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- W4366607312 abstract "Multistep automated pharmaceutical syntheses have been a long-term industrial goal. Automation not only enables the rapid and highly efficient preparation of organic compounds by eliminating the physical barriers, but also endow chemists with more time for critical thinking by relieving them from laborious work. With the growing demand for fast and efficient synthesis of active pharmaceutical ingredients (APIs) for drug development, several efforts have been made in various subfields to improve the universality and capability of automation in multistep synthesis. This review highlights the recent development of automated iterative synthesis, automated digitalized batch synthesis, automated solid-phase synthesis (SPS)-flow synthesis, automated radial synthesis, as well as automated multistep continuous-flow synthesis and how they complement each other in the automated synthesis of pharmaceuticals." @default.
- W4366607312 created "2023-04-23" @default.
- W4366607312 creator A5038927058 @default.
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- W4366607312 creator A5070016895 @default.
- W4366607312 creator A5084210456 @default.
- W4366607312 date "2023-06-01" @default.
- W4366607312 modified "2023-10-09" @default.
- W4366607312 title "Multistep automated synthesis of pharmaceuticals" @default.
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- W4366607312 doi "https://doi.org/10.1016/j.trechm.2023.03.008" @default.
- W4366607312 hasPublicationYear "2023" @default.
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