Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366602826> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W4366602826 endingPage "331" @default.
- W4366602826 startingPage "327" @default.
- W4366602826 abstract "β-thalassemia trait is usually diagnosed by raised hemoglobin A2 (HbA2). The presence of megaloblastic anemia can cause an increase in HbA2 and create a diagnostic dilemma. Here, we have analyzed the effect of vitamin B12 and folic acid supplementation on HbA2 and diagnosis of β-thalassemia trait in cases of megaloblastic anemia with raised HbA2.Cases of megaloblastic anemia with raised HbA2 on high-performance liquid chromatography (HPLC) were supplemented with vitamin B12 and folic acid. Post-treatment evaluation was done after 2 months. Cases showing adequate hematological response were subjected to statistical analysis. Based on post-treatment HbA2 value, the cases were diagnosed as normal, borderline raised HbA2, or β-thalassemia trait. Pre- and post-treatment values of red cell parameters and HbA2 were analyzed.There was a significant decrease in HbA2 value after vitamin B12 and folic acid supplementation. The diagnosis was changed in 70.97% of the cases after treatment. The chance of inconclusive diagnosis was decreased from more than 50% to less than 10%. Pre-treatment mean corpuscular volume (MCV) and HbA2% showed a significant difference between the thalassemic and normal groups.Megaloblastic anemia can lead to false-positive diagnosis of β-thalassemia trait on HPLC. Repeat HPLC should be done after adequate supplementation of vitamin B12 and folic acid in cases of megaloblastic anemia with raised HbA2. Red cell parameters are not helpful to suspect β-thalassemia trait in presence of megaloblastic anemia. However, HbA2% on HPLC can be a useful parameter to suspect or exclude β-thalassemia trait in cases of megaloblastic anemia." @default.
- W4366602826 created "2023-04-23" @default.
- W4366602826 creator A5006489043 @default.
- W4366602826 creator A5009717230 @default.
- W4366602826 creator A5011929476 @default.
- W4366602826 creator A5032758895 @default.
- W4366602826 date "2023-04-20" @default.
- W4366602826 modified "2023-10-18" @default.
- W4366602826 title "Effect of megaloblastic anemia on hemoglobin A2 and diagnosis of β-thalassemia trait." @default.
- W4366602826 doi "https://doi.org/10.4103/ijpm.ijpm_233_21" @default.
- W4366602826 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37077076" @default.
- W4366602826 hasPublicationYear "2023" @default.
- W4366602826 type Work @default.
- W4366602826 citedByCount "0" @default.
- W4366602826 crossrefType "journal-article" @default.
- W4366602826 hasAuthorship W4366602826A5006489043 @default.
- W4366602826 hasAuthorship W4366602826A5009717230 @default.
- W4366602826 hasAuthorship W4366602826A5011929476 @default.
- W4366602826 hasAuthorship W4366602826A5032758895 @default.
- W4366602826 hasConcept C126322002 @default.
- W4366602826 hasConcept C2777216359 @default.
- W4366602826 hasConcept C2777799968 @default.
- W4366602826 hasConcept C2778248108 @default.
- W4366602826 hasConcept C2778917026 @default.
- W4366602826 hasConcept C2779405478 @default.
- W4366602826 hasConcept C2779750884 @default.
- W4366602826 hasConcept C2781058662 @default.
- W4366602826 hasConcept C42407357 @default.
- W4366602826 hasConcept C71924100 @default.
- W4366602826 hasConcept C90924648 @default.
- W4366602826 hasConceptScore W4366602826C126322002 @default.
- W4366602826 hasConceptScore W4366602826C2777216359 @default.
- W4366602826 hasConceptScore W4366602826C2777799968 @default.
- W4366602826 hasConceptScore W4366602826C2778248108 @default.
- W4366602826 hasConceptScore W4366602826C2778917026 @default.
- W4366602826 hasConceptScore W4366602826C2779405478 @default.
- W4366602826 hasConceptScore W4366602826C2779750884 @default.
- W4366602826 hasConceptScore W4366602826C2781058662 @default.
- W4366602826 hasConceptScore W4366602826C42407357 @default.
- W4366602826 hasConceptScore W4366602826C71924100 @default.
- W4366602826 hasConceptScore W4366602826C90924648 @default.
- W4366602826 hasIssue "2" @default.
- W4366602826 hasLocation W43666028261 @default.
- W4366602826 hasOpenAccess W4366602826 @default.
- W4366602826 hasPrimaryLocation W43666028261 @default.
- W4366602826 hasRelatedWork W1495826706 @default.
- W4366602826 hasRelatedWork W179797958 @default.
- W4366602826 hasRelatedWork W2148414105 @default.
- W4366602826 hasRelatedWork W2418251975 @default.
- W4366602826 hasRelatedWork W2750911348 @default.
- W4366602826 hasRelatedWork W3027127089 @default.
- W4366602826 hasRelatedWork W3032004755 @default.
- W4366602826 hasRelatedWork W4233616290 @default.
- W4366602826 hasRelatedWork W4285212355 @default.
- W4366602826 hasRelatedWork W4366602826 @default.
- W4366602826 hasVolume "66" @default.
- W4366602826 isParatext "false" @default.
- W4366602826 isRetracted "false" @default.
- W4366602826 workType "article" @default.