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- W4366607401 abstract "During husbandry, domestic animals are exposed to many factors that can influence their circadian physiology organization leading to an increase in animals’ discomfort. Thermal homeostasis is at the basis of animal wellness, the aim of the present study was to investigate the daily fluctuation of serum concentrations of 3,5,3’-triiodothyronine (T3) and thyroxine (T4) in association with the daily fluctuation of uncoupling protein 1 (UCP1) and clock gene Per2 in healthy horses housed in individual box, to improve the knowledge on this matter. Seven clinically healthy female Italian Saddle horses (8–10 years old, 510 ± 32 kg), were housed in individual boxes under natural photoperiod and environmental temperature and humidity. Blood samples were collected at 4-hour intervals over a 48-hour period, for the assessment of T3, T4, UCP1, and clock gene Per2. The application of two-way analysis of variance (ANOVA) on raw data showed a statistically significant effect of time of day on all studied parameters. A robust daily rhythm of T3, T4, and Per2 was observed. T3 showed a diurnal rhythm, with the acrophase at about 5 hours after sunrise, T4 acrophase was observed in the middle of the scotophase, Per2 acrophase was observed close to sunrise. In conclusion, we can claim that in horses kept under natural environmental conditions and not subjected to thermal stress, there is a daily rhythm of thyroid hormones associated with a daily rhythm of Per2 expression in the peripheral blood, and UCP1 remained constant during the two days." @default.
- W4366607401 created "2023-04-23" @default.
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- W4366607401 date "2023-07-01" @default.
- W4366607401 modified "2023-10-16" @default.
- W4366607401 title "Interplay Among the Daily Rhythm of the Thyroid Hormones, Uncoupling Protein 1 and the Clock Gene Per2 in Horses" @default.
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- W4366607401 doi "https://doi.org/10.1016/j.jevs.2023.104496" @default.
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