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- W4366705091 abstract "An isoniazid N-acetylation phenotyping study was carried out in 200 human volunteers. A single urine sample taken 5 h post-isoniazid oral dose of 300 mg was analyzed and urinary concentrations of isoniazid and its metabolite acetylisoniazid were determined by high-performance liquid chromatography. Acetylator phenotype was determined from the metabolic ratio of N-acetylisoniazid to isoniazid concentration in the urine sample. The cut-off value, antimode, to distinguish between slow and fast acetylators was determined by probit analysis. Of the total 194 subjects phenotyped, 70.1 % were slow acetylators, 27.6 % were intermediate acetylators and 2.7 % were fast acetylators." @default.
- W4366705091 created "2023-04-24" @default.
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- W4366705091 date "2022-01-01" @default.
- W4366705091 modified "2023-10-18" @default.
- W4366705091 title "Determination of the Isoniazid N-Acetylation Phenotype in a Sample Indian Population" @default.
- W4366705091 doi "https://doi.org/10.36468/pharmaceutical-sciences.1096" @default.
- W4366705091 hasPublicationYear "2022" @default.
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