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- W4366606415 abstract "The knowledge that roughly 20% of survivors from an acute coronary syndrome (ACS) event experience a subsequent ischaemic cardiovascular event within 24 months with a 5-year mortality range between 19 and 22% highlights the importance of the lipid-lowering strategies in the secondary prevention after ACS. In this framework, statin treatment significantly improves clinical outcome after ACS. Within this remit, in the present review we critically discuss the use of statin and non-statin lipid-lowering approaches (ezetimibe, evolocumab, alirocumab, inclisiran, and bempedoic acid) in the early management of ACS patients. Relative to this latter aspect, the knowledge that circulating proprotein convertase subtilisin/kexin type 9 (PCSK9) levels are raised during ACS could be a generating hypothesis justifying the use of PCSK9 inhibitors in ACS. Thus, in a field fraught of uncertainty, the main barrier to the widespread prescription of non-statin agents (e.g. PCSK9 inhibitors) relates to their costs when compared with other lipid-lowering agents (e.g. statins and ezetimibe)." @default.
- W4366606415 created "2023-04-23" @default.
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- W4366606415 date "2023-04-01" @default.
- W4366606415 modified "2023-10-14" @default.
- W4366606415 title "Hypocholesterolaemic treatment in coronary unit: from statins to anti PCSK9 therapies and bempedoic acid" @default.
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- W4366606415 doi "https://doi.org/10.1093/eurheartjsupp/suad068" @default.
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