FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366605721> ?p ?o ?g. }

• W4366605721 abstract "Orexins are hypothalamic neuropeptides associated with various neurophysiological activities such as sleep, arousal, and reward. However, there are few studies investigating the relationships between orexin receptors in the paraventricular nucleus and sexual behaviors.To explore the roles of orexin receptors in the paraventricular nucleus on sexual behaviors and uncover its potential mechanisms in males.Orexin A, orexin 1 receptor antagonist SB334867, and orexin 2 receptor antagonist TCS-OX2-29 were microinjected into the paraventricular nucleus to investigate the effects of orexin receptors on copulatory behavior testing of C57BL/6 mice. To explore if ejaculation could activate orexin 1 receptor-expressing neurons in the paraventricular nucleus, fluorescence immunohistochemical double staining was utilized. The levels of serum norepinephrine were measured and the lumbar sympathetic nerve activity was recorded to reflect the sympathetic nervous system activity. Moreover, the bulbospongiosus muscle-electromyogram was recorded and analyzed. To test whether perifornical/lateral hypothalamic area orexinergic neurons directly projected to the paraventricular nucleus, virus retrograde tracing technology was utilized.Orexin A significantly enhanced sexual performance by shortening the intromission and ejaculation latencies, and increasing the mount and intromission frequencies, while the opposite outcomes appeared with SB334867. However, TCS-OX2-29 had no significant effects on sexual behaviors. Moreover, orexin A increased lumbar sympathetic nerve activity and the levels of serum norepinephrine, while SB334867 decreased lumbar sympathetic nerve activity and norepinephrine, which caused a significant decrease in sympathetic nervous system outflow. Meanwhile, a robust increase in the bulbospongiosus muscle-electromyogram activity was identified after microinjecting orexin A. Furthermore, cFos immunopositive cells were increased and double stained with orexin 1 receptor-expressing neurons in the mating group. Additionally, the retrograde tracing results demonstrated that orexinergic neurons in the perifornical/lateral hypothalamic area directly projected to the paraventricular nucleus.Orexin 1 receptor in the paraventricular nucleus could influence the ejaculatory reflex via mediating the sympathetic nervous system activity, which might be of great importance in the treatment of premature ejaculation in the future." @default.
• W4366605721 created "2023-04-23" @default.
• W4366605721 creator A5014687439 @default.
• W4366605721 creator A5035698719 @default.
• W4366605721 creator A5042133353 @default.
• W4366605721 creator A5053217938 @default.
• W4366605721 creator A5062553515 @default.
• W4366605721 creator A5073779471 @default.
• W4366605721 creator A5075136340 @default.
• W4366605721 date "2023-05-04" @default.
• W4366605721 modified "2023-10-17" @default.
• W4366605721 title "Orexin receptors in paraventricular nucleus influence sexual behavior via regulating the sympathetic outflow in males" @default.
• W4366605721 cites W1164255036 @default.
• W4366605721 cites W121409461 @default.
• W4366605721 cites W1536911608 @default.
• W4366605721 cites W1627229807 @default.
• W4366605721 cites W1974447401 @default.
• W4366605721 cites W1980925491 @default.
• W4366605721 cites W1982792524 @default.
• W4366605721 cites W1986959306 @default.
• W4366605721 cites W1989818009 @default.
• W4366605721 cites W1993825767 @default.
• W4366605721 cites W1995221719 @default.
• W4366605721 cites W2004544166 @default.
• W4366605721 cites W2013049262 @default.
• W4366605721 cites W2027740042 @default.
• W4366605721 cites W2033944150 @default.
• W4366605721 cites W2034032465 @default.
• W4366605721 cites W2038063468 @default.
• W4366605721 cites W2039443858 @default.
• W4366605721 cites W2042070221 @default.
• W4366605721 cites W2046647573 @default.
• W4366605721 cites W2049087201 @default.
• W4366605721 cites W2056436647 @default.
• W4366605721 cites W2071755112 @default.
• W4366605721 cites W2072154498 @default.
• W4366605721 cites W2072867057 @default.
• W4366605721 cites W2075657426 @default.
• W4366605721 cites W2080322849 @default.
• W4366605721 cites W2091255351 @default.
• W4366605721 cites W2091943591 @default.
• W4366605721 cites W2094267963 @default.
• W4366605721 cites W2101800073 @default.
• W4366605721 cites W2124865173 @default.
• W4366605721 cites W2129340317 @default.
• W4366605721 cites W2129357751 @default.
• W4366605721 cites W2140500966 @default.
• W4366605721 cites W2143053439 @default.
• W4366605721 cites W2157949209 @default.
• W4366605721 cites W2160164449 @default.
• W4366605721 cites W2166873467 @default.
• W4366605721 cites W2191074630 @default.
• W4366605721 cites W2197464255 @default.
• W4366605721 cites W2386396427 @default.
• W4366605721 cites W2409360789 @default.
• W4366605721 cites W2727990065 @default.
• W4366605721 cites W2765655975 @default.
• W4366605721 cites W2772536478 @default.
• W4366605721 cites W2793437590 @default.
• W4366605721 cites W2806993167 @default.
• W4366605721 cites W2886396445 @default.
• W4366605721 cites W2891014150 @default.
• W4366605721 cites W2951989122 @default.
• W4366605721 cites W2956277877 @default.
• W4366605721 cites W3004494399 @default.
• W4366605721 cites W3006732065 @default.
• W4366605721 cites W3007787529 @default.
• W4366605721 cites W3044817976 @default.
• W4366605721 cites W3095154966 @default.
• W4366605721 cites W3096327674 @default.
• W4366605721 cites W4238738025 @default.
• W4366605721 cites W4293775061 @default.
• W4366605721 doi "https://doi.org/10.1111/andr.13444" @default.
• W4366605721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37084406" @default.
• W4366605721 hasPublicationYear "2023" @default.
• W4366605721 type Work @default.
• W4366605721 citedByCount "0" @default.
• W4366605721 crossrefType "journal-article" @default.
• W4366605721 hasAuthorship W4366605721A5014687439 @default.
• W4366605721 hasAuthorship W4366605721A5035698719 @default.
• W4366605721 hasAuthorship W4366605721A5042133353 @default.
• W4366605721 hasAuthorship W4366605721A5053217938 @default.
• W4366605721 hasAuthorship W4366605721A5062553515 @default.
• W4366605721 hasAuthorship W4366605721A5073779471 @default.
• W4366605721 hasAuthorship W4366605721A5075136340 @default.
• W4366605721 hasConcept C118303440 @default.
• W4366605721 hasConcept C126322002 @default.
• W4366605721 hasConcept C134018914 @default.
• W4366605721 hasConcept C169760540 @default.
• W4366605721 hasConcept C170493617 @default.
• W4366605721 hasConcept C185592680 @default.
• W4366605721 hasConcept C2776119998 @default.
• W4366605721 hasConcept C2776533406 @default.
• W4366605721 hasConcept C2777812360 @default.
• W4366605721 hasConcept C2778514916 @default.
• W4366605721 hasConcept C2779605129 @default.
• W4366605721 hasConcept C2779680196 @default.
• W4366605721 hasConcept C2780723820 @default.
• W4366605721 hasConcept C513476851 @default.
• W4366605721 hasConcept C71924100 @default.

• next