FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366603044> ?p ?o ?g. }

• W4366603044 endingPage "3205" @default.
• W4366603044 startingPage "3192" @default.
• W4366603044 abstract "Amyloid-β (Aβ) is hypothesized to facilitate the spread of tau pathology beyond the medial temporal lobe. However, there is evidence that, independently of Aβ, age-related tau pathology might be present outside of the medial temporal lobe. We therefore aimed to study age-related Aβ-independent tau deposition outside the medial temporal lobe in two large cohorts and to investigate potential downstream effects of this on cognition and structural measures. We included 545 cognitively unimpaired adults (40-92 years) from the BioFINDER-2 study (in vivo) and 639 (64-108 years) from the Rush Alzheimer's Disease Center cohorts (ex vivo). 18F-RO948- and 18F-flutemetamol-PET standardized uptake value ratios were calculated for regional tau and global/regional Aβ in vivo. Immunohistochemistry was used to estimate Aβ load and tangle density ex vivo. In vivo medial temporal lobe volumes (subiculum, cornu ammonis 1) and cortical thickness (entorhinal cortex, Brodmann area 35) were obtained using Automated Segmentation for Hippocampal Subfields packages. Thickness of early and late neocortical Alzheimer's disease regions was determined using FreeSurfer. Global cognition and episodic memory were estimated to quantify cognitive functioning. In vivo age-related tau deposition was observed in the medial temporal lobe and in frontal and parietal cortical regions, which was statistically significant when adjusting for Aβ. This was also observed in individuals with low Aβ load. Tau deposition was negatively associated with cortical volumes and thickness in temporal and parietal regions independently of Aβ. The associations between age and cortical volume or thickness were partially mediated via tau in regions with early Alzheimer's disease pathology, i.e. early tau and/or Aβ pathology (subiculum/Brodmann area 35/precuneus/posterior cingulate). Finally, the associations between age and cognition were partially mediated via tau in Brodmann area 35, even when including Aβ-PET as covariate. Results were validated in the ex vivo cohort showing age-related and Aβ-independent increases in tau aggregates in and outside the medial temporal lobe. Ex vivo age-cognition associations were mediated by medial and inferior temporal tau tangle density, while correcting for Aβ density. Taken together, our study provides support for primary age-related tauopathy even outside the medial temporal lobe in vivo and ex vivo, with downstream effects on structure and cognition. These results have implications for our understanding of the spreading of tau outside the medial temporal lobe, also in the context of Alzheimer's disease. Moreover, this study suggests the potential utility of tau-targeting treatments in primary age-related tauopathy, likely already in preclinical stages in individuals with low Aβ pathology." @default.
• W4366603044 created "2023-04-23" @default.
• W4366603044 creator A5014075642 @default.
• W4366603044 creator A5014524757 @default.
• W4366603044 creator A5022605809 @default.
• W4366603044 creator A5023509155 @default.
• W4366603044 creator A5023889784 @default.
• W4366603044 creator A5024645775 @default.
• W4366603044 creator A5026996448 @default.
• W4366603044 creator A5031901743 @default.
• W4366603044 creator A5035346809 @default.
• W4366603044 creator A5043568262 @default.
• W4366603044 creator A5045465497 @default.
• W4366603044 creator A5045832365 @default.
• W4366603044 creator A5049277633 @default.
• W4366603044 creator A5053836176 @default.
• W4366603044 creator A5057342287 @default.
• W4366603044 creator A5059352708 @default.
• W4366603044 creator A5068219858 @default.
• W4366603044 creator A5073478649 @default.
• W4366603044 creator A5082771552 @default.
• W4366603044 date "2023-04-21" @default.
• W4366603044 modified "2023-10-16" @default.
• W4366603044 title "Age-related and amyloid-beta-independent tau deposition and its downstream effects" @default.
• W4366603044 cites W1513618424 @default.
• W4366603044 cites W1548995643 @default.
• W4366603044 cites W1739514309 @default.
• W4366603044 cites W1847168837 @default.
• W4366603044 cites W1912212332 @default.
• W4366603044 cites W1913957972 @default.
• W4366603044 cites W1967823816 @default.
• W4366603044 cites W1971032265 @default.
• W4366603044 cites W2008854521 @default.
• W4366603044 cites W2026017720 @default.
• W4366603044 cites W2032221178 @default.
• W4366603044 cites W2052742260 @default.
• W4366603044 cites W2058161128 @default.
• W4366603044 cites W2077119043 @default.
• W4366603044 cites W2083213758 @default.
• W4366603044 cites W2103440561 @default.
• W4366603044 cites W2107141858 @default.
• W4366603044 cites W2140947257 @default.
• W4366603044 cites W2143461767 @default.
• W4366603044 cites W2146729934 @default.
• W4366603044 cites W2148080316 @default.
• W4366603044 cites W2153549946 @default.
• W4366603044 cites W2167311298 @default.
• W4366603044 cites W2168080333 @default.
• W4366603044 cites W2171385920 @default.
• W4366603044 cites W2219014187 @default.
• W4366603044 cites W2290598353 @default.
• W4366603044 cites W2302528231 @default.
• W4366603044 cites W2329336071 @default.
• W4366603044 cites W2498631646 @default.
• W4366603044 cites W2556852663 @default.
• W4366603044 cites W2584431885 @default.
• W4366603044 cites W2596999834 @default.
• W4366603044 cites W2607259606 @default.
• W4366603044 cites W2620512676 @default.
• W4366603044 cites W2765181675 @default.
• W4366603044 cites W2766125374 @default.
• W4366603044 cites W2767453481 @default.
• W4366603044 cites W2774369241 @default.
• W4366603044 cites W2775311168 @default.
• W4366603044 cites W2789976306 @default.
• W4366603044 cites W2790798430 @default.
• W4366603044 cites W2791135917 @default.
• W4366603044 cites W2798054687 @default.
• W4366603044 cites W2799729840 @default.
• W4366603044 cites W2809330972 @default.
• W4366603044 cites W2901821003 @default.
• W4366603044 cites W2942818360 @default.
• W4366603044 cites W2945475774 @default.
• W4366603044 cites W2947200125 @default.
• W4366603044 cites W2953216263 @default.
• W4366603044 cites W2962893048 @default.
• W4366603044 cites W2971637931 @default.
• W4366603044 cites W2971871890 @default.
• W4366603044 cites W2981103034 @default.
• W4366603044 cites W2989855650 @default.
• W4366603044 cites W2996573401 @default.
• W4366603044 cites W2996576044 @default.
• W4366603044 cites W3018098624 @default.
• W4366603044 cites W3021135759 @default.
• W4366603044 cites W3030476832 @default.
• W4366603044 cites W3042582463 @default.
• W4366603044 cites W3045997188 @default.
• W4366603044 cites W3048109944 @default.
• W4366603044 cites W3084090497 @default.
• W4366603044 cites W3091188840 @default.
• W4366603044 cites W3099277996 @default.
• W4366603044 cites W3111062478 @default.
• W4366603044 cites W3122375100 @default.
• W4366603044 cites W3139143010 @default.
• W4366603044 cites W3145486919 @default.
• W4366603044 cites W3164390524 @default.
• W4366603044 cites W3203244102 @default.
• W4366603044 cites W3207243873 @default.

• next