366602110 cites W2774137260 @default.
- W4366602110 cites W2897543096 @default.
- W4366602110 cites W2921586423 @default.
- W4366602110 cites W2943378944 @default.
- W4366602110 cites W2968810602 @default.
- W4366602110 cites W3007098717 @default.
- W4366602110 cites W3012769832 @default.
- W4366602110 cites W3160751184 @default.
- W4366602110 cites W4285686269 @default.
- W4366602110 cites W4297238391 @default.
- W4366602110 cites W4366602110 @default.
- W4366602110 cites W3107234937 @default.
- W4366602110 doi "https://doi.org/10.1371/journal.pone.0284135" @default.
- W4366602110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37083641" @default.
- W4366602110 hasPublicationYear "2023" @default.
- W4366602110 type Work @default.
- W4366602110 citedByCount "1" @default.
- W4366602110 countsByYear W43666021102023 @default.
- W4366602110 crossrefType "journal-article" @default.
- W4366602110 hasAuthorship W4366602110A5001835994 @default.
- W4366602110 hasAuthorship W4366602110A5006063847 @default.
- W4366602110 hasAuthorship W4366602110A5022091778 @default.
- W4366602110 hasAuthorship W4366602110A5024048702 @default.
- W4366602110 hasAuthorship W4366602110A5041749466 @default.
- W4366602110 hasAuthorship W4366602110A5052467830 @default.
- W4366602110 hasAuthorship W4366602110A5065465370 @default.
- W4366602110 hasAuthorship W4366602110A5072634898 @default.
- W4366602110 hasAuthorship W4366602110A5082961597 @default.
- W4366602110 hasBestOaLocation W43666021101 @default.
- W4366602110 hasConcept C141071460 @default.
- W4366602110 hasConcept C142724271 @default.
- W4366602110 hasConcept C173988693 @default.
- W4366602110 hasConcept C2777310793 @default.
- W4366602110 hasConcept C2780269544 @default.
- W4366602110 hasConcept C2780336059 @default.
- W4366602110 hasConcept C2780474809 @default.
- W4366602110 hasConcept C3019592751 @default.
- W4366602110 hasConcept C529295009 @default.
- W4366602110 hasConcept C548259974 @default.
- W4366602110 hasConcept C71924100 @default.
- W4366602110 hasConceptScore W4366602110C141071460 @default.
- W4366602110 hasConceptScore W4366602110C142724271 @default.
- W4366602110 hasConceptScore W4366602110C173988693 @default.
- W4366602110 hasConceptScore W4366602110C2777310793 @default.
- W4366602110 hasConceptScore W4366602110C2780269544 @default.
- W4366602110 hasConceptScore W4366602110C2780336059 @default.