FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366607660> ?p ?o ?g. }

• W4366607660 abstract "Abstract Background: This study aimed to explore candidate genes involved in the pathogenesis of sinonasal inverted papilloma (SNIP) using bioinformatic analysis and experimental verification. Methods: For this, gene expression profiles (GSE193016) were downloaded from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were identified, with Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) being used to analyze the functions and pathways of DEGs. Co-expression networks were established using single-sample gene set enrichment analysis (GSEA). Furthermore, Search Tool for the Retrieval of Interacting Genes (STRING), Cytoscape, Molecular Complex Detection (MCODE), and Cytohubba were used to construct protein–protein interaction (PPI) networks, screen hub DEGs, and identify hub genes, with a miRNA-TF-hub gene regulatory network also being constructed. Finally, expression levels of identified hub genes were verified using RT-qPCR. Results: As a result, 985 DEGs were identified, including 343 upregulated and 642 downregulated genes. Functional enrichment analyses showed that upregulated DEGs were significantly enriched in epidermal development, cornification, keratinocyte differentiation, epidermal cell differentiation, and skin development. Meanwhile, downregulated DEGs were significantly enriched in muscle contraction, extracellular structure organization, muscle system process, extracellular matrix organization, and regulation of membrane potential. The top eight hub genes were MAD2L1, CDC20, CCNB2, CCNB1, AURKB, NDC80, KIF11, and DLGAP5 . During the validation stage, the expression of MAD2L1 was significantly higher in patients with SNIP than in those with normal nasal mucosa. Conclusions: Overall, this study identified key genes associated with SNIP and their biological functions. Furthermore, a variety of predicted genes involved in the cell cycle were found to be connected to SNIP pathogenesis and malignant transformation. MAD2L1 may play an important role in SNIP pathogenesis, providing novel insights into the occurrence and development of SNIP." @default.
• W4366607660 created "2023-04-23" @default.
• W4366607660 creator A5039931673 @default.
• W4366607660 creator A5045067652 @default.
• W4366607660 creator A5086283251 @default.
• W4366607660 date "2023-04-21" @default.
• W4366607660 modified "2023-09-24" @default.
• W4366607660 title "Identification and Potential Value of Candidate Genes in Patients with Sinonasal inverted papilloma" @default.
• W4366607660 cites W1511613542 @default.
• W4366607660 cites W2035618305 @default.
• W4366607660 cites W2076161831 @default.
• W4366607660 cites W2094678200 @default.
• W4366607660 cites W2100239923 @default.
• W4366607660 cites W2103912979 @default.
• W4366607660 cites W2130410032 @default.
• W4366607660 cites W2146512944 @default.
• W4366607660 cites W2158217645 @default.
• W4366607660 cites W2159675211 @default.
• W4366607660 cites W2323080934 @default.
• W4366607660 cites W2406250479 @default.
• W4366607660 cites W2614713266 @default.
• W4366607660 cites W2810245110 @default.
• W4366607660 cites W2900569176 @default.
• W4366607660 cites W2975259267 @default.
• W4366607660 cites W2991524512 @default.
• W4366607660 cites W3007286214 @default.
• W4366607660 cites W3029717128 @default.
• W4366607660 cites W3091944805 @default.
• W4366607660 cites W3197342850 @default.
• W4366607660 cites W3206352331 @default.
• W4366607660 cites W4220737377 @default.
• W4366607660 cites W4223433044 @default.
• W4366607660 cites W4280510488 @default.
• W4366607660 cites W4293211768 @default.
• W4366607660 cites W62433807 @default.
• W4366607660 doi "https://doi.org/10.21203/rs.3.rs-2807689/v1" @default.
• W4366607660 hasPublicationYear "2023" @default.
• W4366607660 type Work @default.
• W4366607660 citedByCount "0" @default.
• W4366607660 crossrefType "posted-content" @default.
• W4366607660 hasAuthorship W4366607660A5039931673 @default.
• W4366607660 hasAuthorship W4366607660A5045067652 @default.
• W4366607660 hasAuthorship W4366607660A5086283251 @default.
• W4366607660 hasBestOaLocation W43666076601 @default.
• W4366607660 hasConcept C104317684 @default.
• W4366607660 hasConcept C127561419 @default.
• W4366607660 hasConcept C150194340 @default.
• W4366607660 hasConcept C152724338 @default.
• W4366607660 hasConcept C162317418 @default.
• W4366607660 hasConcept C18431079 @default.
• W4366607660 hasConcept C54355233 @default.
• W4366607660 hasConcept C69991583 @default.
• W4366607660 hasConcept C70721500 @default.
• W4366607660 hasConcept C86803240 @default.
• W4366607660 hasConceptScore W4366607660C104317684 @default.
• W4366607660 hasConceptScore W4366607660C127561419 @default.
• W4366607660 hasConceptScore W4366607660C150194340 @default.
• W4366607660 hasConceptScore W4366607660C152724338 @default.
• W4366607660 hasConceptScore W4366607660C162317418 @default.
• W4366607660 hasConceptScore W4366607660C18431079 @default.
• W4366607660 hasConceptScore W4366607660C54355233 @default.
• W4366607660 hasConceptScore W4366607660C69991583 @default.
• W4366607660 hasConceptScore W4366607660C70721500 @default.
• W4366607660 hasConceptScore W4366607660C86803240 @default.
• W4366607660 hasLocation W43666076601 @default.
• W4366607660 hasOpenAccess W4366607660 @default.
• W4366607660 hasPrimaryLocation W43666076601 @default.
• W4366607660 hasRelatedWork W1556453709 @default.
• W4366607660 hasRelatedWork W2021523535 @default.
• W4366607660 hasRelatedWork W2371696992 @default.
• W4366607660 hasRelatedWork W2509567726 @default.
• W4366607660 hasRelatedWork W2563598809 @default.
• W4366607660 hasRelatedWork W2782502720 @default.
• W4366607660 hasRelatedWork W2897281778 @default.
• W4366607660 hasRelatedWork W3153252782 @default.
• W4366607660 hasRelatedWork W4224439911 @default.
• W4366607660 hasRelatedWork W4316464720 @default.
• W4366607660 isParatext "false" @default.
• W4366607660 isRetracted "false" @default.
• W4366607660 workType "article" @default.