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• W4366602562 abstract "The highly utilized KC model has a reported lethality rate of about 30%, which has been attributed to pancreas cancer. However, a competing cause of lethality in KC mice is due to the activation of mutant-Kras gene (KrasG12D/+) in the multipotent progenitor cells (MPP), and subsequent development of Kras-mutant T-cell acute lymphoblastic leukemia (T-ALL). Overall, 20% (5/25) of KC mice developed T-ALL by 9 months of age. Transplantation of pooled bone marrow from KC mice into CD45 congenic mice caused T-ALL in 100% of recipient mice, confirming that mutant-Kras expression in the hematologic compartment is driving the development of T-ALL in the KC mouse model. These results are an essential consideration for investigators using this model. Further, the lower penetrance of T-ALL in KC mice (versus existing leukemia models) suggests this model could be considered as an alternative research model to evaluate onset and factors that exacerbate the development of T-ALL." @default.
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• W4366602562 date "2023-04-20" @default.
• W4366602562 modified "2023-09-27" @default.
• W4366602562 title "Pdx1 expression in hematopoietic cells activates <i>Kras</i>-mutation to drive leukemia in KC (<i>Pdx1-Cre; LSL-Kras^G12D/+</i>) mice" @default.
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• W4366602562 doi "https://doi.org/10.1080/10428194.2023.2202788" @default.
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