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- W4366608294 abstract "This article describes the use of prognostic, predictive, and response biomarkers that have been developed for autosomal dominant polycystic kidney disease and their use in clinical care or drug development. We focus on biochemical markers that can be assayed in patients' blood and urine and their association with the outcome of decreased glomerular filtration rate. There have been several studies on prognostic biomarkers. The most promising ones have been markers of tubular injury, inflammation, metabolism, or the vasopressin-urinary concentration axis. So far, none have been shown to be superior to kidney volume-based biomarkers. Several biomarkers are additive to kidney volume and genotype in prognostic models, but there have been few direct comparisons between the biochemical markers to identify the best ones. Moreover, there is a lack of uniformity in the statistical tools used to assess and compare biomarkers. There have been few reports of predictive and response biomarkers, and none are suitable surrogate endpoints. The U.S. Food and Drug Administration's Biomarker Qualification Program provides a regulatory pathway to approve biomarkers for use across multiple drug-development programs." @default.
- W4366608294 created "2023-04-23" @default.
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- W4366608294 date "2023-05-01" @default.
- W4366608294 modified "2023-10-12" @default.
- W4366608294 title "Biomarkers in Polycystic Kidney Disease: Are We There?" @default.
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- W4366608294 doi "https://doi.org/10.1053/j.akdh.2022.12.009" @default.
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