Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366680147> ?p ?o ?g. }
- W4366680147 endingPage "812" @default.
- W4366680147 startingPage "812" @default.
- W4366680147 abstract "Pituitary neuroendocrine tumors (PitNETs), the third most common intracranial tumor, are mostly benign. However, some of them may display a more aggressive behavior, invading into the surrounding structures. While they may rarely metastasize, they may resist different treatment modalities. Several major advances in molecular biology in the past few years led to the discovery of the possible mechanisms involved in pituitary tumorigenesis with a possible therapeutic implication. The mutations in the different proteins involved in the Gsa/protein kinase A/c AMP signaling pathway are well-known and are responsible for many PitNETS, such as somatotropinomas and, in the context of syndromes, as the McCune–Albright syndrome, Carney complex, familiar isolated pituitary adenoma (FIPA), and X-linked acrogigantism (XLAG). The other pathways involved are the MAPK/ERK, PI3K/Akt, Wnt, and the most recently studied HIPPO pathways. Moreover, the mutations in several other tumor suppressor genes, such as menin and CDKN1B, are responsible for the MEN1 and MEN4 syndromes and succinate dehydrogenase (SDHx) in the context of the 3PAs syndrome. Furthermore, the pituitary stem cells and miRNAs hold an essential role in pituitary tumorigenesis and may represent new molecular targets for their diagnosis and treatment. This review aims to summarize the different cell signaling pathways and genes involved in pituitary tumorigenesis in an attempt to clarify their implications for diagnosis and management." @default.
- W4366680147 created "2023-04-24" @default.
- W4366680147 creator A5008173320 @default.
- W4366680147 creator A5010755835 @default.
- W4366680147 creator A5033732324 @default.
- W4366680147 creator A5038356661 @default.
- W4366680147 date "2023-04-21" @default.
- W4366680147 modified "2023-10-01" @default.
- W4366680147 title "Pituitary Tumorigenesis—Implications for Management" @default.
- W4366680147 cites W1124473360 @default.
- W4366680147 cites W1531523780 @default.
- W4366680147 cites W1543035538 @default.
- W4366680147 cites W1545743138 @default.
- W4366680147 cites W1561133359 @default.
- W4366680147 cites W1601683999 @default.
- W4366680147 cites W1603274157 @default.
- W4366680147 cites W1606957740 @default.
- W4366680147 cites W1607070363 @default.
- W4366680147 cites W1821188906 @default.
- W4366680147 cites W1840055728 @default.
- W4366680147 cites W1897633092 @default.
- W4366680147 cites W1925935443 @default.
- W4366680147 cites W1964210333 @default.
- W4366680147 cites W1966955143 @default.
- W4366680147 cites W1967768414 @default.
- W4366680147 cites W1969692642 @default.
- W4366680147 cites W1972611676 @default.
- W4366680147 cites W1973255852 @default.
- W4366680147 cites W1973399318 @default.
- W4366680147 cites W1974366727 @default.
- W4366680147 cites W1974510931 @default.
- W4366680147 cites W1975715657 @default.
- W4366680147 cites W1976002503 @default.
- W4366680147 cites W1976378332 @default.
- W4366680147 cites W1979683683 @default.
- W4366680147 cites W1981695027 @default.
- W4366680147 cites W1981739548 @default.
- W4366680147 cites W1987476099 @default.
- W4366680147 cites W1988395319 @default.
- W4366680147 cites W1989504643 @default.
- W4366680147 cites W1990739246 @default.
- W4366680147 cites W1991275732 @default.
- W4366680147 cites W1992664787 @default.
- W4366680147 cites W1993095991 @default.
- W4366680147 cites W1998095188 @default.
- W4366680147 cites W1998203489 @default.
- W4366680147 cites W2000253969 @default.
- W4366680147 cites W2000715464 @default.
- W4366680147 cites W2003164061 @default.
- W4366680147 cites W2005483494 @default.
- W4366680147 cites W2007916618 @default.
- W4366680147 cites W2008354592 @default.
- W4366680147 cites W2010375889 @default.
- W4366680147 cites W2011796667 @default.
- W4366680147 cites W2013935331 @default.
- W4366680147 cites W2014049239 @default.
- W4366680147 cites W2014078365 @default.
- W4366680147 cites W2014096417 @default.
- W4366680147 cites W2015321769 @default.
- W4366680147 cites W2020893494 @default.
- W4366680147 cites W2021976734 @default.
- W4366680147 cites W2023194188 @default.
- W4366680147 cites W2023334774 @default.
- W4366680147 cites W2023443384 @default.
- W4366680147 cites W2024109575 @default.
- W4366680147 cites W2025570007 @default.
- W4366680147 cites W2026098321 @default.
- W4366680147 cites W2026569756 @default.
- W4366680147 cites W2027150010 @default.
- W4366680147 cites W2027562431 @default.
- W4366680147 cites W2030150930 @default.
- W4366680147 cites W2030170263 @default.
- W4366680147 cites W2032940569 @default.
- W4366680147 cites W2035500336 @default.
- W4366680147 cites W2037486292 @default.
- W4366680147 cites W2039094079 @default.
- W4366680147 cites W2041430419 @default.
- W4366680147 cites W2042481999 @default.
- W4366680147 cites W2048163316 @default.
- W4366680147 cites W2049832435 @default.
- W4366680147 cites W2050070509 @default.
- W4366680147 cites W2052101095 @default.
- W4366680147 cites W2054026360 @default.
- W4366680147 cites W2055382218 @default.
- W4366680147 cites W2058347587 @default.
- W4366680147 cites W2058890667 @default.
- W4366680147 cites W2059027605 @default.
- W4366680147 cites W2061106767 @default.
- W4366680147 cites W2062289724 @default.
- W4366680147 cites W2062805157 @default.
- W4366680147 cites W2062826804 @default.
- W4366680147 cites W2063821942 @default.
- W4366680147 cites W2064533401 @default.
- W4366680147 cites W2065397528 @default.
- W4366680147 cites W2066636886 @default.
- W4366680147 cites W2066833478 @default.
- W4366680147 cites W2066919884 @default.
- W4366680147 cites W2067378598 @default.