Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366688194> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W4366688194 endingPage "625" @default.
- W4366688194 startingPage "625" @default.
- W4366688194 abstract "Neuroangiostrongyliasis (NAS) is an emerging tropical disease in humans and some animals which is caused by infection with the parasitic nematode Angiostrongylus cantonensis. It is the leading cause of eosinophilic meningitis worldwide. Diagnoses in humans and susceptible animals are generally presumptive and easily confused with other central nervous system disorders. The 31 kDa antigen is currently the only NAS immunodiagnostic assay that has achieved 100% sensitivity. However, little is known about the humoral immune response against the 31 kDa antigen in NAS infections, which would be critical for widespread adoption of this assay. We used the Hawai’i 31 kDa isolate in an indirect ELISA assay to confirm the presence of immunoglobulin IgG, IgM, IgA, and IgE isotypes in six-week post-infection plasma from lab-reared rats infected with 50 live, third-stage, A. cantonensis larvae isolated from a wild Parmarion martensi semi-slug. Our results confirmed the presence of all four isotypes against the Hawaii 31 kDa isolate, with sensitivity ranging from 22–100%. The IgG isotype showed 100% sensitivity in detecting A. cantonensis infection, which validates the use of IgG indirect ELISA with 31 kDa antigen as an effective immunodiagnostic assay for rats six weeks post-infection. Given each isotype may be present at different times during NAS infections, our data provides preliminary information on the humoral immune response to A. cantonensis infection in lab-reared rats and serves as a baseline for future studies." @default.
- W4366688194 created "2023-04-24" @default.
- W4366688194 creator A5007573205 @default.
- W4366688194 creator A5021079769 @default.
- W4366688194 creator A5028745752 @default.
- W4366688194 creator A5055155068 @default.
- W4366688194 date "2023-04-21" @default.
- W4366688194 modified "2023-09-25" @default.
- W4366688194 title "Comparison of Antibody Isotype Response to Angiostrongylus cantonensis in Experimentally Infected Rats (Rattus norvegicus) Using Hawai’i 31 kDa Antigen in an Indirect ELISA" @default.
- W4366688194 cites W1467666301 @default.
- W4366688194 cites W1692108117 @default.
- W4366688194 cites W2019479005 @default.
- W4366688194 cites W2041014908 @default.
- W4366688194 cites W2054993795 @default.
- W4366688194 cites W2070507740 @default.
- W4366688194 cites W2092372865 @default.
- W4366688194 cites W2149097451 @default.
- W4366688194 cites W2153003449 @default.
- W4366688194 cites W2168420558 @default.
- W4366688194 cites W2184532222 @default.
- W4366688194 cites W2186334990 @default.
- W4366688194 cites W2313696385 @default.
- W4366688194 cites W2346147352 @default.
- W4366688194 cites W2403425115 @default.
- W4366688194 cites W2412713911 @default.
- W4366688194 cites W2555460222 @default.
- W4366688194 cites W275301109 @default.
- W4366688194 cites W2772895063 @default.
- W4366688194 cites W2887335676 @default.
- W4366688194 cites W2956013058 @default.
- W4366688194 cites W2961167085 @default.
- W4366688194 cites W2990824863 @default.
- W4366688194 cites W3046645418 @default.
- W4366688194 cites W3110637610 @default.
- W4366688194 doi "https://doi.org/10.3390/pathogens12040625" @default.
- W4366688194 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37111511" @default.
- W4366688194 hasPublicationYear "2023" @default.
- W4366688194 type Work @default.
- W4366688194 citedByCount "0" @default.
- W4366688194 crossrefType "journal-article" @default.
- W4366688194 hasAuthorship W4366688194A5007573205 @default.
- W4366688194 hasAuthorship W4366688194A5021079769 @default.
- W4366688194 hasAuthorship W4366688194A5028745752 @default.
- W4366688194 hasAuthorship W4366688194A5055155068 @default.
- W4366688194 hasBestOaLocation W43666881941 @default.
- W4366688194 hasConcept C141105273 @default.
- W4366688194 hasConcept C147483822 @default.
- W4366688194 hasConcept C159047783 @default.
- W4366688194 hasConcept C159654299 @default.
- W4366688194 hasConcept C165901193 @default.
- W4366688194 hasConcept C203014093 @default.
- W4366688194 hasConcept C2776349312 @default.
- W4366688194 hasConcept C2777991845 @default.
- W4366688194 hasConcept C2780898057 @default.
- W4366688194 hasConcept C542903549 @default.
- W4366688194 hasConcept C86803240 @default.
- W4366688194 hasConcept C8891405 @default.
- W4366688194 hasConcept C89423630 @default.
- W4366688194 hasConceptScore W4366688194C141105273 @default.
- W4366688194 hasConceptScore W4366688194C147483822 @default.
- W4366688194 hasConceptScore W4366688194C159047783 @default.
- W4366688194 hasConceptScore W4366688194C159654299 @default.
- W4366688194 hasConceptScore W4366688194C165901193 @default.
- W4366688194 hasConceptScore W4366688194C203014093 @default.
- W4366688194 hasConceptScore W4366688194C2776349312 @default.
- W4366688194 hasConceptScore W4366688194C2777991845 @default.
- W4366688194 hasConceptScore W4366688194C2780898057 @default.
- W4366688194 hasConceptScore W4366688194C542903549 @default.
- W4366688194 hasConceptScore W4366688194C86803240 @default.
- W4366688194 hasConceptScore W4366688194C8891405 @default.
- W4366688194 hasConceptScore W4366688194C89423630 @default.
- W4366688194 hasIssue "4" @default.
- W4366688194 hasLocation W43666881941 @default.
- W4366688194 hasLocation W43666881942 @default.
- W4366688194 hasLocation W43666881943 @default.
- W4366688194 hasOpenAccess W4366688194 @default.
- W4366688194 hasPrimaryLocation W43666881941 @default.
- W4366688194 hasRelatedWork W1484759019 @default.
- W4366688194 hasRelatedWork W1546868941 @default.
- W4366688194 hasRelatedWork W1974049689 @default.
- W4366688194 hasRelatedWork W2072492485 @default.
- W4366688194 hasRelatedWork W2087982072 @default.
- W4366688194 hasRelatedWork W2091507184 @default.
- W4366688194 hasRelatedWork W2099244599 @default.
- W4366688194 hasRelatedWork W2102440256 @default.
- W4366688194 hasRelatedWork W2152708820 @default.
- W4366688194 hasRelatedWork W2220102944 @default.
- W4366688194 hasVolume "12" @default.
- W4366688194 isParatext "false" @default.
- W4366688194 isRetracted "false" @default.
- W4366688194 workType "article" @default.