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- W4366605738 abstract "Abstract Retrotransposons are a class of transposable elements capable of self-replication and insertion into new genomic locations. Across species, the mobilization of retrotransposons in somatic cells has been suggested to contribute to the cell and tissue functional decline that occurs during aging. Retrotransposons are broadly expressed across cell types, and de novo insertions have been observed to correlate with tumorigenesis. However, the extent to which new retrotransposon insertions occur during normal aging and their effect on cellular and animal function remains understudied. Here, we use a single nucleus whole genome sequencing approach in Drosophila to directly test whether transposon insertions increase with age in somatic cells. Analyses of nuclei from thoraces and indirect flight muscles using a newly developed pipeline, Retrofind, revealed no significant increase in the number of transposon insertions with age. Despite this, reducing the expression of two different retrotransposons, 412 and Roo, extended lifespan, but did not alter indicators of health such as stress resistance. This suggests a key role for transposon expression and not insertion in regulating longevity. Transcriptomic analyses revealed similar changes to gene expression in 412 and Roo knockdown flies and highlighted changes to genes involved in proteolysis and immune function as potential contributors to the observed changes in longevity. Combined, our data show a clear link between retrotransposon expression and aging." @default.
- W4366605738 created "2023-04-23" @default.
- W4366605738 creator A5011198947 @default.
- W4366605738 creator A5012398734 @default.
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- W4366605738 creator A5024919125 @default.
- W4366605738 creator A5025870357 @default.
- W4366605738 creator A5031454252 @default.
- W4366605738 creator A5071847268 @default.
- W4366605738 creator A5084166143 @default.
- W4366605738 date "2023-04-21" @default.
- W4366605738 modified "2023-10-15" @default.
- W4366605738 title "Expression of retrotransposons contributes to aging in <i>Drosophila</i>" @default.
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