FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366608520> ?p ?o ?g. }

• W4366608520 endingPage "284" @default.
• W4366608520 startingPage "261" @default.
• W4366608520 abstract "Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary disorder characterized by relentless growth of innumerable renal cysts bilaterally, associated with decline in glomerular filtration rate over the course of decades. The burden of ADPKD and its treatment is associated with a significant economic and societal cost. Despite several clinical studies conducted over the past decade, only one treatment has been approved by regulatory agencies to slow disease progression in ADPKD. Elucidating feasible endpoints and clear regulatory pathway may stimulate interest in developing and translating novel therapeutics. This review summarizes the recent progress, challenges, and opportunities in drug development for ADPKD. We discuss the traditional and accelerated regulatory approval pathways, the various clinical trials endpoints, and biomarkers in ADPKD. Furthermore, we propose strategies that could optimize the clinical trial design in ADPKD. Finally, we owe it to our ADPKD patient community to strive for international collaborative studies geared toward discovery and validation of surrogate endpoints and to rally for funded infrastructure that would allow phase 3 master protocols in ADPKD. These advances will serve to derisk and potentially accelerate the development of therapies and eventually bring hope to patients and families who endure through this devastating disease." @default.
• W4366608520 created "2023-04-23" @default.
• W4366608520 creator A5025388066 @default.
• W4366608520 creator A5085269683 @default.
• W4366608520 date "2023-05-01" @default.
• W4366608520 modified "2023-10-07" @default.
• W4366608520 title "Drug Development in Autosomal Dominant Polycystic Kidney Disease: Opportunities and Challenges" @default.
• W4366608520 cites W1965644948 @default.
• W4366608520 cites W1997286719 @default.
• W4366608520 cites W2022403877 @default.
• W4366608520 cites W2036937508 @default.
• W4366608520 cites W2053094829 @default.
• W4366608520 cites W2082060108 @default.
• W4366608520 cites W2086570276 @default.
• W4366608520 cites W2099652907 @default.
• W4366608520 cites W2101067234 @default.
• W4366608520 cites W2107153099 @default.
• W4366608520 cites W2107867025 @default.
• W4366608520 cites W2112643254 @default.
• W4366608520 cites W2116811919 @default.
• W4366608520 cites W2120488567 @default.
• W4366608520 cites W2129253605 @default.
• W4366608520 cites W2146668712 @default.
• W4366608520 cites W2172223249 @default.
• W4366608520 cites W2203078370 @default.
• W4366608520 cites W2276596278 @default.
• W4366608520 cites W2281065280 @default.
• W4366608520 cites W2321986725 @default.
• W4366608520 cites W2331546748 @default.
• W4366608520 cites W2521524560 @default.
• W4366608520 cites W2577378324 @default.
• W4366608520 cites W2586388923 @default.
• W4366608520 cites W2590005725 @default.
• W4366608520 cites W2604498722 @default.
• W4366608520 cites W2739027038 @default.
• W4366608520 cites W2739037882 @default.
• W4366608520 cites W2746704802 @default.
• W4366608520 cites W2765795120 @default.
• W4366608520 cites W2898525585 @default.
• W4366608520 cites W2905115006 @default.
• W4366608520 cites W2906737259 @default.
• W4366608520 cites W2919249442 @default.
• W4366608520 cites W2922441540 @default.
• W4366608520 cites W2930463134 @default.
• W4366608520 cites W3006965099 @default.
• W4366608520 cites W3012813218 @default.
• W4366608520 cites W3035106699 @default.
• W4366608520 cites W3040659673 @default.
• W4366608520 cites W3118211008 @default.
• W4366608520 cites W3122507953 @default.
• W4366608520 cites W3123898773 @default.
• W4366608520 cites W3135355396 @default.
• W4366608520 cites W3148049993 @default.
• W4366608520 cites W3152017609 @default.
• W4366608520 cites W3176251154 @default.
• W4366608520 cites W3192198801 @default.
• W4366608520 cites W4236168361 @default.
• W4366608520 cites W4281398364 @default.
• W4366608520 cites W4292850078 @default.
• W4366608520 cites W4293728899 @default.
• W4366608520 doi "https://doi.org/10.1053/j.akdh.2023.01.004" @default.
• W4366608520 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37088528" @default.
• W4366608520 hasPublicationYear "2023" @default.
• W4366608520 type Work @default.
• W4366608520 citedByCount "0" @default.
• W4366608520 crossrefType "journal-article" @default.
• W4366608520 hasAuthorship W4366608520A5025388066 @default.
• W4366608520 hasAuthorship W4366608520A5085269683 @default.
• W4366608520 hasBestOaLocation W43666085201 @default.
• W4366608520 hasConcept C126322002 @default.
• W4366608520 hasConcept C177713679 @default.
• W4366608520 hasConcept C2776266639 @default.
• W4366608520 hasConcept C2779134260 @default.
• W4366608520 hasConcept C2780035454 @default.
• W4366608520 hasConcept C2780145431 @default.
• W4366608520 hasConcept C535046627 @default.
• W4366608520 hasConcept C60644358 @default.
• W4366608520 hasConcept C64903051 @default.
• W4366608520 hasConcept C71924100 @default.
• W4366608520 hasConcept C86803240 @default.
• W4366608520 hasConcept C98274493 @default.
• W4366608520 hasConceptScore W4366608520C126322002 @default.
• W4366608520 hasConceptScore W4366608520C177713679 @default.
• W4366608520 hasConceptScore W4366608520C2776266639 @default.
• W4366608520 hasConceptScore W4366608520C2779134260 @default.
• W4366608520 hasConceptScore W4366608520C2780035454 @default.
• W4366608520 hasConceptScore W4366608520C2780145431 @default.
• W4366608520 hasConceptScore W4366608520C535046627 @default.
• W4366608520 hasConceptScore W4366608520C60644358 @default.
• W4366608520 hasConceptScore W4366608520C64903051 @default.
• W4366608520 hasConceptScore W4366608520C71924100 @default.
• W4366608520 hasConceptScore W4366608520C86803240 @default.
• W4366608520 hasConceptScore W4366608520C98274493 @default.
• W4366608520 hasIssue "3" @default.
• W4366608520 hasLocation W43666085201 @default.
• W4366608520 hasLocation W43666085202 @default.
• W4366608520 hasOpenAccess W4366608520 @default.
• W4366608520 hasPrimaryLocation W43666085201 @default.

• next