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- W4366606979 endingPage "2391.e9" @default.
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- W4366606979 abstract "Prime-boost regimens for COVID-19 vaccines elicit poor antibody responses against Omicron-based variants and employ frequent boosters to maintain antibody levels. We present a natural infection-mimicking technology that combines features of mRNA- and protein nanoparticle-based vaccines through encoding self-assembling enveloped virus-like particles (eVLPs). eVLP assembly is achieved by inserting an ESCRT- and ALIX-binding region (EABR) into the SARS-CoV-2 spike cytoplasmic tail, which recruits ESCRT proteins to induce eVLP budding from cells. Purified spike-EABR eVLPs presented densely arrayed spikes and elicited potent antibody responses in mice. Two immunizations with mRNA-LNP encoding spike-EABR elicited potent CD8+ T cell responses and superior neutralizing antibody responses against original and variant SARS-CoV-2 compared with conventional spike-encoding mRNA-LNP and purified spike-EABR eVLPs, improving neutralizing titers >10-fold against Omicron-based variants for 3 months post-boost. Thus, EABR technology enhances potency and breadth of vaccine-induced responses through antigen presentation on cell surfaces and eVLPs, enabling longer-lasting protection against SARS-CoV-2 and other viruses." @default.
- W4366606979 created "2023-04-23" @default.
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- W4366606979 date "2023-05-01" @default.
- W4366606979 modified "2023-09-27" @default.
- W4366606979 title "ESCRT recruitment to SARS-CoV-2 spike induces virus-like particles that improve mRNA vaccines" @default.
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- W4366606979 doi "https://doi.org/10.1016/j.cell.2023.04.024" @default.
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- W4366606979 hasPublicationYear "2023" @default.
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