Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366603709> ?p ?o ?g. }
- W4366603709 abstract "Abstract Small interfering RNA (siRNA) holds immense promise for suppressing gene expression and treating various life‐threatening diseases, including cancer. However, efficient delivery and lysosomal escape remain critical challenges that hinder the therapeutic effectiveness of siRNA. Herein, cationic photosensitizer (NB‐Br) is grafted onto polo‐like kinase 1 (PLK1) siRNA to form an amphiphilic siRNA‐photosensitizer conjugate (siPLK1‐NB), which can self‐assemble into nanoparticles (siPLK1‐NB NPs) via electrostatic attraction. Notably, siPLK1‐NB NPs exhibit rapid and efficient cell endocytosis, as well as outstanding tumor‐targeting property in multiple tumor‐bearing mice models. When siPLK1‐NB NPs are located inside tumor cell lysosomes, the generated reactive oxygen species (ROS) after photoactivation can disrupt the lysosome membrane structure and facilitate siRNA escape from lysosomes. Under light irradiation, siPLK1‐NB NPs can downregulate PLK1 expression and induce photodynamic killing, effectively inhibiting tumor cell growth both in vitro and in vivo. Consequently, this study provides a novel design strategy for carrier‐free siRNA delivery systems. As far as it is known, this is the first report of a carrier‐free siRNA delivery system based on electrostatic attraction." @default.
- W4366603709 created "2023-04-23" @default.
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- W4366603709 date "2023-06-09" @default.
- W4366603709 modified "2023-10-14" @default.
- W4366603709 title "Electrostatic Attractive Self‐Delivery of siRNA and Light‐Induced Self‐Escape for Synergistic Gene Therapy" @default.
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- W4366603709 doi "https://doi.org/10.1002/adma.202301409" @default.
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