FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366603469> ?p ?o ?g. }

• W4366603469 abstract "Abstract Motivation As an important group of proteins discovered in phages, anti-CRISPR inhibits the activity of the immune system of bacteria (i.e. CRISPR-Cas), offering promise for gene editing and phage therapy. However, the prediction and discovery of anti-CRISPR are challenging due to their high variability and fast evolution. Existing biological studies rely on known CRISPR and anti-CRISPR pairs, which may not be practical considering the huge number. Computational methods struggle with prediction performance. To address these issues, we propose a novel deep neural network for anti-CRISPR analysis (AcrNET), which achieves significant performance. Results On both the cross-fold and cross-dataset validation, our method outperforms the state-of-the-art methods. Notably, AcrNET improves the prediction performance by at least 15% regarding the F1 score for the cross-dataset test problem comparing with state-of-art Deep Learning method. Moreover, AcrNET is the first computational method to predict the detailed anti-CRISPR classes, which may help illustrate the anti-CRISPR mechanism. Taking advantage of a Transformer protein language model ESM-1b, which was pre-trained on 250 million protein sequences, AcrNET overcomes the data scarcity problem. Extensive experiments and analysis suggest that the Transformer model feature, evolutionary feature, and local structure feature complement each other, which indicates the critical properties of anti-CRISPR proteins. AlphaFold prediction, further motif analysis, and docking experiments further demonstrate that AcrNET can capture the evolutionarily conserved pattern and the interaction between anti-CRISPR and the target implicitly. Availability and implementation Web server: https://proj.cse.cuhk.edu.hk/aihlab/AcrNET/. Training code and pre-trained model are available at." @default.
• W4366603469 created "2023-04-23" @default.
• W4366603469 creator A5002621017 @default.
• W4366603469 creator A5018102503 @default.
• W4366603469 creator A5044326831 @default.
• W4366603469 creator A5049525828 @default.
• W4366603469 creator A5056334408 @default.
• W4366603469 creator A5065565580 @default.
• W4366603469 creator A5070141978 @default.
• W4366603469 creator A5078001917 @default.
• W4366603469 creator A5078483754 @default.
• W4366603469 creator A5087040829 @default.
• W4366603469 date "2023-04-21" @default.
• W4366603469 modified "2023-10-16" @default.
• W4366603469 title "AcrNET: predicting anti-CRISPR with deep learning" @default.
• W4366603469 cites W1592870802 @default.
• W4366603469 cites W1899503782 @default.
• W4366603469 cites W1913949000 @default.
• W4366603469 cites W1981264193 @default.
• W4366603469 cites W2008708467 @default.
• W4366603469 cites W2030793934 @default.
• W4366603469 cites W2043083543 @default.
• W4366603469 cites W2054394841 @default.
• W4366603469 cites W2068361619 @default.
• W4366603469 cites W2102461176 @default.
• W4366603469 cites W2108581046 @default.
• W4366603469 cites W2115434912 @default.
• W4366603469 cites W2119331235 @default.
• W4366603469 cites W2129279466 @default.
• W4366603469 cites W2140992384 @default.
• W4366603469 cites W2430331709 @default.
• W4366603469 cites W2561826764 @default.
• W4366603469 cites W2562674913 @default.
• W4366603469 cites W2564226239 @default.
• W4366603469 cites W2572080171 @default.
• W4366603469 cites W2612935389 @default.
• W4366603469 cites W2615136515 @default.
• W4366603469 cites W2623277795 @default.
• W4366603469 cites W2744099942 @default.
• W4366603469 cites W2757079914 @default.
• W4366603469 cites W2766352633 @default.
• W4366603469 cites W2766874121 @default.
• W4366603469 cites W2890107400 @default.
• W4366603469 cites W2908663744 @default.
• W4366603469 cites W3011910186 @default.
• W4366603469 cites W3015370321 @default.
• W4366603469 cites W3015438624 @default.
• W4366603469 cites W3024100655 @default.
• W4366603469 cites W3029055906 @default.
• W4366603469 cites W3041180919 @default.
• W4366603469 cites W3045990256 @default.
• W4366603469 cites W3097237310 @default.
• W4366603469 cites W3146944767 @default.
• W4366603469 cites W3158075195 @default.
• W4366603469 cites W3174738524 @default.
• W4366603469 cites W4211083314 @default.
• W4366603469 cites W4281963872 @default.
• W4366603469 doi "https://doi.org/10.1093/bioinformatics/btad259" @default.
• W4366603469 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37084259" @default.
• W4366603469 hasPublicationYear "2023" @default.
• W4366603469 type Work @default.
• W4366603469 citedByCount "0" @default.
• W4366603469 crossrefType "journal-article" @default.
• W4366603469 hasAuthorship W4366603469A5002621017 @default.
• W4366603469 hasAuthorship W4366603469A5018102503 @default.
• W4366603469 hasAuthorship W4366603469A5044326831 @default.
• W4366603469 hasAuthorship W4366603469A5049525828 @default.
• W4366603469 hasAuthorship W4366603469A5056334408 @default.
• W4366603469 hasAuthorship W4366603469A5065565580 @default.
• W4366603469 hasAuthorship W4366603469A5070141978 @default.
• W4366603469 hasAuthorship W4366603469A5078001917 @default.
• W4366603469 hasAuthorship W4366603469A5078483754 @default.
• W4366603469 hasAuthorship W4366603469A5087040829 @default.
• W4366603469 hasBestOaLocation W43666034691 @default.
• W4366603469 hasConcept C104317684 @default.
• W4366603469 hasConcept C108583219 @default.
• W4366603469 hasConcept C119599485 @default.
• W4366603469 hasConcept C119857082 @default.
• W4366603469 hasConcept C127413603 @default.
• W4366603469 hasConcept C154945302 @default.
• W4366603469 hasConcept C165801399 @default.
• W4366603469 hasConcept C41008148 @default.
• W4366603469 hasConcept C54355233 @default.
• W4366603469 hasConcept C66322947 @default.
• W4366603469 hasConcept C70721500 @default.
• W4366603469 hasConcept C86803240 @default.
• W4366603469 hasConcept C98108389 @default.
• W4366603469 hasConceptScore W4366603469C104317684 @default.
• W4366603469 hasConceptScore W4366603469C108583219 @default.
• W4366603469 hasConceptScore W4366603469C119599485 @default.
• W4366603469 hasConceptScore W4366603469C119857082 @default.
• W4366603469 hasConceptScore W4366603469C127413603 @default.
• W4366603469 hasConceptScore W4366603469C154945302 @default.
• W4366603469 hasConceptScore W4366603469C165801399 @default.
• W4366603469 hasConceptScore W4366603469C41008148 @default.
• W4366603469 hasConceptScore W4366603469C54355233 @default.
• W4366603469 hasConceptScore W4366603469C66322947 @default.
• W4366603469 hasConceptScore W4366603469C70721500 @default.
• W4366603469 hasConceptScore W4366603469C86803240 @default.
• W4366603469 hasConceptScore W4366603469C98108389 @default.

• next